{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T03:54:03Z","timestamp":1775620443264,"version":"3.50.1"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejog.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Obstetrics & Gynecology and Reproductive Biology"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.ejogrb.2024.03.015","type":"journal-article","created":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T04:35:57Z","timestamp":1710822957000},"page":"86-90","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Human epididymis protein 4: Analysis of national health and nutrition examination survey data"],"prefix":"10.1016","volume":"297","author":[{"given":"Emily R.","family":"Penick","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8971-1201","authenticated-orcid":false,"given":"Thomas A.","family":"Beltran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y. Sammy","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen L.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.ejogrb.2024.03.015_b0005","doi-asserted-by":"crossref","first-page":"896","DOI":"10.6004\/jnccn.2019.0039","article-title":"NCCN guidelines insights: Ovarian cancer, version 1.2019","volume":"17","author":"Armstrong","year":"2019","journal-title":"J Natl Compr Canc Netw"},{"issue":"1","key":"10.1016\/j.ejogrb.2024.03.015_b0010","first-page":"7","article-title":"Cancer statistics, 2020","volume":"70","author":"Siegel","year":"2020","journal-title":"CA Cancer J Clin"},{"issue":"6","key":"10.1016\/j.ejogrb.2024.03.015_b0015","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1001\/jama.2017.21421","article-title":"Screening for Ovarian cancer: updated evidence report and systematic review for the US preventive services task force","volume":"319","author":"Henderson","year":"2018","journal-title":"JAMA"},{"issue":"5","key":"10.1016\/j.ejogrb.2024.03.015_b0020","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1172\/JCI110380","article-title":"Reactivity of a monoclonal antibody with human ovarian carcinoma","volume":"68","author":"Bast","year":"1981","journal-title":"J Clin Invest"},{"issue":"1","key":"10.1016\/j.ejogrb.2024.03.015_b0025","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s13048-019-0503-7","article-title":"Biomarkers and algorithms for diagnosis of ovarian cancer: CA125, HE4, RMI and ROMA, a review","volume":"12","author":"Dochez","year":"2019","journal-title":"J Ovarian Res"},{"key":"10.1016\/j.ejogrb.2024.03.015_b0030","first-page":"e341","article-title":"Serum levels of the ovarian cancer biomarker HE4 are decreased in pregnancy and increase with age","author":"Moore","year":"20122064349","journal-title":"Am J Obstet Gynecol"},{"issue":"2","key":"10.1016\/j.ejogrb.2024.03.015_b0035","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0378-1119(99)00342-X","article-title":"Comparative hybridization of an array of 21,500 ovarian cDNAs for the discovery of genes overexpressed in ovarian carcinomas","volume":"238","author":"Schummer","year":"1999","journal-title":"Gene"},{"issue":"6","key":"10.1016\/j.ejogrb.2024.03.015_b0040","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.1158\/0008-5472.CAN-04-3924","article-title":"Human epididymis protein 4 (HE4) is a secreted glycoprotein that is overexpressed by serous and endometrioid ovarian carcinomas","volume":"65","author":"Drapkin","year":"2005","journal-title":"Cancer Res"},{"issue":"2","key":"10.1016\/j.ejogrb.2024.03.015_b0045","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.ygyno.2007.10.017","article-title":"The use of multiple novel tumor biomarkers for the detection of ovarian carcinoma in patients with a pelvic mass","volume":"108","author":"Moore","year":"2008","journal-title":"Gynecol Oncol"},{"issue":"1","key":"10.1016\/j.ejogrb.2024.03.015_b0050","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.ygyno.2008.08.031","article-title":"A novel multiple marker bioassay utilizing HE4 and CA125 for the prediction of ovarian cancer in patients with a pelvic mass","volume":"112","author":"Moore","year":"2009","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.ejogrb.2024.03.015_b0055","doi-asserted-by":"crossref","DOI":"10.1136\/ijgc-2019-000211","article-title":"Role of human epididymis protein 4 (HE4) in detecting recurrence in CA125 negative ovarian cancer patients","author":"Plotti","year":"2019","journal-title":"Int J Gynecol Cancer"},{"issue":"8","key":"10.1016\/j.ejogrb.2024.03.015_b0060","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1097\/IGC.0000000000000218","article-title":"The role of HE4 in ovarian cancer follow-up: a review","volume":"24","author":"Piovano","year":"2014","journal-title":"Int J Gynecol Cancer"},{"key":"10.1016\/j.ejogrb.2024.03.015_b0065","doi-asserted-by":"crossref","unstructured":"Moore RG, Plante B, Hartnett E, et al. Assessment of serum HE4 levels throughout the normal menstrual cycle. Am J Obstet Gynecol. 2017;217(1):53 e51-53 e59.","DOI":"10.1016\/j.ajog.2017.02.029"},{"issue":"1","key":"10.1016\/j.ejogrb.2024.03.015_b0070","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s13277-011-0256-4","article-title":"Human epididymis protein 4 reference limits and natural variation in a nordic reference population","volume":"33","author":"Bolstad","year":"2012","journal-title":"Tumour Biol"},{"issue":"5","key":"10.1016\/j.ejogrb.2024.03.015_b0075","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1007\/s00404-020-05527-0","article-title":"The differential diagnostic value and clinical significance of serum HE4 in ovarian disease with elevated CA125","volume":"301","author":"Li","year":"2020","journal-title":"Arch Gynecol Obstet"},{"key":"10.1016\/j.ejogrb.2024.03.015_b0080","unstructured":"Botman SL MT, Moriarty CL, Parons VL. Design and estimation for the National Health Interview Survey, 1995-2004. Vital Health Stat 2. 