{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T11:07:06Z","timestamp":1789643226772,"version":"4.0.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"vor","delay-in-days":304,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejog.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Obstetrics &amp; Gynecology and Reproductive Biology"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.ejogrb.2025.02.025","type":"journal-article","created":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T03:02:42Z","timestamp":1739502162000},"page":"230-235","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["sCEACAM-1 levels in maternal blood in case of threatened preterm birth"],"prefix":"10.1016","volume":"307","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-4621-4850","authenticated-orcid":false,"given":"Bora","family":"Zaimi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Victoria","family":"Bazzano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian","family":"Rauh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Emilia","family":"Solano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurice","family":"Kappelmeyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"K\u00f6ninger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejogrb.2025.02.025_b0005","first-page":"264349","article-title":"Does the use of gestation-specific centiles for cervical length change the management of pregnancies at risk of recurrent spontaneous preterm birth?","author":"O'Reilly","year":"2021","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.ejogrb.2025.02.025_b0010","unstructured":"World Health Organization. Preterm birth [Internet]. 2023. Available from: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/preterm-birth."},{"key":"10.1016\/j.ejogrb.2025.02.025_b0015","article-title":"The global burden of disease attributable to preterm birth and low birth weight in 204 countries and territories from 1990 to 2019: an analysis of the Global Burden of Disease Study","volume":"2024","author":"Liu","year":"1990","journal-title":"J Glob Health"},{"issue":"1","key":"10.1016\/j.ejogrb.2025.02.025_b0020","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1186\/s12884-022-04552-y","article-title":"The role of maternal age on the risk of preterm birth among singletons and multiples: a retrospective cohort study in Lombardy, Norther Italy","volume":"22","author":"Esposito","year":"2022","journal-title":"BMC Pregnancy Childbirth"},{"issue":"1","key":"10.1016\/j.ejogrb.2025.02.025_b0025","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1097\/01.aoa.0000344666.82463.8d","article-title":"Preterm birth 1: epidemiology and causes of preterm birth","volume":"29","author":"Goldenberg","year":"2009","journal-title":"Obstet Anesth Dig"},{"key":"10.1016\/j.ejogrb.2025.02.025_b0030","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/8367571","article-title":"Prediction of preterm birth: maternal characteristics, ultrasound markers, and biomarkers: an updated overview","author":"Oskovi Kaplan","year":"2018","journal-title":"J Pregnancy"},{"issue":"20","key":"10.1016\/j.ejogrb.2025.02.025_b0035","doi-asserted-by":"crossref","first-page":"3445","DOI":"10.1080\/14767058.2019.1685962","article-title":"Placental alpha microglobulin-1 (PartoSure) test for the prediction of preterm birth: a systematic review and meta-analysis","volume":"34","author":"Pirjani","year":"2021","journal-title":"J Matern Fetal Neonatal Med"},{"key":"10.1016\/j.ejogrb.2025.02.025_b0040","first-page":"53599","article-title":"CEACAM1 specifically suppresses B cell receptor signaling-mediated activation","author":"Tsugawa","year":"2021","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.ejogrb.2025.02.025_b0045","first-page":"1412","article-title":"CEACAMS 1, 5, and 6 in disease and cancer: interactions with pathogens","author":"Thomas","year":"2023","journal-title":"Genes Cancer"},{"issue":"7","key":"10.1016\/j.ejogrb.2025.02.025_b0050","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1172\/JCI0215643","article-title":"Pivotal role of CEACAM1 protein in the inhibition of activated decidual lymphocyte