{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T17:53:29Z","timestamp":1792691609916,"version":"4.5.0"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T00:00:00Z","timestamp":1720051200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010711","name":"Cancer Foundation Finland","doi-asserted-by":"publisher","award":["WBS4708719"],"award-info":[{"award-number":["WBS4708719"]}],"id":[{"id":"10.13039\/501100010711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008376","name":"Helsingin ja Uudenmaan Sairaanhoitopiiri","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008376","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007797","name":"University of Helsinki","doi-asserted-by":"publisher","award":["TYH2020302"],"award-info":[{"award-number":["TYH2020302"]}],"id":[{"id":"10.13039\/100007797","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejog.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Obstetrics & Gynecology and Reproductive Biology"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.ejogrb.2024.07.007","type":"journal-article","created":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T13:40:40Z","timestamp":1720100440000},"page":"23-28","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Asparaginase-like protein 1 as a prognostic tissue biomarker in clinicopathologically and molecularly characterized endometrial cancer"],"prefix":"10.1016","volume":"300","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4372-2367","authenticated-orcid":false,"given":"Mikko J.","family":"Loukovaara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jutta K.","family":"Huvila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annukka M.","family":"Pasanen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf C.","family":"B\u00fctzow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejogrb.2024.07.007_b0005","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1002\/mrd.10092","article-title":"A Novel asparaginase-like protein is a sperm autoantigen in rats","volume":"62","author":"Bush","year":"2002","journal-title":"Mol Reprod Dev"},{"key":"10.1016\/j.ejogrb.2024.07.007_b0010","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/j.1365-2249.1990.tb05473.x","article-title":"Modulation of lymphocyte proliferation by enzymes that degrade amino acids","volume":"82","author":"Chuang","year":"1990","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.ejogrb.2024.07.007_b0015","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1006\/excr.1995.1317","article-title":"Characterization of apoptotic phenomena induced by treatment with L-asparaginase in NIH3T3 cells","volume":"220","author":"Bussolati","year":"1995","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.ejogrb.2024.07.007_b0020","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1111\/1471-0528.15403","article-title":"Asparaginase-like protein 1 expression in curettage independently predicts lymph node metastasis in endometrial carcinoma: a multicentre study","volume":"125","author":"Fonnes","year":"2018","journal-title":"BJOG"},{"key":"10.1016\/j.ejogrb.2024.07.007_b0025","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.ygyno.2015.03.055","article-title":"Loss of ASRGL1 expression is an independent biomarker for disease-specific survival in endometrioid endometrial carcinoma","volume":"137","author":"Edqvist","year":"2015","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.ejogrb.2024.07.007_b0030","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.ygyno.2017.10.025","article-title":"Asparaginase-like protein 1 is an independent prognostic marker in primary endometrial cancer, and is frequently lost in metastatic lesions","volume":"148","author":"Fonnes","year":"2018","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.ejogrb.2024.07.007_b0035","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/nature12113","article-title":"Integrated genomic characterization of endometrial carcinoma","volume":"497","author":"The Cancer Genome Atlas Research Network","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.ejogrb.2024.07.007_b0040","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.ygyno.2019.08.019","article-title":"TCGA molecular groups of endometrial cancer: pooled data about prognosis","volume":"155","author":"Raffone","year":"2019","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.ejogrb.2024.07.007_b0045","doi-asserted-by":"crossref","first-page":"4215","DOI":"10.1158\/1078-0432.CCR-15-2878","article-title":"Improved risk assessment by integrating molecular and clinicopathological factors in early-stage endometrial cancer \u2013 combined analysis of the PORTEC cohorts","volume":"22","author":"Stelloo","year":"2016","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.ejogrb.2024.07.007_b0050","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1038\/s41379-020-0501-8","article-title":"Clinicopathological significance of deficient DNA mismatch repair and MLH1 promoter methylation in endometrioid endometrial carcinoma","volume":"33","author":"Pasanen","year":"2020","journal-title":"Mod Pathol"},{"key":"10.1016\/j.ejogrb.2024.07.007_b0055","doi-asserted-by":"crossref","first-page":"3124","DOI":"10.3390\/cancers13133124","article-title":"Mismatch repair deficiency as a predictive and prognostic biomarker in molecularly classified endometrial carcinoma","volume":"13","author":"Loukovaara","year":"2021","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.ejogrb.2024.07.007_b0060","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1136\/jclinpath-2022-208345","article-title":"Molecular classification of endometrial carcinoma: a clinically oriented review","volume":"75","author":"Loukovaara","year":"2022","journal-title":"J Clin Pathol"},{"key":"10.1016\/j.ejogrb.2024.07.007_b0065","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1136\/ijgc-2020-002230","article-title":"ESGO\/ESTRO\/ESP guidelines for the management of patients with endometrial carcinoma","volume":"31","author":"Concin","year":"2021","journal-title":"Int J Gynecol