{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T01:14:34Z","timestamp":1794014074062,"version":"4.8.0"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejog.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Obstetrics &amp; Gynecology and Reproductive Biology"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.ejogrb.2025.03.038","type":"journal-article","created":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T23:37:33Z","timestamp":1742859453000},"page":"150-157","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["The impact of serum homocysteine levels in women and men on pregnancy outcomes in fresh IVF\/ICSI cycles: A retrospective cohort study"],"prefix":"10.1016","volume":"309","author":[{"given":"Xuxin","family":"Zhan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingwei","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Lou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianguo","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejun","family":"Shang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejogrb.2025.03.038_b0005","doi-asserted-by":"crossref","DOI":"10.3390\/nu15173730","article-title":"Impact of Homocysteine as a Preconceptional Screening Factor for In Vitro Fertilization and Prevention of Miscarriage with Folic Acid Supplementation Following Frozen-Thawed Embryo Transfer: A Hospital-Based Retrospective Cohort Study","volume":"15","author":"Ogawa","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.ejogrb.2025.03.038_b0010","doi-asserted-by":"crossref","DOI":"10.3390\/biom13071111","article-title":"Homocysteine: Biochemistry, Molecular Biology, and Role in Disease 2021","volume":"13","author":"Sitdikova","year":"2023","journal-title":"Biomolecules"},{"key":"10.1016\/j.ejogrb.2025.03.038_b0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1590\/S0100-879X2009007500021","article-title":"Genetics of homocysteine metabolism and associated disorders","volume":"43","author":"Brustolin","year":"2010","journal-title":"Braz J Med Biol Res"},{"key":"10.1016\/j.ejogrb.2025.03.038_b0020","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21207698","article-title":"Homocysteine and Mitochondria in Cardiovascular and Cerebrovascular Systems","volume":"21","author":"Kaplan","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.ejogrb.2025.03.038_b0025","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/6652231","article-title":"A Novel Review of Homocysteine and Pregnancy Complications","volume":"2021","author":"Dai","year":"2021","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.ejogrb.2025.03.038_b0030","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.rbmo.2021.04.009","article-title":"Association of homocysteine with IVF\/ICSI outcomes stratified by MTHFR C677T polymorphisms: a prospective cohort study","volume":"43","author":"Chen","year":"2021","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.ejogrb.2025.03.038_b0035","article-title":"Association between serum homocysteine level and unexplained infertility in in vitro fertilization\/intracytoplasmic sperm injection (IVF\/ICSI): A retrospective, hospital-based, case-control study","volume":"34","author":"Liu","year":"2020","journal-title":"J Clin Lab Anal"},{"key":"10.1016\/j.ejogrb.2025.03.038_b0040","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/j.rbmo.2014.01.017","article-title":"Folic acid supplementation and IVF pregnancy outcome in women with unexplained infertility","volume":"28","author":"Murto","year":"2014","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.ejogrb.2025.03.038_b0045","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.reprotox.2017.12.003","article-title":"Homocysteine pathway and in vitro fertilization outcome","volume":"76","author":"Paffoni","year":"2018","journal-title":"Reprod Toxicol"},{"key":"10.1016\/j.ejogrb.2025.03.038_b0050","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1016\/0140-6736(92)90725-I","article-title":"Hyperhomocysteinaemia and recurrent spontaneous abortion or abruptio placentae","volume":"339","author":"Steegers-Theunissen","year":"1992","journal-title":"Lancet"},{"key":"10.1016\/j.ejogrb.2025.03.038_b0055","article-title":"Vitamin supplements and the risk for congenital anomalies other than neural tube defects","volume":"125c:12\u201321","author":"Botto","year":"2004","journal-title":"Am J Med Genet C Semin Med Genet"},{"key":"10.1016\/j.ejogrb.2025.03.038_b0060","first-page":"421","article-title":"Optimal serum and red blood cell folate concentrations in women of reproductive age for prevention of neural tube defects: World Health Organization guidelines","volume":"64","author":"Cordero","year":"2015","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"10.1016\/j.ejogrb.2025.03.038_b0065","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1016\/S0140-6736(06)68651-0","article-title":"Effect