{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T17:57:24Z","timestamp":1794074244214,"version":"4.8.0"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,7,6]],"date-time":"2024-07-06T00:00:00Z","timestamp":1720224000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100024370","name":"Ministero dell'Istruzione dell'Universita e della Ricerca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100024370","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003407","name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","award":["2017728JPK"],"award-info":[{"award-number":["2017728JPK"]}],"id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejog.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Obstetrics &amp; Gynecology and Reproductive Biology"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.ejogrb.2024.07.004","type":"journal-article","created":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T16:39:16Z","timestamp":1720024756000},"page":"63-68","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Multiple births from medically assisted reproduction: contribution of different types of procedures and trends over time"],"prefix":"10.1016","volume":"300","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7894-4456","authenticated-orcid":false,"given":"Giovanna","family":"Esposito","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Parazzini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Vigan\u00f2","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Cantarutti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Franchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Corrao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"La Vecchia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edgardo","family":"Somigliana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejogrb.2024.07.004_b0005","doi-asserted-by":"crossref","first-page":"2832","DOI":"10.1093\/humrep\/deaa250","article-title":"20 years of the European IVF-monitoring Consortium registry: what have we learned? A comparison with registries from two other regions","volume":"35","author":"De Geyter","year":"2020","journal-title":"Hum Reprod"},{"key":"10.1016\/j.ejogrb.2024.07.004_b0010","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1056\/NEJM199808273390901","article-title":"Reducing the risk of multiple births by transfer of two embryos after in vitro fertilization","volume":"339","author":"Templeton","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ejogrb.2024.07.004_b0015","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1056\/NEJMsa032073","article-title":"Trends in embryo-transfer practice and in outcomes of the use of assisted reproductive technology in the United States","volume":"350","author":"Jain","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ejogrb.2024.07.004_b0020","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.fertnstert.2004.05.095","article-title":"Use of a prediction model for high-order multiple implantation after ovarian stimulation with gonadotropins","volume":"83","author":"Tur","year":"2005","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ejogrb.2024.07.004_b0025","doi-asserted-by":"crossref","DOI":"10.4414\/smw.2021.20499","article-title":"Single embryo transfer in all infertile couples treated with assisted reproduction produces excellent results and avoids multiple births","volume":"151","author":"De Geyter","year":"2021","journal-title":"Swiss Med Wkly"},{"key":"10.1016\/j.ejogrb.2024.07.004_b0030","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.fertnstert.2020.07.022","article-title":"Strategies to reduce multiple pregnancies during medically assisted reproduction","volume":"114","author":"Bergh","year":"2020","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ejogrb.2024.07.004_b0035","first-page":"CD003416","article-title":"Number of embryos for transfer following in vitro fertilisation or intra-cytoplasmic sperm injection","volume":"8","author":"Kamath","year":"2020","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.ejogrb.2024.07.004_b0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/hta14380","article-title":"Towards single embryo transfer? Modelling clinical outcomes of potential treatment choices using multiple data sources: predictive models and patient perspectives","volume":"14","author":"Roberts","year":"2010","journal-title":"Health Technol Assess"},{"key":"10.1016\/j.ejogrb.2024.07.004_b0045","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1093\/humrep\/den355","article-title":"Modelling the impact of single embryo transfer in a national health service IVF programme","volume":"24","author":"Roberts","year":"2009","journal-title":"Hum Reprod"},{"key":"10.1016\/j.ejogrb.2024.07.004_b0050","unstructured":"Practice Committee of the Society for Reproductive E, Infertility QACotSfART, the Practice Committee of the American Society for Reproductive Medicine. Electronic address aao. Multiple gestation associated with infertility therapy: a committee opinion. Fertil Steril. 