functions","volume":"110","author":"Markel","year":"2002","journal-title":"J Clin Invest"},{"issue":"1","key":"10.1016\/j.ejogrb.2025.02.025_b0055","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/s43856-024-00525-8","article-title":"High-dimensional mapping of human CEACAM1 expression on immune cells and association with melanoma drug resistance","volume":"4","author":"Huang","year":"2024","journal-title":"Commun Med (Lond)"},{"key":"10.1016\/j.ejogrb.2025.02.025_b0060","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1295232","article-title":"The role of carcinoembryonic antigen-related cell adhesion molecule 1 in cancer","author":"G\u00f6tz","year":"2023","journal-title":"Front Immunol"},{"issue":"1","key":"10.1016\/j.ejogrb.2025.02.025_b0065","doi-asserted-by":"crossref","DOI":"10.1080\/09537104.2024.2308635","article-title":"Antiplatelet effects of the CEACAM1-derived peptide QDTT","volume":"35","author":"Ye","year":"2024","journal-title":"Platelets"},{"issue":"6","key":"10.1016\/j.ejogrb.2025.02.025_b0070","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/nri1864","article-title":"CEACAM1: contact-dependent control of immunity","volume":"6","author":"Gray-Owen","year":"2006","journal-title":"Nat Rev Immunol"},{"issue":"10","key":"10.1016\/j.ejogrb.2025.02.025_b0075","doi-asserted-by":"crossref","first-page":"5139","DOI":"10.4049\/jimmunol.168.10.5139","article-title":"Carcinoembryonic antigen-related cell adhesion molecule 1 expression and signaling in human, mouse, and rat leukocytes: evidence for replacement of the short cytoplasmic domain isoform by glycosylphosphatidylinositol-linked proteins in human leukocytes","volume":"168","author":"Singer","year":"2002","journal-title":"J Immunol"},{"issue":"3\u20134","key":"10.1016\/j.ejogrb.2025.02.025_b0080","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1007\/s10555-013-9444-6","article-title":"Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) in cancer progression and metastasis","volume":"32","author":"Beauchemin","year":"2013","journal-title":"Cancer Metastasis Rev"},{"issue":"8","key":"10.1016\/j.ejogrb.2025.02.025_b0085","doi-asserted-by":"crossref","first-page":"2138","DOI":"10.1002\/eji.200425021","article-title":"Biological function of the soluble CEACAM1 protein and implications in TAP2-deficient patients","volume":"34","author":"Markel","year":"2004","journal-title":"Eur J Immunol"},{"issue":"3","key":"10.1016\/j.ejogrb.2025.02.025_b0090","doi-asserted-by":"crossref","DOI":"10.3390\/cancers11030356","article-title":"Size matters: the functional role of the CEACAM1 isoform signature and its impact for NK cell-mediated killing in melanoma","volume":"11","author":"Helfrich","year":"2019","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.ejogrb.2025.02.025_b0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.smim.2019.101296","article-title":"Blumberg RS. CEACAM1 structure and function in immunity and its therapeutic implications","author":"Kim","year":"2019","journal-title":"Semin Immunol"},{"key":"10.1016\/j.ejogrb.2025.02.025_b0100","doi-asserted-by":"crossref","unstructured":"Yu J, Cai W, Zhou T, Men B, Chen S, Tu D, Guo W, Wang J, Zhao F, Wang Y. CEACAM1 increased the lymphangiogenesis through miR-423-5p and NF- kB in Non-Small Cell Lung Cancer. Biochem Biophys Rep. 2024;40101833. doi:10.1016\/j.bbrep.2024.101833 Cited in: PubMed; PMID 39398537.","DOI":"10.1016\/j.bbrep.2024.101833"},{"issue":"1","key":"10.1016\/j.ejogrb.2025.02.025_b0105","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1038\/s41467-018-04832-2","article-title":"CEACAM1 promotes CD8+ T cell responses and improves control of a chronic viral infection","volume":"9","author":"Khairnar","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.ejogrb.2025.02.025_b0110","doi-asserted-by":"crossref","unstructured":"Matsumoto H, Fujita Y, Onizawa M, Saito K, Sumichika Y, Yoshida S, Temmoku J, Matsuoka N, Yashiro-Furuya M, Asano T, Sato S, Suzuki E, Machida T, Watanabe H, Migita K. Increased CEACAM1 expression on peripheral blood neutrophils in patients with rheumatoid arthritis. Front Immunol. 