{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T08:58:54Z","timestamp":1771232334448,"version":"3.50.1"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejog.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Obstetrics & Gynecology and Reproductive Biology"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.ejogrb.2024.06.037","type":"journal-article","created":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T20:00:06Z","timestamp":1719518406000},"page":"289-295","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Comparative efficacy of metformin combined with cabergoline versus metformin alone in patients with PCOS and hyperprolactinemia: A systematic review and meta-analysis of randomized controlled trials"],"prefix":"10.1016","volume":"299","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-5157-7725","authenticated-orcid":false,"given":"Misbah","family":"Nizamani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marha","family":"Zaheer uddin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chahat","family":"Nagdev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nusaibah","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alisha","family":"Raza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.ejogrb.2024.06.037_b0005","doi-asserted-by":"crossref","first-page":"583","DOI":"10.3390\/ijms23020583","article-title":"Polycystic ovary syndrome: a comprehensive review of pathogenesis, management, and drug repurposing","volume":"23","author":"Sadeghi","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"3","key":"10.1016\/j.ejogrb.2024.06.037_b0010","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.cnur.2018.04.008","article-title":"Polycystic ovary syndrome","volume":"53","author":"Meier","year":"2018","journal-title":"Nurs Clin North Am"},{"issue":"10","key":"10.1016\/j.ejogrb.2024.06.037_b0015","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1080\/09513590.2021.1958310","article-title":"Polycystic ovarian syndrome and infertility: overview and insights of the putative treatments","volume":"37","author":"Coll\u00e9e","year":"2021","journal-title":"Gynecol Endocrinol"},{"issue":"1","key":"10.1016\/j.ejogrb.2024.06.037_b0020","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s13048-022-01091-0","article-title":"Insulin resistance in polycystic ovary syndrome across various tissues: an updated review of pathogenesis, evaluation, and treatment","volume":"16","author":"Zhao","year":"2023","journal-title":"J Ovarian Res"},{"issue":"1","key":"10.1016\/j.ejogrb.2024.06.037_b0025","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1210\/endrev\/bnaa023","article-title":"Cellular and molecular mechanisms of metformin action","volume":"42","author":"LaMoia","year":"2021","journal-title":"Endocr Rev"},{"issue":"6","key":"10.1016\/j.ejogrb.2024.06.037_b0030","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1042\/CS20110386","article-title":"Cellular and molecular mechanisms of metformin: an overview","volume":"122","author":"Viollet","year":"2012","journal-title":"Clin Sci (Lond)"},{"key":"10.1016\/j.ejogrb.2024.06.037_b0035","doi-asserted-by":"crossref","unstructured":"Cui D, Xu Z, Qiu S, Sun Y. Nasturtium officinale L. and metformin alleviate the estradiol- induced polycystic ovary syndrome with synergistic effects through modulation of Bax\/Bcl2\/p53\/caspase-3 signaling pathway and anti-inflammatory and anti-oxidative effects. J Food Biochem. 2022 Dec;46(12):e14462. doi: 10.1111\/jfbc.14462. Epub 2022 Nov 9.","DOI":"10.1111\/jfbc.14462"},{"issue":"11","key":"10.1016\/j.ejogrb.2024.06.037_b0040","doi-asserted-by":"crossref","first-page":"19964","DOI":"10.1002\/jcp.28594","article-title":"Metformin treatment alleviates polycystic ovary syndrome by decreasing the expression of MMP-2 and MMP-9 via H19\/miR-29b-3p and AKT\/mTOR\/autophagy signaling pathways","volume":"234","author":"Chen","year":"2019","journal-title":"J Cell Physiol"},{"issue":"2","key":"10.1016\/j.ejogrb.2024.06.037_b0045","doi-asserted-by":"crossref","first-page":"255","DOI":"10.2165\/00003495-199549020-00009","article-title":"A review of its pharmacological properties and therapeutic potential in the treatment of hyperprolactinaemia and inhibition of lactation","volume":"49","author":"Rains","year":"1995","journal-title":"Drugs"},{"issue":"1","key":"10.1016\/j.ejogrb.2024.06.037_b0050","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.ando.2020.12.008","article-title":"The risks of medical treatment of prolactinoma","volume":"82","author":"Castinetti","year":"2021","journal-title":"Ann Endocrinol (Paris)"},{"issue":"6","key":"10.1016\/j.ejogrb.2024.06.037_b0055","first-page":"941","article-title":"Idiopathic hyperprolactinemia - a challenge for primary care","volume":"76","author":"Mohamed Juhan","year":"2021","journal-title":"Med J Malaysia"},{"issue":"12","key":"10.1016\/j.ejogrb.2024.06.037_b0060","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1517\/14656566.2013.806488","article-title":"Current treatment