{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T11:25:27Z","timestamp":1748258727634,"version":"3.40.5"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T00:00:00Z","timestamp":1715817600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","ejog.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Obstetrics &amp; Gynecology and Reproductive Biology"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1016\/j.ejogrb.2024.05.016","type":"journal-article","created":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T15:24:07Z","timestamp":1715873047000},"page":"171-174","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Comparison of single- and double-dose methotrexate protocols for treatment of pregnancy of unknown location"],"prefix":"10.1016","volume":"298","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1764-0747","authenticated-orcid":false,"given":"Magdalena M.","family":"Pir\u00f3g","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Pulka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Przemys\u0142aw","family":"Urbaniec","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Jach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejogrb.2024.05.016_b0005","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1056\/NEJMcp0810384","article-title":"Clinical practice","volume":"361","author":"Barnhart","year":"2009","journal-title":"Ectopic pregnancy N Engl J Med"},{"key":"10.1016\/j.ejogrb.2024.05.016_b0010","first-page":"393","article-title":"Trends in ectopic pregnancy rates following assisted reproductive technologies in the UK: a 12-year nationwide analysis including 160 000 pregnancies","volume":"31","author":"Santos-Ribeiro","year":"2016","journal-title":"Hum Reprod"},{"key":"10.1016\/j.ejogrb.2024.05.016_b0015","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1093\/aje\/kwf190","article-title":"Risk factors for ectopic pregnancy: a comprehensive analysis based on a large case\u2013control, population-based study in France","volume":"157","author":"Bouyer","year":"2003","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.ejogrb.2024.05.016_b0020","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1097\/AOG.0b013e3181d0c328","article-title":"Trends in the diagnosis and treatment of ectopic pregnancy in the United States","volume":"115","author":"Hoover","year":"2010","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ejogrb.2024.05.016_b0025","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1002\/uog.2838","article-title":"Pregnancies of unknown location: consensus statement","volume":"28","author":"Condous","year":"2006","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.ejogrb.2024.05.016_b0030","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1093\/humrep\/deh770","article-title":"The accuracy of transvaginal ultrasonography for the diagnosis of ectopic pregnancy prior to surgery","volume":"20","author":"Condous","year":"2005","journal-title":"Hum Reprod"},{"key":"10.1016\/j.ejogrb.2024.05.016_b0035","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1093\/humrep\/dem073","article-title":"Rationalizing the follow-up of pregnancies of unknown location","volume":"22","author":"Kirk","year":"2007","journal-title":"Hum Reprod"},{"key":"10.1016\/j.ejogrb.2024.05.016_b0040","doi-asserted-by":"crossref","unstructured":"de Bennetot M, Rabischong B, Aublet-Cuvelier B, et al. Fertility after tubal ectopic pregnancy: results of a population-based study. Fertil Steril 2012;98:1271\u20136.e1-3.","DOI":"10.1016\/j.fertnstert.2012.06.041"},{"key":"10.1016\/j.ejogrb.2024.05.016_b0045","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1056\/NEJM200011023431807","article-title":"Nonsurgical treatment of ectopic pregnancy","volume":"343","author":"Lipscomb","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ejogrb.2024.05.016_b0050","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1111\/1471-0528.15442","article-title":"Diagnostic protocols for the management of pregnancy of unknown location: a systematic review and meta-analysis","volume":"126","author":"Bobdiwala","year":"2019","journal-title":"BJOG"},{"key":"10.1016\/j.ejogrb.2024.05.016_b0055","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1093\/humupd\/dmt047","article-title":"Diagnosing ectopic pregnancy and current concepts in the management of pregnancy of unknown location","volume":"20","author":"Kirk","year":"2014","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.ejogrb.2024.05.016_b0060","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.ajog.2019.01.002","article-title":"Two-dose versus single-dose methotrexate for treatment of ectopic pregnancy: a meta-analysis","volume":"221","author":"Alur-Gupta","year":"2019","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ejogrb.2024.05.016_b0065","doi-asserted-by":"crossref","unstructured":"American College of Obstetricians