{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T07:44:43Z","timestamp":1790063083027,"version":"4.0.1"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejog.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Obstetrics & Gynecology and Reproductive Biology"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.ejogrb.2025.114067","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T19:39:09Z","timestamp":1747683549000},"page":"114067","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Risk factors for procedural interventions for retained products, after failed treatment with misoprostol or mifepristone and misoprostol for first trimester pregnancy loss \u2013 A retrospective cohort study"],"prefix":"10.1016","volume":"311","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7733-5026","authenticated-orcid":false,"given":"Nadav","family":"Cohen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hagit Itzhak","family":"Kedem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Coral","family":"Levy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ofer","family":"Lavie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariel","family":"Zilberlicht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejogrb.2025.114067_b0005","article-title":"Role of maternal age and pregnancy history in risk of miscarriage: prospective register based study","volume":"364","author":"Magnus","year":"2019","journal-title":"BMJ"},{"key":"10.1016\/j.ejogrb.2025.114067_b0010","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1056\/NEJMoa044064","article-title":"A comparison of medical management with misoprostol and surgical management for early pregnancy failure","volume":"353","author":"Zhang","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ejogrb.2025.114067_b0015","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1056\/NEJMoa1715726","article-title":"Mifepristone pretreatment for the medical management of early pregnancy loss","volume":"378","author":"Schreiber","year":"2018","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ejogrb.2025.114067_b0020","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/S0140-6736(20)31788-8","article-title":"Mifepristone and misoprostol versus misoprostol alone for the management of missed miscarriage (MifeMiso): a randomised, double-blind, placebo-controlled trial","volume":"396","author":"Chu","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.ejogrb.2025.114067_b0025","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/j.fertnstert.2006.03.032","article-title":"A randomized prospective study of misoprostol or mifepristone followed by misoprostol when needed for the treatment of women with early pregnancy failure","volume":"86","author":"Stockheim","year":"2006","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ejogrb.2025.114067_b0030","doi-asserted-by":"crossref","unstructured":"American College of Obstetricians and Gynecologists\u2019 Committee on Practice Bulletins\u2014Gynecology. ACOG practice bulletin no. 200: early pregnancy loss. Obstet Gynecol 2018; 132: e197\u2013e207.","DOI":"10.1097\/AOG.0000000000002899"},{"key":"10.1016\/j.ejogrb.2025.114067_b0035","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.fertnstert.2014.11.016","article-title":"Intrauterine adhesions after hysteroscopic treatment for retained products of conception: what are the risk factors?","volume":"103","author":"Barel","year":"2015","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ejogrb.2025.114067_b0040","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1111\/ajo.13455","article-title":"Hysteroscopic management of retained products of conception: A systematic review","volume":"62","author":"Taylor","year":"2022","journal-title":"Aust N Z J Obstet Gynaecol"},{"key":"10.1016\/j.ejogrb.2025.114067_b0045","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1111\/aogs.14229","article-title":"Diagnostic criteria for retained products of conception-A scoping review","volume":"100","author":"Hamel","year":"2021","journal-title":"Acta Obstet Gynecol Scand"},{"key":"10.1016\/j.ejogrb.2025.114067_b0050","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.ejogrb.2013.11.020","article-title":"Hysteroscopic management of retained products of conception: meta-analysis and literature review","volume":"173","author":"Smorgick","year":"2014","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.ejogrb.2025.114067_b0055","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1177\/0284185119855185","article-title":"Ultrasound criteria for managing postpartum patients with suspicion of retention of conception products","volume":"61","author":"Levinsohn-Tavor","year":"2020","journal-title":"Acta Radiol"},{"key":"10.1016\/j.ejogrb.2025.114067_b0060","doi-asserted-by":"crossref","first-page":"579","DOI":"10.7863\/jum.2009.28.5.579","article-title":"Sonographic appearances of the endometrium after termination of pregnancy in asymptomatic versus symptomatic women","volume":"28","author":"McEwing","year":"2009","journal-title":"J Ultrasound Med"},{"key":"10.1016\/j.ejogrb.2025.114067_b0065","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1002\/ijgo.13696","article-title":"Postpartum retained products of conception: Is it possible to avoid postpartum curettage?","volume":"156","author":"Nir","year":"2022","journal-title":"Int J Gynaecol Obstet"},{"key":"10.1016\/j.ejogrb.2025.114067_b0070","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1056\/NEJMra1302417","article-title":"Diagnostic criteria for nonviable pregnancy early in the first trimester","volume":"369","author":"Doubilet","year":"2013","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ejogrb.2025.114067_b0075","doi-asserted-by":"crossref","first-page":"357","DOI":"10.7863\/jum.2008.27.3.357","article-title":"Occurrence and outcome of residual trophoblastic tissue: a prospective study","volume":"27","author":"van den Bosch","year":"2008","journal-title":"J Ultrasound Med"},{"issue":"551","key":"10.1016\/j.ejogrb.2025.114067_b0080","doi-asserted-by":"crossref","first-page":"551.e1","DOI":"10.1016\/j.ajog.2020.04.006","article-title":"Management of early pregnancy loss with mifepristone and misoprostol: clinical predictors of treatment success from a randomized trial","volume":"223","author":"Sonalkar","year":"2020","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ejogrb.2025.114067_b0085","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1093\/humrep\/deac048","article-title":"Predicting