{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T02:40:33Z","timestamp":1776134433796,"version":"3.50.1"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejog.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Obstetrics &amp; Gynecology and Reproductive Biology"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.ejogrb.2023.10.011","type":"journal-article","created":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T21:48:23Z","timestamp":1697060903000},"page":"112-119","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Vaginal probiotics as an adjunct to antibiotic prophylaxis in the management of preterm premature rupture of membranes: A systematic review and meta-analysis of randomized controlled trials"],"prefix":"10.1016","volume":"291","author":[{"given":"Saeed","family":"Baradwan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rayan","family":"AlSghan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hussein","family":"Sabban","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khalid","family":"Khadawardi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zainab","family":"Abdelrahman Mohamed Ali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lujain Hisham A.","family":"Felemban","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samir","family":"Khamis Galal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdelrahman","family":"Ragab Rashed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamer","family":"Salah Elsayed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elsayed","family":"Mohammed Ibrahim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdelmonsef","family":"Abdelghaffar Moustafa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed","family":"Mohamed Abdelhakim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed","family":"Abdelaziz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hagar","family":"Abdelgawad Magdy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed E.","family":"ElHodiby","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejogrb.2023.10.011_b0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejogrb.2019.02.021","article-title":"Preterm premature rupture of the membranes: Guidelines for clinical practice from the French College of Gynaecologists and Obstetricians (CNGOF)","volume":"236","author":"Schmitz","year":"2019","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.ejogrb.2023.10.011_b0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejogrb.2022.04.027","article-title":"Hemodynamic assessment in patients with preterm premature rupture of the membranes (pPROM)","volume":"274","author":"Valensise","year":"2022","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.ejogrb.2023.10.011_b0015","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1097\/00006254-199308000-00026","article-title":"Preterm premature rupture of membranes","volume":"48","author":"Maxwell","year":"1993","journal-title":"Obstet Gynecol Surv"},{"key":"10.1016\/j.ejogrb.2023.10.011_b0020","first-page":"316","article-title":"Amniocentesis for gram stain and culture in preterm premature rupture of the membranes","volume":"66","author":"Broekhuizen","year":"1985","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ejogrb.2023.10.011_b0025","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1055\/s-2004-828609","article-title":"Contemporary management of preterm premature rupture of membranes: determinants of latency and neonatal outcome","volume":"21","author":"Gopalani","year":"2004","journal-title":"Am J Perinatol"},{"key":"10.1016\/j.ejogrb.2023.10.011_b0030","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.jogoh.2018.12.007","article-title":"Enterobacteria vaginal colonization among patients with preterm premature rupture of membranes from 24 to 34 weeks of gestation and neonatal infection risk","volume":"48","author":"Merello","year":"2019","journal-title":"J Gynecol Obstet Hum Reprod"},{"key":"10.1016\/j.ejogrb.2023.10.011_b0035","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/j.1440-1754.1997.tb01014.x","article-title":"Perinatal outcome following conservative management of mid-trimester pre-labour rupture of the membranes","volume":"33","author":"Nourse","year":"1997","journal-title":"J Paediatr Child Health"},{"key":"10.1016\/j.ejogrb.2023.10.011_b0040","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.ogc.2005.03.003","article-title":"Preterm premature rupture of the membranes: current approaches to evaluation and management","volume":"32","author":"Mercer","year":"2005","journal-title":"Obstet Gynecol Clin N Am"},{"key":"10.1016\/j.ejogrb.2023.10.011_b0045","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1007\/s00404-009-1318-3","article-title":"Vaginal microbial flora and outcome of pregnancy","volume":"281","author":"Donati","year":"2010","journal-title":"Arch Gynecol Obstet"},{"key":"10.1016\/j.ejogrb.2023.10.011_b0050","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/S0140-6736(03)12489-0","article-title":"Gut flora in health and disease","volume":"361","author":"Guarner","year":"2003","journal-title":"Lancet Lond Engl"},{"key":"10.1016\/j.ejogrb.2023.10.011_b0055","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1186\/1471-2180-12-236","article-title":"Dietary supplementation with probiotics during late pregnancy: outcome on vaginal microbiota and cytokine secretion","volume":"12","author":"Vitali","year":"2012","journal-title":"BMC Microbiol"},{"key":"10.1016\/j.ejogrb.2023.10.011_b0060","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.ejogrb.2022.03.008","article-title":"Probiotics Properties: A Focus on Pregnancy Outcomes","volume":"272","author":"Seif El Dahan","year":"2022","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.ejogrb.2023.10.011_b0065","first-page":"CD005941","article-title":"Probiotics for preventing preterm labour","volume":"2007","author":"Othman","year":"2007","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.ejogrb.2023.10.011_b0070","first-page":"772","article-title":"Probiotics in pregnancy and maternal outcomes: a systematic review","volume":"26","author":"Lindsay","year":"2013","journal-title":"J Matern-Fetal Neonatal Med Off J Eur Assoc Perinat Med Fed Asia Ocean Perinat Soc Int Soc Perinat Obstet"},{"key":"10.1016\/j.ejogrb.2023.10.011_b0075","first-page":"59","article-title":"The Effects of Vaginal Probiotic Administration on Perinatal