and Gynecologists' Committee on Practice Bulletins \u2013 Gynecology. ACOG Practice Bulletin No. 193: Tubal Ectopic Pregnancy. Obstet Gynecol 2018;131:e91\u2013103.","DOI":"10.1097\/AOG.0000000000002560"},{"key":"10.1016\/j.ejogrb.2024.05.016_b0070","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/S0140-6736(05)67103-6","article-title":"Ectopic pregnancy","volume":"366","author":"Farquhar","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.ejogrb.2024.05.016_b0075","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1056\/NEJM199912233412604","article-title":"Predictors of success of methotrexate treatment in women with tubal ectopic pregnancies","volume":"341","author":"Lipscomb","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ejogrb.2024.05.016_b0080","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.ejogrb.2023.03.024","article-title":"Alternative beta-hCG follow-up protocols after single-dose methotrexate therapy for ectopic pregnancy: a retrospective cohort study","volume":"284","author":"Aiob","year":"2023","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.ejogrb.2024.05.016_b0085","article-title":"Predictors of successful medical management with methotrexate in unruptured tubal ectopic pregnancy","volume":"14","author":"Ray","year":"2022","journal-title":"Cureus"},{"key":"10.1016\/j.ejogrb.2024.05.016_b0090","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.ijgo.2011.08.009","article-title":"Comparison of double- and single-dose methotrexate protocols for treatment of ectopic pregnancy","volume":"116","author":"Hamed","year":"2012","journal-title":"Int J Gynaecol Obstet"},{"key":"10.1016\/j.ejogrb.2024.05.016_b0095","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1093\/humupd\/dmn012","article-title":"Current evidence on surgery, systemic methotrexate and expectant management in the treatment of tubal ectopic pregnancy: a systematic review and meta-analysis","volume":"14","author":"Mol","year":"2008","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.ejogrb.2024.05.016_b0100","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/S0015-0282(00)01547-8","article-title":"Predictors of treatment failure for ectopic pregnancy treated with single-dose methotrexate","volume":"74","author":"Tawfiq","year":"2000","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ejogrb.2024.05.016_b0105","doi-asserted-by":"crossref","first-page":"86","DOI":"10.3346\/jkms.2006.21.1.86","article-title":"Predictors of success of repeated injections of single-dose methotrexate regimen for tubal ectopic pregnancy","volume":"21","author":"Cho","year":"2006","journal-title":"J Korean Med Sci"},{"key":"10.1016\/j.ejogrb.2024.05.016_b0110","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1016\/j.fertnstert.2005.11.055","article-title":"Comparison of success rates in the medical management of ectopic pregnancy with single-dose and multiple-dose administration of methotrexate: a prospective, randomized clinical trial","volume":"85","author":"Alleyassin","year":"2006","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ejogrb.2024.05.016_b0115","first-page":"778","article-title":"The medical management of ectopic pregnancy: a meta-analysis comparing \u201csingle dose\u201d and \u201cmultidose\u201d regimens","volume":"101","author":"Barnhart","year":"2003","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ejogrb.2024.05.016_b0120","doi-asserted-by":"crossref","unstructured":"Committee on Practice Bulletins \u2013 Gynecology. ACOG Practice Bulletin No. 191: Tubal Ectopic Pregnancy. Obstet Gynecol 2018;131:e65\u201377.","DOI":"10.1097\/AOG.0000000000002464"},{"key":"10.1016\/j.ejogrb.2024.05.016_b0125","doi-asserted-by":"crossref","unstructured":"Diagnosis and management of ectopic pregnancy: green-top Guideline No. 21. BJOG 2016;123:e15\u201355.","DOI":"10.1111\/1471-0528.14189"}],"container-title":["European Journal of Obstetrics &amp; Gynecology and Reproductive Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030121152400246X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030121152400246X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T01:15:14Z","timestamp":1718241314000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S030121152400246X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":25,"alternative-id":["S030121152400246X"],"URL":"https:\/\/doi.org\/10.1016\/j.ejogrb.2024.05.016","relation":{},"ISSN":["0301-2115"],"issn-type":[{"type":"print","value":"0301-2115"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparison of single- and double-dose methotrexate protocols for treatment of pregnancy of unknown location","name":"articletitle","label":"Article Title"},{"value":"European Journal of Obstetrics & Gynecology and Reproductive Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejogrb.2024.05.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}