{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T14:57:46Z","timestamp":1793113066244,"version":"4.5.0"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T00:00:00Z","timestamp":1725321600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","ejog.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Obstetrics & Gynecology and Reproductive Biology"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.ejogrb.2024.09.003","type":"journal-article","created":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T17:14:01Z","timestamp":1725642841000},"page":"111-115","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Optimization of HPV-positive women triage with p16\/Ki67 dual staining cytology in an organized cervical cancer screening program in the center region of Portugal"],"prefix":"10.1016","volume":"302","author":[{"given":"B\u00e1rbara","family":"Sepodes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Rebelo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9591-1039","authenticated-orcid":false,"given":"Duarte","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Catal\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda","family":"\u00c1guas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gra\u00e7a","family":"Fernandes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.ejogrb.2024.09.003_b0005","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J Clin"},{"issue":"2","key":"10.1016\/j.ejogrb.2024.09.003_b0010","doi-asserted-by":"crossref","first-page":"E197","DOI":"10.1016\/S2214-109X(22)00501-0","article-title":"Global estimates of incidence and mortality of cervical cancer in 2020: a baseline analysis of the WHO global cervical cancer elimination initiative","volume":"11","author":"Singh","year":"2023","journal-title":"Lancet Glob Health"},{"key":"10.1016\/j.ejogrb.2024.09.003_b0015","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.bpobgyn.2017.08.006","article-title":"Epidemiology and burden of HPV-related disease","volume":"47","author":"Serrano","year":"2018","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"issue":"11","key":"10.1016\/j.ejogrb.2024.09.003_b0020","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1016\/S1470-2045(10)70230-8","article-title":"Human papillomavirus genotype attribution in invasive cervical cancer: a retrospective cross-sectional worldwide study","volume":"11","author":"de Sanjose","year":"2010","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.ejogrb.2024.09.003_b0025","unstructured":"IARC. Carvical Cancer Screening. IARC Handbooks of Cancer Prevention. Lyon (FR) 2022."},{"issue":"11","key":"10.1016\/j.ejogrb.2024.09.003_b0030","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1086\/516784","article-title":"A 2-year prospective study of human papillomavirus persistence among women with a cytological diagnosis of atypical squamous cells of undetermined significance or low-grade squamous intraepithelial lesion","volume":"195","author":"Plummer","year":"2007","journal-title":"J Infect Dis"},{"issue":"9590","key":"10.1016\/j.ejogrb.2024.09.003_b0035","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1016\/S0140-6736(07)61416-0","article-title":"Human papillomavirus and cervical cancer","volume":"370","author":"Schiffman","year":"2007","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.ejogrb.2024.09.003_b0040","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.mcna.2022.10.006","article-title":"Cervical cancer screening","volume":"107","author":"Gavinski","year":"2023","journal-title":"Med Clin North Am"},{"issue":"11","key":"10.1016\/j.ejogrb.2024.09.003_b0045","article-title":"Cervical cancer: early detection and prevention in reproductive age group","volume":"14","author":"Basoya","year":"2022","journal-title":"Cureus"},{"issue":"3","key":"10.1016\/j.ejogrb.2024.09.003_b0050","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1002\/ijc.33812","article-title":"Clinical validation of p16\/Ki-67 dual-stained cytology triage of HPV-positive women: results from the IMPACT trial","volume":"150","author":"Wright","year":"2022","journal-title":"Int J Cancer"},{"issue":"7","key":"10.1016\/j.ejogrb.2024.09.003_b0055","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1001\/jamainternmed.2019.0306","article-title":"Clinical evaluation of human papillomavirus screening With p16\/Ki-67 dual stain triage in a large organized cervical cancer screening program","volume":"179","author":"Wentzensen","year":"2019","journal-title":"JAMA Intern Med"},{"issue":"9","key":"10.1016\/j.ejogrb.2024.09.003_b0060","doi-asserted-by":"crossref","first-page":"2599","DOI":"10.1002\/ijc.32669","article-title":"Approaches to triage optimization in HPV primary screening: extended genotyping and p16\/Ki-67 dual-stained cytology-Retrospective insights from ATHENA","volume":"146","author":"Stoler","year":"2020","journal-title":"Int J Cancer"},{"issue":"2","key":"10.1016\/j.ejogrb.2024.09.003_b0065","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1001\/jamaoncol.2018.4270","article-title":"Five-year risk of cervical precancer following p16\/Ki-67 dual-stain triage of HPV-positive women","volume":"5","author":"Clarke","year":"2019","journal-title":"JAMA Oncol"},{"issue":"1","key":"10.1016\/j.ejogrb.2024.09.003_b0070","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1186\/s12889-019-6536-4","article-title":"Budget impact analysis of cervical cancer screening in Portugal: comparison of cytology and primary HPV screening strategies","volume":"19","author":"Pista","year":"2019","journal-title":"BMC Public Health"},{"issue":"7","key":"10.1016\/j.ejogrb.2024.09.003_b0075","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1158\/1940-6207.CAPR-22-0455","article-title":"Cost-effectiveness of p16\/Ki-67 dual-stained cytology reflex following co-testing with hrHPV genotyping for cervical cancer screening","volume":"16","author":"Harper","year":"2023","journal-title":"Cancer Prev Res (Phila)"},{"key":"10.1016\/j.ejogrb.2024.09.003_b0080","unstructured":"WHO WHO. Global strategy to accelerate the elimination of cervical cancer as a public health problem. 