options for hyperprolactinemia","volume":"14","author":"Faje","year":"2013","journal-title":"Expert Opin Pharmacother"},{"issue":"4","key":"10.1016\/j.ejogrb.2024.06.037_b0065","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1530\/REP-18-0027","article-title":"Dysregulated genes and their functional pathways in luteinized granulosa cells from PCOS patients after cabergoline treatment","volume":"155","author":"Ferrero","year":"2018","journal-title":"Reproduction"},{"issue":"339","key":"10.1016\/j.ejogrb.2024.06.037_b0070","article-title":"The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration","volume":"21","author":"Liberati","year":"2009","journal-title":"BMJ"},{"key":"10.1016\/j.ejogrb.2024.06.037_b0075","article-title":"RoB 2: a revised cochrane risk-of-bias tool for randomized trials","volume":"1\u201324","author":"Sterne","year":"2019","journal-title":"BMJ"},{"issue":"1","key":"10.1016\/j.ejogrb.2024.06.037_b0080","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/j.1467-985X.2008.00552.x","article-title":"A re-evaluation of random-effects meta-analysis","volume":"172","author":"Higgins","year":"2009","journal-title":"J R Stat Soc Ser A Stat Soc"},{"issue":"2","key":"10.1016\/j.ejogrb.2024.06.037_b0085","first-page":"93","article-title":"Cabergoline plus metformin therapy effects on menstrual irregularity and androgen system in polycystic ovary syndrome women with hyperprolactinemia","volume":"13","author":"Ghaneei","year":"2015","journal-title":"Iran J Reprod Med"},{"issue":"5","key":"10.1016\/j.ejogrb.2024.06.037_b0090","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/s13224-017-1022-3","article-title":"Efficacy of combined cabergoline and metformin compared to metformin alone on cycle regularity in patients with polycystic ovarian disease with hyperprolactinemia: a randomized clinical trial","volume":"67","author":"Elsersy","year":"2017","journal-title":"J Obstet Gynaecol India"},{"issue":"11","key":"10.1016\/j.ejogrb.2024.06.037_b0095","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.25122\/jml-2023-0317","article-title":"Effects of combined metformin and cabergoline versus metformin alone on ovarian and hormonal activities in Iraqi patients with PCOS and hyperprolactinemia: a randomized clinical trial","volume":"16","author":"Hamad","year":"2023","journal-title":"J Med Life"},{"issue":"13","key":"10.1016\/j.ejogrb.2024.06.037_b0100","article-title":"PCOS and Hyperprolactinemia: what do we know in 2019?","volume":"9","author":"Delcour","year":"2019","journal-title":"Clin Med Insights Reprod Health"},{"issue":"8","key":"10.1016\/j.ejogrb.2024.06.037_b0105","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1111\/j.1471-0528.1976.tb00895.x","article-title":"Polycystic ovarian disease","volume":"83","author":"Duignan","year":"1976","journal-title":"Br J Obstet Gynaecol"},{"issue":"5916","key":"10.1016\/j.ejogrb.2024.06.037_b0110","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1136\/bmj.2.5916.419","article-title":"Long-term treatment of galactorrhoea and hypogonadism with bromocriptine","volume":"2","author":"Thorner","year":"1974","journal-title":"Br Med J"},{"issue":"2","key":"10.1016\/j.ejogrb.2024.06.037_b0115","doi-asserted-by":"crossref","first-page":"e817","DOI":"10.1210\/clinem\/dgad465","article-title":"Metformin and combined oral contraceptive pills in the management of polycystic ovary syndrome: a systematic review and meta-analysis","volume":"109","author":"Melin","year":"2024","journal-title":"J Clin Endocrinol Metab"},{"issue":"7","key":"10.1016\/j.ejogrb.2024.06.037_b0120","doi-asserted-by":"crossref","first-page":"506","DOI":"10.3109\/09513590.2015.1017810","article-title":"Hyperprolactinemia: pathophysiology and therapeutic approach","volume":"31","author":"Capozzi","year":"2015","journal-title":"Gynecolog Endocrinol: Off J Int Soc Gynecolog Endocrinol"},{"issue":"2","key":"10.1016\/j.ejogrb.2024.06.037_b0125","first-page":"341","article-title":"Hyperprolactinaemia. Best practice & research","volume":"22","author":"Prabhakar","year":"2008","journal-title":"Clinical obstetrics & gynaecology"},{"issue":"6","key":"10.1016\/j.ejogrb.2024.06.037_b0130","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1210\/jc.2009-2605","article-title":"Individualized high-dose cabergoline therapy for hyperprolactinemic infertility in women with micro- and macroprolactinomas","volume":"95","author":"Ono","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"issue":"10","key":"10.1016\/j.ejogrb.2024.06.037_b0135","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1093\/ajhp\/zxab065","article-title":"Guidance on the treatment of antipsychotic-induced hyperprolactinemia when switching the antipsychotic is not an option","volume":"78","author":"Rusgis","year":"2021","journal-title":"Am J Health Syst Pharm"},{"issue":"4","key":"10.1016\/j.ejogrb.2024.06.037_b0140","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/BF03348155","article-title":"Acute effects of L-dopa and bromocriptine on serum