Outcomes in Patients with Premature Preterm Rupture of Membrane","volume":"3","author":"Kahvazi","year":"2022","journal-title":"Arch Obstet Gynaecol"},{"key":"10.1016\/j.ejogrb.2023.10.011_b0080","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1080\/01443615.2021.1993803","article-title":"Vaginal probiotics as an adjunct to antibiotic prophylaxis in the management of preterm premature rupture of the membranes","volume":"42","author":"Yadav","year":"2022","journal-title":"J Obstet Gynaecol"},{"key":"10.1016\/j.ejogrb.2023.10.011_b0085","doi-asserted-by":"crossref","first-page":"264","DOI":"10.7326\/0003-4819-151-4-200908180-00135","article-title":"Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement","volume":"151","author":"Moher","year":"2009","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.ejogrb.2023.10.011_b0090","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.d5928","article-title":"The Cochrane Collaboration\u2019s tool for assessing risk of bias in randomised trials","volume":"343","author":"Higgins","year":"2011","journal-title":"BMJ"},{"key":"10.1016\/j.ejogrb.2023.10.011_b0095","first-page":"557","volume":"327","author":"Julian","year":"2003","journal-title":"Measuring inconsistency in meta-analyses Rapid responses Topic collections"},{"key":"10.1016\/j.ejogrb.2023.10.011_b0100","first-page":"1","article-title":"Bias in meta \u00ad analysis detected by a simple, graphical test","volume":"14","author":"Egger","year":"2015","journal-title":"BMJ"},{"key":"10.1016\/j.ejogrb.2023.10.011_b0105","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1002\/sim.1461","article-title":"Adjusting for publication bias in the presence of heterogeneity","volume":"22","author":"Terrin","year":"2003","journal-title":"Stat Med Stat Med"},{"key":"10.1016\/j.ejogrb.2023.10.011_b0110","doi-asserted-by":"crossref","first-page":"7672","DOI":"10.21608\/ejhm.2018.19899","article-title":"Vaginal Probiotic Administration in The Management of Preterm Premature Rupture of Membranes","volume":"73","author":"Ibrahim","year":"2018","journal-title":"Egypt J Hosp Med"},{"key":"10.1016\/j.ejogrb.2023.10.011_b0115","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1159\/000450995","article-title":"Vaginal Probiotic Administration in the Management of Preterm Premature Rupture of Membranes","volume":"42","author":"Daskalakis","year":"2017","journal-title":"Fetal Diagn Ther"},{"key":"10.1016\/j.ejogrb.2023.10.011_b0120","doi-asserted-by":"crossref","unstructured":"Kavak SB, Kavak E, Ilhan R, Atilgan R, Arat O, Deveci U, et al. The efficacy of ampicillin and Lactobacillus casei rhamnosus in the active management of preterm premature rupture of membranes remote from term. Drug Des Devel Ther 2014:1169.","DOI":"10.2147\/DDDT.S68552"},{"key":"10.1016\/j.ejogrb.2023.10.011_b0125","first-page":"15","article-title":"Lactobacillus Rhamnosus BMX 54 Vaginal Application Usefulness as Adjuvant Therapy for Preterm Premature Rupture of Membranes (PPROM) in the Second Trimester of Pregnancy","volume":"2","author":"Luzi","year":"2018","journal-title":"Int J Pediatr Neonatal Health"},{"key":"10.1016\/j.ejogrb.2023.10.011_b0130","doi-asserted-by":"crossref","first-page":"3527","DOI":"10.1080\/01443615.2022.2151349","article-title":"Vaginal probiotics on the outcomes of premature rupture of membranes: a pilot randomised clinical trial","volume":"42","author":"de Moraes","year":"2022","journal-title":"J Obstet Gynaecol"},{"key":"10.1016\/j.ejogrb.2023.10.011_b0135","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1016\/S0029-7844(96)00339-0","article-title":"Serum C-reactive protein, white blood cell count, and amniotic fluid white blood cell count in women with preterm premature rupture of membranes","volume":"88","author":"Yoon","year":"1996","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ejogrb.2023.10.011_b0140","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/S0301-2115(03)00084-8","article-title":"Serum highly sensitive C-reactive protein in preterm premature rupture of membranes","volume":"110","author":"Loukovaara","year":"2003","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.ejogrb.2023.10.011_b0145","doi-asserted-by":"crossref","first-page":"e80074","DOI":"10.1371\/journal.pone.0080074","article-title":"Vaginal pH and microbicidal lactic acid when lactobacilli dominate the microbiota","volume":"8","author":"O\u2019Hanlon","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.ejogrb.2023.10.011_b0150","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s00404-012-2293-7","article-title":"Normal vaginal flora, disorders and application of probiotics in pregnancy","volume":"286","author":"Stojanovi\u0107","year":"2012","journal-title":"Arch Gynecol Obstet"},{"key":"10.1016\/j.ejogrb.2023.10.011_b0155","doi-asserted-by":"crossref","first-page":"423","DOI":"10.3920\/BM2014.0088","article-title":"The effect of probiotics on serum levels of cytokine and endotoxin in peritoneal dialysis patients: a randomised, double-blind, placebo-controlled trial","volume":"6","author":"Wang","year":"2015","journal-title":"Benef Microbes"},{"key":"10.1016\/j.ejogrb.2023.10.011_b0160","first-page":"434","article-title":"Probiotics - a helpful additional therapy for bacterial vaginosis","volume":"6","author":"Bodean","year":"2013","journal-title":"J Med Life"}],"container-title":["European Journal of Obstetrics &amp; Gynecology and Reproductive Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211523007625?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211523007625?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T06:02:22Z","timestamp":1759557742000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301211523007625"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":32,"alternative-id":["S0301211523007625"],"URL":"https:\/\/doi.org\/10.1016\/j.ejogrb.2023.10.011","relation":{},"ISSN":["0301-2115"],"issn-type":[{"value":"0301-2115","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Vaginal probiotics as an adjunct to antibiotic prophylaxis in the management of preterm premature rupture of membranes: A systematic review and meta-analysis of randomized controlled trials","name":"articletitle","label":"Article Title"},{"value":"European Journal of Obstetrics & Gynecology and Reproductive Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejogrb.2023.10.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}