2022;13978435. doi:10.3389\/fimmu.2022.978435 Cited in: PubMed; PMID 36591283.","DOI":"10.3389\/fimmu.2022.978435"},{"key":"10.1016\/j.ejogrb.2025.02.025_b0115","doi-asserted-by":"crossref","unstructured":"Horst AK, Najjar SM, Wagener C, Tiegs G. CEACAM1 in Liver Injury, Metabolic and Immune Regulation. Int J Mol Sci. 2018;19(10). doi:10.3390\/ijms19103110 Cited in: PubMed; PMID 30314283.","DOI":"10.3390\/ijms19103110"},{"key":"10.1016\/j.ejogrb.2025.02.025_b0120","doi-asserted-by":"crossref","unstructured":"Mach P, Gellhaus A, Prager S, Moore T, Wennemuth G, Kimmig R, K\u00f6ninger A, Singer BB. Soluble CEACAM1 and CEACAM6 are differently expressed in blood serum of pregnant women during normal pregnancy. Am J Reprod Immunol. 2017;78(4). doi:10.1111\/aji.12700 Cited in: PubMed; PMID 28593707.","DOI":"10.1111\/aji.12700"},{"key":"10.1016\/j.ejogrb.2025.02.025_b0125","article-title":"The maternal immune system during pregnancy and its influence on fetal development","volume":"171","author":"Morelli","year":"2015","journal-title":"RRBS"},{"key":"10.1016\/j.ejogrb.2025.02.025_b0130","doi-asserted-by":"crossref","unstructured":"Chatterjee P, Chiasson VL, Bounds KR, Mitchell BM. Regulation of the Anti-inflammatory cytokines interleukin-4 and interleukin-10 during pregnancy. Front Immunol. 2014;5253. doi:10.3389\/fimmu.2014.00253 Cited in: PubMed; PMID 24904596.","DOI":"10.3389\/fimmu.2014.00253"},{"issue":"2 Suppl 2","key":"10.1016\/j.ejogrb.2025.02.025_b0135","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.jaci.2009.12.980","article-title":"Overview of the immune response","volume":"125","author":"Chaplin","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.ejogrb.2025.02.025_b0140","unstructured":"Wegorzewska M. Maternal immune recognition of the semi-allogeneic fetus during fetal intervention in mice [Internet]: UCSF. 2014. Available from: https:\/\/escholarship.org\/uc\/item\/6k2754w1#main."},{"issue":"4","key":"10.1016\/j.ejogrb.2025.02.025_b0145","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1038\/ni.3131","article-title":"Immune mechanisms at the maternal-fetal interface: perspectives and challenges","volume":"16","author":"PrabhuDas","year":"2015","journal-title":"Nat Immunol"},{"issue":"7418","key":"10.1016\/j.ejogrb.2025.02.025_b0150","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/nature11462","article-title":"Pregnancy imprints regulatory memory that sustains anergy to fetal antigen","volume":"490","author":"Rowe","year":"2012","journal-title":"Nature"},{"issue":"10","key":"10.1016\/j.ejogrb.2025.02.025_b0155","doi-asserted-by":"crossref","first-page":"2858","DOI":"10.1002\/eji.201445404","article-title":"Progesterone promotes maternal-fetal tolerance by reducing human maternal T-cell polyfunctionality and inducing a specific cytokine profile","volume":"45","author":"Lissauer","year":"2015","journal-title":"Eur J Immunol"},{"issue":"1","key":"10.1016\/j.ejogrb.2025.02.025_b0160","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1111\/j.1749-6632.2010.05938.x","article-title":"Inflammation and pregnancy: the role of the immune system at the implantation site","volume":"1221","author":"Mor","year":"2011","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.ejogrb.2025.02.025_b0165","unstructured":"Mor G. Pregnancy Reconceived: What keeps a mother\u2019s immune system from treating her baby as foreign tissue? A new theory resolves the paradox. [Internet]. 2007. Available from: https:\/\/www.researchgate.net\/profile\/Gil-Mor-2\/publication\/291468070_Pregnancy_reconceived\/links\/56f54eea08ae95e8b6d1d51c\/Pregnancy-reconceived.pdf."},{"issue":"5\u20136","key":"10.1016\/j.ejogrb.2025.02.025_b0170","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1080\/10408360701548468","article-title":"Reproductive corticotropin releasing hormone, implantation, and fetal immunotolerance","volume":"44","author":"Kalantaridou","year":"2007","journal-title":"Crit Rev Clin Lab Sci"},{"key":"10.1016\/j.ejogrb.2025.02.025_b0175","doi-asserted-by":"crossref","unstructured":"Meakin C, Barrett ES, Aleksunes LM. Extravillous trophoblast migration and invasion: Impact of environmental chemicals and pharmaceuticals. Reprod Toxicol. 