of B vitamins and genetics on success of in-vitro fertilisation: prospective cohort study","volume":"367","author":"Haggarty","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.ejogrb.2025.03.038_b0070","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1093\/ije\/dyp167","article-title":"Vasculopathic and thrombophilic risk factors for spontaneous preterm birth","volume":"38","author":"Kramer","year":"2009","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.ejogrb.2025.03.038_b0075","doi-asserted-by":"crossref","first-page":"520","DOI":"10.3109\/01443615.2012.693984","article-title":"Homocysteine, folate and pregnancy outcomes","volume":"32","author":"Kim","year":"2012","journal-title":"J Obstet Gynaecol"},{"key":"10.1016\/j.ejogrb.2025.03.038_b0080","doi-asserted-by":"crossref","first-page":"113","DOI":"10.4103\/aam.aam_41_19","article-title":"Association between maternal serum homocysteine concentrations in early pregnancy and adverse pregnancy outcomes","volume":"19","author":"Nwogu","year":"2020","journal-title":"Ann Afr Med"},{"key":"10.1016\/j.ejogrb.2025.03.038_b0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2024.111241","article-title":"Effects of hyperhomocysteinemia on follicular development and oocytes quality","volume":"27","author":"Wang","year":"2024","journal-title":"iScience"},{"key":"10.1016\/j.ejogrb.2025.03.038_b0090","doi-asserted-by":"crossref","DOI":"10.3389\/frph.2022.886277","article-title":"Homocysteine Level Related to Age Is Associated With Embryo Quality in Women Who Had IVF With Diminished Ovarian Reserve","volume":"4","author":"Wang","year":"2022","journal-title":"Front Reprod Health"},{"key":"10.1016\/j.ejogrb.2025.03.038_b0095","article-title":"Association between early spontaneous abortion and homocysteine metabolism","volume":"11","author":"Lei","year":"2024","journal-title":"Front Med (Lausanne)"},{"key":"10.1016\/j.ejogrb.2025.03.038_b0100","article-title":"The association between Vitamin D deficiency and clinical pregnancy rate in IVF patients with different age","volume":"15","author":"Wang","year":"2024","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.ejogrb.2025.03.038_b0105","doi-asserted-by":"crossref","DOI":"10.1080\/09513590.2024.2352133","article-title":"Comparison of the pregnancy outcomes of progestin-primed vs. antagonist ovarian stimulation in patients with poor ovarian response: a retrospective study","volume":"40","author":"Shi","year":"2024","journal-title":"Gynecol Endocrinol"},{"key":"10.1016\/j.ejogrb.2025.03.038_b0110","first-page":"2244","article-title":"Oocyte matched follicular fluid anti-M\u00fcllerian hormone is an excellent predictor of live birth after fresh single embryo transfer","volume":"34","author":"Ciepiela","year":"2019","journal-title":"Hum Reprod"},{"key":"10.1016\/j.ejogrb.2025.03.038_b0115","doi-asserted-by":"crossref","first-page":"521","DOI":"10.2164\/jandrol.106.001982","article-title":"Seminal plasma cobalamin significantly correlates with sperm concentration in men undergoing IVF or ICSI procedures","volume":"28","author":"Boxmeer","year":"2007","journal-title":"J Androl"},{"key":"10.1016\/j.ejogrb.2025.03.038_b0120","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.fertnstert.2010.08.054","article-title":"Polymorphisms in MTHFR and MTRR genes associated with blood plasma homocysteine concentration and sperm counts","volume":"95","author":"Montjean","year":"2011","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ejogrb.2025.03.038_b0125","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1007\/BF02867406","article-title":"Seminal plasma levels of 15-F2\u03b1-isoprostane, malondialdehyde and total homocysteine in normozoospermic and asthenozoospermic males","volume":"20","author":"Zarghami","year":"2005","journal-title":"Indian J Clin Biochem"}],"container-title":["European Journal of Obstetrics &amp; Gynecology and Reproductive Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211525001769?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211525001769?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T19:43:12Z","timestamp":1762285392000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301211525001769"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":25,"alternative-id":["S0301211525001769"],"URL":"https:\/\/doi.org\/10.1016\/j.ejogrb.2025.03.038","relation":{},"ISSN":["0301-2115"],"issn-type":[{"value":"0301-2115","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The impact of serum homocysteine levels in women and men on pregnancy outcomes in fresh IVF\/ICSI cycles: A retrospective cohort study","name":"articletitle","label":"Article Title"},{"value":"European Journal of Obstetrics & Gynecology and Reproductive Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejogrb.2025.03.038","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}