2022;117:498-511."},{"key":"10.1016\/j.ejogrb.2024.07.004_b0055","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.ejogrb.2022.09.003","article-title":"The changing impact of assisted reproductive techniques on preterm birth during the period 2007\u20132020 in Lombardy, Northern Italy","volume":"278","author":"Esposito","year":"2022","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.ejogrb.2024.07.004_b0060","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1056\/NEJM200007063430101","article-title":"Reducing the risk of high-order multiple pregnancy after ovarian stimulation with gonadotropins","volume":"343","author":"Gleicher","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ejogrb.2024.07.004_b0065","doi-asserted-by":"crossref","unstructured":"Practice Committee of American Society for Reproductive M. Multiple gestation associated with infertility therapy: an American Society for Reproductive Medicine Practice Committee opinion. Fertil Steril. 2012;97:825-34.","DOI":"10.1016\/j.fertnstert.2011.11.048"},{"key":"10.1016\/j.ejogrb.2024.07.004_b0070","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/S0015-0282(02)04561-2","article-title":"A year of inaction on high-order multiple pregnancies due to ovulation induction","volume":"79","author":"Dickey","year":"2003","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ejogrb.2024.07.004_b0075","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1002\/hec.1776","article-title":"The effects of insurance mandates on choices and outcomes in infertility treatment markets","volume":"21","author":"Hamilton","year":"2012","journal-title":"Health Econ"},{"key":"10.1016\/j.ejogrb.2024.07.004_b0080","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1056\/NEJMsa013491","article-title":"Insurance coverage and outcomes of in vitro fertilization","volume":"347","author":"Jain","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ejogrb.2024.07.004_b0085","doi-asserted-by":"crossref","unstructured":"Practice Committee of the American Society for Reproductive M, the Practice Committee for the Society for Assisted Reproductive Technologies. Electronic address Aao. Guidance on the limits to the number of embryos to transfer: a committee opinion. Fertil Steril. 2021;116:651-4.","DOI":"10.1016\/j.fertnstert.2021.06.050"},{"key":"10.1016\/j.ejogrb.2024.07.004_b0090","unstructured":"Resolve. Infertility coverage by state. Available at: https:\/\/resolve.org\/what-are-my-options\/insurance-coverage\/infertility-coverage-state (Accessed June 10, 2024)."},{"issue":"403\u20139","key":"10.1016\/j.ejogrb.2024.07.004_b0095","first-page":"e1","article-title":"Embryo transfer practices and perinatal outcomes by insurance mandate status","volume":"104","author":"Boulet","year":"2015","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ejogrb.2024.07.004_b0100","unstructured":"ISS. Fertilit\u00e0. Available at: https:\/\/www.iss.it\/fertilita (Accessed June 10, 2024)."},{"key":"10.1016\/j.ejogrb.2024.07.004_b0105","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1093\/humrep\/dey242","article-title":"ART in Europe, 2014: results generated from European registries by ESHRE: The European IVF-monitoring Consortium (EIM) for the European Society of Human Reproduction and Embryology (ESHRE)","volume":"33","author":"De Geyter","year":"2018","journal-title":"Hum Reprod"},{"key":"10.1016\/j.ejogrb.2024.07.004_b0110","first-page":"179","article-title":"Single-embryo transfer: a key strategy to reduce the risk for multiple pregnancy in assisted human reproduction","volume":"2","author":"Reimundo","year":"2021","journal-title":"Adv Lab Med"},{"key":"10.1016\/j.ejogrb.2024.07.004_b0115","doi-asserted-by":"crossref","unstructured":"European IVF Monitoring Consortium (EIM) for the European Society of Human Reproduction and Embryology (ESHRE); Smeenk J, Wyns C, De Geyter C, Kupka M, Bergh C, Cuevas Saiz I, De Neubourg D, Rezabek K, Tandler-Schneider A, Rugescu I, Goossens V. ART in Europe, 2019: results generated from European registries by ESHRE\u2020. Hum Reprod. 