Cancer"},{"key":"10.1016\/j.ejogrb.2024.07.007_b0070","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.ijgo.2009.02.012","article-title":"Revised FIGO staging for carcinoma of the vulva, cervix, and endometrium","volume":"105","author":"Pecorelli","year":"2009","journal-title":"Int J Gynaecol Obstet"},{"key":"10.1016\/j.ejogrb.2024.07.007_b0075","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1093\/jnci\/djt144","article-title":"L1CAM in early-stage type I endometrial cancer: results of a large multicenter evaluation","volume":"105","author":"Zeimet","year":"2013","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.ejogrb.2024.07.007_b0080","doi-asserted-by":"crossref","first-page":"2602","DOI":"10.1016\/j.ejca.2014.07.014","article-title":"L1 cell adhesion molecule is a strong predictor for distant recurrence and overall survival in early stage endometrial cancer: pooled PORTEC trial results","volume":"50","author":"Bosse","year":"2014","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.ejogrb.2024.07.007_b0085","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1097\/IGC.0000000000000801","article-title":"L1 cell adhesion molecule as a predictor of disease-specific survival and patterns of relapse in endometrial cancer","volume":"26","author":"Pasanen","year":"2016","journal-title":"Int J Gynecol Cancer"},{"key":"10.1016\/j.ejogrb.2024.07.007_b0090","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.ygyno.2008.10.032","article-title":"Expression of estrogen receptor-alpha and -beta and progesterone receptor-A and -B in a large cohort of patients with endometrioid endometrial cancer","volume":"112","author":"Jongen","year":"2009","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.ejogrb.2024.07.007_b0095","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1097\/PAS.0000000000001395","article-title":"PD-L1 expression in endometrial carcinoma cells and intratumoral immune cells: differences across histologic and TCGA-based molecular subgroups","volume":"44","author":"Pasanen","year":"2020","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.ejogrb.2024.07.007_b0100","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/bjc.2015.190","article-title":"A clinically applicable molecular-based classification for endometrial cancers","volume":"113","author":"Talhouk","year":"2015","journal-title":"Br J Cancer"},{"key":"10.1016\/j.ejogrb.2024.07.007_b0105","doi-asserted-by":"crossref","first-page":"159","DOI":"10.2307\/2529310","article-title":"The measurement of observer agreement for categorical data","volume":"33","author":"Landis","year":"1977","journal-title":"Biometrics"},{"key":"10.1016\/j.ejogrb.2024.07.007_b0110","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.ygyno.2016.02.003","article-title":"L1CAM is an independent predictor of poor survival in endometrial cancer \u2013 an analysis of The Cancer Genome Atlas (TCGA)","volume":"141","author":"Dellinger","year":"2016","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.ejogrb.2024.07.007_b0115","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.ygyno.2018.07.020","article-title":"Molecular-integrated risk profile to determine adjuvant radiotherapy in endometrial cancer: evaluation of the pilot phase of the PORTEC-4a trial","volume":"151","author":"Wortman","year":"2018","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.ejogrb.2024.07.007_b0120","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1200\/JCO.23.00470","article-title":"Redefining the position of hormonal therapy in endometrial cancer in the era of molecular classification","volume":"42","author":"Pijnenborg","year":"2023","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ejogrb.2024.07.007_b0125","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.ygyno.2018.02.016","article-title":"Combined ASRGL1 and p53 immunohistochemistry as an independent predictor of survival in endometrioid endometrial carcinoma","volume":"149","author":"Huvila","year":"2018","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.ejogrb.2024.07.007_b0130","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1097\/PGP.0000000000000841","article-title":"A multiplex SNaPshot assay is a rapid and cost-effective method for detecting POLE exonuclease domain mutations in endometrial carcinoma","volume":"41","author":"Devereaux","year":"2022","journal-title":"Int J Gynecol Pathol"},{"issue":"2","key":"10.1016\/j.ejogrb.2024.07.007_b0135","doi-asserted-by":"crossref","first-page":"e15","DOI":"10.3802\/jgo.2022.33.e15","article-title":"Clinical evaluation of a droplet digital PCR assay for detecting POLE mutations and molecular classification of endometrial cancer","volume":"33","author":"Kim","year":"2022","journal-title":"J Gynecol Oncol"},{"key":"10.1016\/j.ejogrb.2024.07.007_b0140","doi-asserted-by":"crossref","first-page":"e2200384","DOI":"10.1200\/GO.22.00384","article-title":"QPOLE: a quick, simple, and cheap alternative for POLE sequencing in endometrial cancer by multiplex genotyping quantitative polymerase chain reaction","volume":"9","author":"Van den Heerik","year":"2023","journal-title":"JCO Glob Oncol"}],"container-title":["European Journal of Obstetrics & Gynecology and Reproductive Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211524003427?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211524003427?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T19:12:11Z","timestamp":1762456331000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301211524003427"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":28,"alternative-id":["S0301211524003427"],"URL":"https:\/\/doi.org\/10.1016\/j.ejogrb.2024.07.007","relation":{},"ISSN":["0301-2115"],"issn-type":[{"value":"0301-2115","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Asparaginase-like protein 1 as a prognostic tissue biomarker in clinicopathologically and molecularly characterized endometrial cancer","name":"articletitle","label":"Article Title"},{"value":"European Journal of Obstetrics & Gynecology and Reproductive Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejogrb.2024.07.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}