2022;10760\u20138. doi:10.1016\/j.reprotox.2021.11.008 Cited in: PubMed; PMID 34838982.","DOI":"10.1016\/j.reprotox.2021.11.008"},{"issue":"1","key":"10.1016\/j.ejogrb.2025.02.025_b0180","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1186\/s12967-019-1894-3","article-title":"Interferon gamma induces inflammatory responses through the interaction of CEACAM1 and PI3K in airway epithelial cells","volume":"17","author":"Zhu","year":"2019","journal-title":"J Transl Med"},{"key":"10.1016\/j.ejogrb.2025.02.025_b0185","first-page":"1)","article-title":"Osteopontin (OPN) is colocalized with the adhesion molecule CEACAM1 in the utero-placental system and enhances with its receptor Integrin \u00df3 the invasion of extravillous trophoblast cells","volume":"114(S","author":"Briese","year":"2006","journal-title":"Exp Clin Endocrinol Diabetes"},{"issue":"2","key":"10.1016\/j.ejogrb.2025.02.025_b0190","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1097\/01.pgp.0000189243.49522.ae","article-title":"Expression pattern of osteopontin in endometrial carcinoma: correlation with expression of the adhesion molecule CEACAM1","volume":"25","author":"Briese","year":"2006","journal-title":"Int J Gynecol Pathol"},{"key":"10.1016\/j.ejogrb.2025.02.025_b0195","doi-asserted-by":"crossref","unstructured":"Menon R, Richardson LS, Lappas M. Fetal membrane architecture, aging and inflammation in pregnancy and parturition. Placenta. 2019;7940\u20135. doi:10.1016\/j.placenta.2018.11.003. Cited in: PubMed; PMID 30454905.","DOI":"10.1016\/j.placenta.2018.11.003"},{"issue":"26","key":"10.1016\/j.ejogrb.2025.02.025_b0200","doi-asserted-by":"crossref","first-page":"3721","DOI":"10.1038\/sj.onc.1211033","article-title":"The CEACAM1-mediated apoptosis pathway is activated by CEA and triggers dual cleavage of CEACAM1","volume":"27","author":"Nittka","year":"2008","journal-title":"Oncogene"},{"issue":"58","key":"10.1016\/j.ejogrb.2025.02.025_b0205","doi-asserted-by":"crossref","first-page":"9306","DOI":"10.1038\/sj.onc.1208259","article-title":"The human tumor suppressor CEACAM1 modulates apoptosis and is implicated in early colorectal tumorigenesis","volume":"23","author":"Nittka","year":"2004","journal-title":"Oncogene"},{"issue":"10","key":"10.1016\/j.ejogrb.2025.02.025_b0210","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.placenta.2013.06.306","article-title":"Identification of biomarkers for preterm delivery in mid-trimester amniotic fluid","volume":"34","author":"Kim","year":"2013","journal-title":"Placenta"},{"issue":"2","key":"10.1016\/j.ejogrb.2025.02.025_b0215","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S1097-2765(00)80426-8","article-title":"CEA-related cell adhesion molecule 1: a potent angiogenic factor and a major effector of vascular endothelial growth factor","volume":"5","author":"Erg\u00fcn","year":"2000","journal-title":"Mol Cell"},{"key":"10.1016\/j.ejogrb.2025.02.025_b0220","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.18203\/2320-1770.ijrcog20150723","article-title":"Vaginal infections and its relation to preterm labour, PPROM, PROM and its outcome","author":"Shivaraju","year":"2015","journal-title":"Int J Reprod Contracept Obstet Gynecol"}],"container-title":["European Journal of Obstetrics &amp; Gynecology and Reproductive Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211525000922?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211525000922?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T07:16:22Z","timestamp":1769843782000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301211525000922"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":44,"alternative-id":["S0301211525000922"],"URL":"https:\/\/doi.org\/10.1016\/j.ejogrb.2025.02.025","relation":{},"ISSN":["0301-2115"],"issn-type":[{"value":"0301-2115","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"sCEACAM-1 levels in maternal blood in case of threatened preterm birth","name":"articletitle","label":"Article Title"},{"value":"European Journal of Obstetrics & Gynecology and Reproductive Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejogrb.2025.02.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}