2023 Dec 4;38(12):2321-2338.","DOI":"10.1093\/humrep\/dead197"},{"key":"10.1016\/j.ejogrb.2024.07.004_b0120","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1016\/j.fertnstert.2007.01.112","volume":"88","author":"Dickey","year":"2007","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ejogrb.2024.07.004_b0125","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1111\/j.1471-0528.2004.00439.x","article-title":"Low dose recombinant FSH treatment may reduce multiple gestations caused by controlled ovarian hyperstimulation and intrauterine insemination","volume":"111","author":"Papageorgiou","year":"2004","journal-title":"BJOG"},{"key":"10.1016\/j.ejogrb.2024.07.004_b0130","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1093\/humrep\/deh023","article-title":"GnRH antagonists and mild ovarian stimulation for intrauterine insemination: a randomized study comparing different gonadotrophin dosages","volume":"19","author":"Ragni","year":"2004","journal-title":"Hum Reprod"},{"key":"10.1016\/j.ejogrb.2024.07.004_b0135","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.fertnstert.2005.09.021","article-title":"Preventing high-order multiple pregnancies during controlled ovarian hyperstimulation and intrauterine insemination: 3 years' experience using low-dose recombinant follicle-stimulating hormone and gonadotropin-releasing hormone antagonists","volume":"85","author":"Ragni","year":"2006","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ejogrb.2024.07.004_b0140","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.fertnstert.2008.08.008","article-title":"Strategies to reduce multiple pregnancies due to ovulation stimulation","volume":"91","author":"Dickey","year":"2009","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ejogrb.2024.07.004_b0145","unstructured":"Royal College of Obstetricians and Gynaecologists Evidence-based Clinical Guidelines. Guideline Summary No. 3: the management of infertility in secondary care. BJU Int. 1999;83:641-5."},{"key":"10.1016\/j.ejogrb.2024.07.004_b0150","unstructured":"American College of O, Gynecologists. ACOG practice bulletin. Management of infertility caused by ovulatory dysfunction. Number 34, February 2002. American College of Obstetricians and Gynecologists. Int J Gynaecol Obstet. 2002;77:177-88."},{"key":"10.1016\/j.ejogrb.2024.07.004_b0155","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S1521-6934(02)00127-X","article-title":"Prevention and treatment of ovarian hyperstimulation syndrome","volume":"17","author":"Al-Shawaf","year":"2003","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"10.1016\/j.ejogrb.2024.07.004_b0160","first-page":"CD005289","article-title":"Monitoring of stimulated cycles in assisted reproduction (IVF and ICSI)","volume":"4","author":"Kwan","year":"2021","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.ejogrb.2024.07.004_b0165","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1002\/uog.12566","article-title":"Ultrasound for monitoring controlled ovarian stimulation: a systematic review and meta-analysis of randomized controlled trials","volume":"43","author":"Martins","year":"2014","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.ejogrb.2024.07.004_b0170","doi-asserted-by":"crossref","DOI":"10.1093\/hropen\/hoad035","article-title":"Risk factors associated with monozygotic twinning in offspring conceived by assisted reproductive technology","author":"Chen","year":"2023","journal-title":"Hum Reprod Open"},{"key":"10.1016\/j.ejogrb.2024.07.004_b0175","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1093\/humrep\/dew216","article-title":"Do ARTs affect the incidence of monozygotic twinning?","volume":"31","author":"Mateizel","year":"2016","journal-title":"Hum Reprod"}],"container-title":["European Journal of Obstetrics &amp; Gynecology and Reproductive Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211524003397?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211524003397?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T19:12:59Z","timestamp":1762456379000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301211524003397"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":35,"alternative-id":["S0301211524003397"],"URL":"https:\/\/doi.org\/10.1016\/j.ejogrb.2024.07.004","relation":{},"ISSN":["0301-2115"],"issn-type":[{"value":"0301-2115","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multiple births from medically assisted reproduction: contribution of different types of procedures and trends over time","name":"articletitle","label":"Article Title"},{"value":"European Journal of Obstetrics & Gynecology and Reproductive Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejogrb.2024.07.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}