the likelihood of successful medical treatment of early pregnancy loss: development and internal validation of a clinical prediction model","volume":"37","author":"Hamel","year":"2022","journal-title":"Hum Reprod"},{"issue":"599","key":"10.1016\/j.ejogrb.2025.114067_b0090","article-title":"Expectant vs medical management for retained products of conception after medical termination of pregnancy: a randomized controlled study","volume":"227","author":"Tzur","year":"2022","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ejogrb.2025.114067_b0095","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/j.jogc.2020.01.020","article-title":"Is hysteroscopy the best surgical approach for removal of retained products of conception following surgical termination of pregnancy?","volume":"42","author":"Smorgick","year":"2020","journal-title":"J Obstet Gynaecol Can"},{"key":"10.1016\/j.ejogrb.2025.114067_b0100","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s00404-021-06291-5","article-title":"Bleeding pattern after medical management of early pregnancy loss with mifepristone-misoprostol and its prognostic value: a prospective observational cohort study","volume":"306","author":"Enzelsberger","year":"2022","journal-title":"Arch Gynecol Obstet"},{"key":"10.1016\/j.ejogrb.2025.114067_b0105","first-page":"225","article-title":"Placenta percreta presenting in the first trimester and resulting in severe consumption coagulopathy and hysterectomy: a case report","volume":"35","author":"Papadakis","year":"2008","journal-title":"Clin Exp Obstet Gynecol"},{"key":"10.1016\/j.ejogrb.2025.114067_b0110","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1023\/A:1006701600323","article-title":"Pilot study on the use of repeated doses of misoprostol in termination of pregnancy at less than 9 weeks of gestation","volume":"15","author":"Tang","year":"1999","journal-title":"Adv Contracept"},{"key":"10.1016\/j.ejogrb.2025.114067_b0115","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1046\/j.1471-0528.2003.02225.x","article-title":"A viable alternative to surgical vacuum aspiration: repeated doses of intravaginal misoprostol over 9 hours for medical termination of pregnancies up to eight weeks","volume":"110","author":"Singh","year":"2003","journal-title":"BJOG"},{"key":"10.1016\/j.ejogrb.2025.114067_b0120","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.contraception.2004.04.002","article-title":"Comparative study between single dose 600 microg and repeated dose of oral misoprostol for treatment of incomplete abortion","volume":"70","author":"Phupong","year":"2004","journal-title":"Contraception"},{"key":"10.1016\/j.ejogrb.2025.114067_b0125","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.gmit.2017.05.002","article-title":"Hysteroscopic removal of retained products of conception following first trimester medical abortion","volume":"6","author":"Smorgick","year":"2017","journal-title":"Gynecol Minim Invasive Ther"},{"key":"10.1016\/j.ejogrb.2025.114067_b0130","doi-asserted-by":"crossref","first-page":"203","DOI":"10.4103\/GMIT.GMIT_125_20","article-title":"Hysteroscopy and retained products of conception: an update","volume":"10","author":"Foreste","year":"2021","journal-title":"Gynecol Minim Invasive Ther"},{"key":"10.1016\/j.ejogrb.2025.114067_b0135","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.jmig.2024.05.005","article-title":"Feasibility of office-based operative hysteroscopy by a tissue removal system without anesthesia","volume":"31","author":"Mor","year":"2024","journal-title":"J Minim Invasive Gynecol"},{"key":"10.1016\/j.ejogrb.2025.114067_b0140","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejogrb.2021.02.028","article-title":"Expectant management of retained products of conception following abortion: A retrospective cohort study","volume":"260","author":"Wada","year":"2021","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.ejogrb.2025.114067_b0145","doi-asserted-by":"crossref","first-page":"145","DOI":"10.7326\/M22-2568","article-title":"Short-term adverse outcomes after mifepristone-misoprostol versus procedural induced abortion\u00a0: A population-based propensity-weighted study","volume":"176","author":"Liu","year":"2023","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.ejogrb.2025.114067_b0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.jogc.2024.102604","article-title":"The success of mifepristone and misoprostol in the management of early pregnancy loss at a community hospital: A prospective study","volume":"46","author":"Farooqi","year":"2024","journal-title":"J Obstet Gynaecol Can"},{"key":"10.1016\/j.ejogrb.2025.114067_b0155","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1097\/AOG.0000000000004063","article-title":"Mifepristone combination therapy compared with misoprostol monotherapy for the management of miscarriage: A cost-effectiveness analysis","volume":"136","author":"Berkley","year":"2020","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ejogrb.2025.114067_b0160","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1111\/1471-0528.16737","article-title":"Cost-effectiveness of mifepristone and misoprostol versus misoprostol alone for the management of missed miscarriage: an economic evaluation based on the MifeMiso trial","volume":"128","author":"Okeke Ogwulu","year":"2021","journal-title":"BJOG"}],"container-title":["European Journal of Obstetrics & Gynecology and Reproductive Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211525003434?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211525003434?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T03:45:56Z","timestamp":1774928756000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301211525003434"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":32,"alternative-id":["S0301211525003434"],"URL":"https:\/\/doi.org\/10.1016\/j.ejogrb.2025.114067","relation":{},"ISSN":["0301-2115"],"issn-type":[{"value":"0301-2115","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Risk factors for procedural interventions for retained products, after failed treatment with misoprostol or mifepristone and misoprostol for first trimester pregnancy loss \u2013 A retrospective cohort study","name":"articletitle","label":"Article Title"},{"value":"European Journal of Obstetrics & Gynecology and Reproductive Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejogrb.2025.114067","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"114067"}}