2000(130):1-31."},{"issue":"2","key":"10.1016\/j.ejogrb.2024.03.015_b0085","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1093\/oxfordjournals.epirev.a017925","article-title":"Cotinine as a biomarker of environmental tobacco smoke exposure","volume":"18","author":"Benowitz","year":"1996","journal-title":"Epidemiol Rev"},{"issue":"12","key":"10.1016\/j.ejogrb.2024.03.015_b0090","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1093\/clinchem\/43.12.2281","article-title":"Development and validation of sensitive method for determination of serum cotinine in smokers and nonsmokers by liquid chromatography\/atmospheric pressure ionization tandem mass spectrometry","volume":"43","author":"Bernert","year":"1997","journal-title":"Clin Chem"},{"issue":"2","key":"10.1016\/j.ejogrb.2024.03.015_b0095","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1093\/aje\/kwn301","article-title":"Optimal serum cotinine levels for distinguishing cigarette smokers and nonsmokers within different racial\/ethnic groups in the United States between 1999 and 2004","volume":"169","author":"Benowitz","year":"2009","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.ejogrb.2024.03.015_b0100","unstructured":"Centers for Disease C, Prevention. Vital signs: nonsmokers' exposure to secondhand smoke --- United States, 1999-2008. MMWR Morb Mortal Wkly Rep. 2010;59(35):1141-1146."},{"issue":"9","key":"10.1016\/j.ejogrb.2024.03.015_b0105","doi-asserted-by":"crossref","first-page":"604","DOI":"10.7326\/0003-4819-150-9-200905050-00006","article-title":"A new equation to estimate glomerular filtration rate","volume":"150","author":"Levey","year":"2009","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.ejogrb.2024.03.015_b0110","doi-asserted-by":"crossref","first-page":"3890906","DOI":"10.1155\/2019\/3890906","article-title":"Human epididymis protein 4 (HE4) reference limits in polish population of healthy women, pregnant women, and women with benign ovarian tumors","volume":"2019","author":"Gasiorowska","year":"2019","journal-title":"Dis Markers"},{"issue":"1","key":"10.1016\/j.ejogrb.2024.03.015_b0115","doi-asserted-by":"crossref","first-page":"15","DOI":"10.5455\/msm.2018.30.15-19","article-title":"Determination of the reference values of the tumor marker HE4 in female population of Canton Sarajevo","volume":"30","author":"Hasanbegovic","year":"2018","journal-title":"Mater Sociomed"},{"issue":"11","key":"10.1016\/j.ejogrb.2024.03.015_b0120","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1158\/1055-9965.EPI-14-0447","article-title":"HE4 tissue expression and serum HE4 levels in healthy individuals and patients with benign or malignant tumors: a systematic review","volume":"23","author":"Karlsen","year":"2014","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"Pt 4","key":"10.1016\/j.ejogrb.2024.03.015_b0125","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1258\/acb.2011.011258","article-title":"Elevated human epididymis protein 4 concentrations in chronic kidney disease","volume":"49","author":"Nagy","year":"2012","journal-title":"Ann Clin Biochem"},{"key":"10.1016\/j.ejogrb.2024.03.015_b0130","doi-asserted-by":"crossref","unstructured":"Moore RG, Miller MC, Steinhoff MM, et al. Serum HE4 levels are less frequently elevated than CA125 in women with benign gynecologic disorders. Am J Obstet Gynecol. 2012;206(4):351 e351-358.","DOI":"10.1016\/j.ajog.2011.12.029"},{"issue":"8","key":"10.1016\/j.ejogrb.2024.03.015_b0135","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1038\/sj.bjc.6605011","article-title":"Serum HE4 concentration differentiates malignant ovarian tumours from ovarian endometriotic cysts","volume":"100","author":"Huhtinen","year":"2009","journal-title":"Br J Cancer"},{"issue":"4","key":"10.1016\/j.ejogrb.2024.03.015_b0140","doi-asserted-by":"crossref","first-page":"5179","DOI":"10.3892\/mmr.2015.4062","article-title":"Comparison of ovarian cancer markers in endometriosis favours HE4 over CA125","volume":"12","author":"McKinnon","year":"2015","journal-title":"Mol Med Rep"},{"key":"10.1016\/j.ejogrb.2024.03.015_b0145","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.cca.2014.08.020","article-title":"Human epididymis protein 4: factors of variation","volume":"438","author":"Ferraro","year":"2015","journal-title":"Clin Chim Acta"}],"container-title":["European Journal of Obstetrics & Gynecology and Reproductive Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211524001350?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211524001350?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T02:31:45Z","timestamp":1757298705000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301211524001350"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":29,"alternative-id":["S0301211524001350"],"URL":"https:\/\/doi.org\/10.1016\/j.ejogrb.2024.03.015","relation":{},"ISSN":["0301-2115"],"issn-type":[{"value":"0301-2115","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Human epididymis protein 4: Analysis of national health and nutrition examination survey data","name":"articletitle","label":"Article Title"},{"value":"European Journal of Obstetrics & Gynecology and Reproductive Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejogrb.2024.03.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}