2020."},{"issue":"1","key":"10.1016\/j.ejogrb.2024.09.003_b0085","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.ygyno.2016.10.031","article-title":"Triaging HPV-positive women with p16\/Ki-67 dual-stained cytology: results from a sub-study nested into the ATHENA trial","volume":"144","author":"Wright","year":"2017","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.ejogrb.2024.09.003_b0090","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.ejogrb.2017.03.029","article-title":"A model to evaluate the costs and clinical effectiveness of human papilloma virus screening compared with annual papanicolaou cytology in Germany","volume":"212","author":"Petry","year":"2017","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"12","key":"10.1016\/j.ejogrb.2024.09.003_b0095","doi-asserted-by":"crossref","DOI":"10.1093\/jnci\/djv257","article-title":"p16\/Ki-67 dual stain cytology for detection of cervical precancer in HPV-positive women","volume":"107","author":"Wentzensen","year":"2015","journal-title":"J Natl Cancer Inst"},{"issue":"2","key":"10.1016\/j.ejogrb.2024.09.003_b0100","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1097\/LGT.0000000000000802","article-title":"Recommendations for use of p16\/Ki67 dual stain for management of individuals testing positive for human papillomavirus","volume":"28","author":"Clarke","year":"2024","journal-title":"J Low Genit Tract Dis"},{"key":"10.1016\/j.ejogrb.2024.09.003_b0105","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.ejogrb.2017.01.010","article-title":"The impact on women's health and the cervical cancer screening budget of primary HPV screening with dual-stain cytology triage in Belgium","volume":"212","author":"Tjalma","year":"2017","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"7","key":"10.1016\/j.ejogrb.2024.09.003_b0110","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1038\/modpathol.2017.16","article-title":"Evaluation of p16\/Ki-67 dual-stained cytology as triage test for high-risk human papillomavirus-positive women","volume":"30","author":"Ebisch","year":"2017","journal-title":"Mod Pathol"},{"issue":"8","key":"10.1016\/j.ejogrb.2024.09.003_b0115","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24087158","article-title":"Triaging HPV-positive cervical samples with p16 and Ki-67 dual stained cytology within an organized screening program-A prospective observational study from Western Norway","volume":"24","author":"Ovestad","year":"2023","journal-title":"Int J Mol Sci"},{"issue":"2","key":"10.1016\/j.ejogrb.2024.09.003_b0120","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1097\/LGT.0000000000000525","article-title":"2019 ASCCP risk-based management consensus guidelines for abnormal cervical cancer screening tests and cancer precursors","volume":"24","author":"Perkins","year":"2020","journal-title":"J Low Genit Tract Dis"},{"issue":"4","key":"10.1016\/j.ejogrb.2024.09.003_b0125","first-page":"285","article-title":"Consensus guidelines for the management of abnormal cervical cancer screening tests by the SPCPTGI","volume":"36","author":"Pedro","year":"2023","journal-title":"Acta Med Port"},{"issue":"10","key":"10.1016\/j.ejogrb.2024.09.003_b0130","doi-asserted-by":"crossref","first-page":"2361","DOI":"10.1002\/ijc.29290","article-title":"Triaging HPV-positive women with normal cytology by p16\/Ki-67 dual-stained cytology testing: baseline and longitudinal data","volume":"136","author":"Uijterwaal","year":"2015","journal-title":"Int J Cancer"},{"issue":"7","key":"10.1016\/j.ejogrb.2024.09.003_b0135","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1158\/1055-9965.EPI-21-1425","article-title":"Clinical performance of triage strategies for Hr-HPV-positive women; a longitudinal evaluation of cytology, p16\/K-67 dual stain cytology, and HPV16\/18 genotyping","volume":"31","author":"Stanczuk","year":"2022","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"1","key":"10.1016\/j.ejogrb.2024.09.003_b0140","doi-asserted-by":"crossref","DOI":"10.1002\/jmv.28414","article-title":"Impact of high-risk Human Papillomavirus genotyping in cervical disease in the Northern region of Portugal: real-world data from regional cervical cancer screening program","volume":"95","author":"Rosario","year":"2023","journal-title":"J Med Virol"},{"issue":"1","key":"10.1016\/j.ejogrb.2024.09.003_b0145","doi-asserted-by":"crossref","first-page":"3679","DOI":"10.1038\/s41467-024-47909-x","article-title":"Concomitant human papillomavirus (HPV) vaccination and screening for elimination of HPV and cervical cancer","volume":"15","author":"Arroyo Muhr","year":"2024","journal-title":"Nat Commun"}],"container-title":["European Journal of Obstetrics & Gynecology and Reproductive Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211524004883?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211524004883?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,15]],"date-time":"2025-03-15T05:32:36Z","timestamp":1742016756000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301211524004883"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":29,"alternative-id":["S0301211524004883"],"URL":"https:\/\/doi.org\/10.1016\/j.ejogrb.2024.09.003","relation":{},"ISSN":["0301-2115"],"issn-type":[{"value":"0301-2115","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Optimization of HPV-positive women triage with p16\/Ki67 dual staining cytology in an organized cervical cancer screening program in the center region of Portugal","name":"articletitle","label":"Article Title"},{"value":"European Journal of Obstetrics & Gynecology and Reproductive Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejogrb.2024.09.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}