PRL, LH and FSH levels in patients with hyperprolactinemic and normoprolactinemic polycystic ovary syndrome","volume":"10","author":"Prelevi\u0107","year":"1987","journal-title":"J Endocrinol Invest"},{"issue":"9","key":"10.1016\/j.ejogrb.2024.06.037_b0145","doi-asserted-by":"crossref","first-page":"3208","DOI":"10.3390\/jcm12093208","article-title":"Cardiometabolic Effects of Cabergoline and Combined Oral Contraceptive Pills in Young Women with Hyperprolactinemia: A Pilot Study","volume":"12","author":"Krysiak","year":"2023","journal-title":"J Clin Med"},{"issue":"4","key":"10.1016\/j.ejogrb.2024.06.037_b0150","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1038\/oby.2010.150","article-title":"BMI and metabolic profile in patients with prolactinoma before and after treatment with dopamine agonists","volume":"19","author":"dos Santos Silva","year":"2011","journal-title":"Obesity (Silver Spring, Md)"},{"issue":"2","key":"10.1016\/j.ejogrb.2024.06.037_b0155","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1007\/s13679-019-00335-3","article-title":"Metformin: Mechanisms in Human Obesity and Weight Loss","volume":"8","author":"Yerevanian","year":"2019","journal-title":"Curr Obes Rep"},{"issue":"8","key":"10.1016\/j.ejogrb.2024.06.037_b0160","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1038\/s42255-019-0099-7","article-title":"Hypothalamic dopamine signaling regulates brown fat thermogenesis","volume":"1","author":"Folgueira","year":"2019","journal-title":"Nat Metab"},{"key":"10.1016\/j.ejogrb.2024.06.037_b0165","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1186\/s13098-015-0094-4","article-title":"Metabolic abnormalities in patients with prolactinoma: response to treatment with cabergoline","volume":"7","author":"Pala","year":"2015","journal-title":"Diabetol Metab Syndr"},{"issue":"4","key":"10.1016\/j.ejogrb.2024.06.037_b0170","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/S0015-0282(16)58563-X","article-title":"The chronic administration of cabergoline normalizes androgen secretion and improves menstrual cyclicity in women with polycystic ovary syndrome","volume":"66","author":"Paoletti","year":"1996","journal-title":"Fertil Steril"},{"issue":"1","key":"10.1016\/j.ejogrb.2024.06.037_b0175","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.fertnstert.2003.05.020","article-title":"Metformin administration modulates and restores luteinizing hormone spontaneous episodic secretion and ovarian function in nonobese patients with polycystic ovary syndrome","volume":"81","author":"Genazzani","year":"2004","journal-title":"Fertil Steril"},{"issue":"8","key":"10.1016\/j.ejogrb.2024.06.037_b0180","doi-asserted-by":"crossref","first-page":"3595","DOI":"10.1210\/jcem.86.8.7756","article-title":"Sensitization to insulin induces ovulation in nonobese adolescents with anovulatory hyperandrogenism","volume":"86","author":"Ib\u00e1\u00f1ez","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.ejogrb.2024.06.037_b0185","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/s12291-010-0090-2","article-title":"Effect of metformin on hormonal and biochemical profile in PCOS before and after therapy","volume":"25","author":"Singh","year":"2010","journal-title":"Indian J Clin Biochem"},{"issue":"1","key":"10.1016\/j.ejogrb.2024.06.037_b0190","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1080\/gye.17.1.51.56","article-title":"Effects of metformin therapy on hyperandrogenism in women with polycystic ovarian syndrome","volume":"17","author":"Kazerooni","year":"2003","journal-title":"Gynecolog Endocrinol: Off J Int Soc Gynecolog Endocrinol"},{"issue":"5","key":"10.1016\/j.ejogrb.2024.06.037_b0195","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1111\/j.1365-2265.1987.tb01187.x","article-title":"Effect of bromocriptine on LH pulsatility in the polycystic ovary syndrome","volume":"27","author":"Chapman","year":"1987","journal-title":"Clin Endocrinol"}],"container-title":["European Journal of Obstetrics & Gynecology and Reproductive Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211524003269?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211524003269?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T22:56:49Z","timestamp":1759964209000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301211524003269"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":39,"alternative-id":["S0301211524003269"],"URL":"https:\/\/doi.org\/10.1016\/j.ejogrb.2024.06.037","relation":{},"ISSN":["0301-2115"],"issn-type":[{"value":"0301-2115","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparative efficacy of metformin combined with cabergoline versus metformin alone in patients with PCOS and hyperprolactinemia: A systematic review and meta-analysis of randomized controlled trials","name":"articletitle","label":"Article Title"},{"value":"European Journal of Obstetrics & Gynecology and Reproductive Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejogrb.2024.06.037","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}