{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:45:22Z","timestamp":1790887522428,"version":"4.1.0"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejog.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Obstetrics & Gynecology and Reproductive Biology"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.ejogrb.2025.114669","type":"journal-article","created":{"date-parts":[[2025,8,24]],"date-time":"2025-08-24T21:50:38Z","timestamp":1756072238000},"page":"114669","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["MMP2\/TIMP2 ratio as a measurable indicator for differentiating diffuse adenomyosis, ovarian endometriosis, and their co-existence"],"prefix":"10.1016","volume":"314","author":[{"given":"Imon","family":"Mitra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bishnupriya","family":"Saha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subhash Chandra","family":"Halder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunita","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pratip","family":"Chakraborty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8739-5110","authenticated-orcid":false,"given":"Koel","family":"Chaudhury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejogrb.2025.114669_b0005","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/j.fertnstert.2023.03.006","article-title":"Endometriosis and adenomyosis: shared pathophysiology","volume":"119","author":"Bulun","year":"2023","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ejogrb.2025.114669_b0010","doi-asserted-by":"crossref","unstructured":"Buggio L, Dridi D, Barbara G. Adenomyosis: Impact on fertility and obstetric outcomes. Reprod Biol 2021;28:3081-3084.https:\/\/doi.org\/10.1007\/s43032-021-00679-z\/Published.","DOI":"10.1007\/s43032-021-00679-z"},{"key":"10.1016\/j.ejogrb.2025.114669_b0015","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.fertnstert.2023.03.018","article-title":"Association of endometriosis and adenomyosis with pregnancy and infertility","volume":"119","author":"Vercellini","year":"2023","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ejogrb.2025.114669_b0020","doi-asserted-by":"crossref","DOI":"10.1002\/rmb2.12473","article-title":"Increased risk of obstetric complications in patients with adenomyosis: a narrative literature review","volume":"21","author":"Harada","year":"2022","journal-title":"Reprod Med Biol"},{"key":"10.1016\/j.ejogrb.2025.114669_b0025","first-page":"3123","article-title":"The bimodal role of matrix metalloproteinases and their inhibitors in etiology and pathogenesis of endometriosis (Review)","volume":"18","author":"Balkowiec","year":"2018","journal-title":"Mol Med Rep"},{"key":"10.1016\/j.ejogrb.2025.114669_b0030","doi-asserted-by":"crossref","first-page":"779","DOI":"10.3390\/diagnostics12040779","article-title":"Impaired expression of membrane type-2 and type-3 matrix metalloproteinases in endometriosis but not in adenomyosis","volume":"12","author":"Maoga","year":"2022","journal-title":"Diagnostics (Basel)"},{"key":"10.1016\/j.ejogrb.2025.114669_b0035","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.3390\/biom11111739","article-title":"The role of matrix metalloproteinases in endometriosis: a potential target","volume":"11","author":"Ke","year":"2021","journal-title":"Biomolecules"},{"key":"10.1016\/j.ejogrb.2025.114669_b0040","doi-asserted-by":"crossref","first-page":"177","DOI":"10.3109\/14756366.2016.1161620","article-title":"Matrix metalloproteinases (MMPs), the main extracellular matrix (ECM) enzymes in collagen degradation, as a target for anticancer drugs","volume":"31","author":"Jab\u0142o\u0144ska-Trypu\u0107","year":"2016","journal-title":"J Enzyme Inhib Med Chem"},{"key":"10.1016\/j.ejogrb.2025.114669_b0045","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1515\/med-2018-0037","article-title":"MMP-2 and TIMP-2 in patients with heart failure and chronic kidney disease","volume":"13","author":"Kobusiak-Prokopowicz","year":"2018","journal-title":"Open Med"},{"key":"10.1016\/j.ejogrb.2025.114669_b0050","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.734485","article-title":"The imbalance of MMP-2\/TIMP-2 and MMP-9\/TIMP-1 contributes to collagen deposition disorder in diabetic non-injured skin","volume":"12","author":"Zhou","year":"2021","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.ejogrb.2025.114669_b0055","doi-asserted-by":"crossref","first-page":"395","DOI":"10.18632\/oncotarget.26571","article-title":"Matrix metalloproteinase 2 (MMP-2) and its tissue inhibitor 2 (TIMP-2) in pancreatic cancer","volume":"10","author":"\u0141ukaszewicz-Zaj\u0105c","year":"2019","journal-title":"Oncotarget"},{"key":"10.1016\/j.ejogrb.2025.114669_b0060","doi-asserted-by":"crossref","unstructured":"Azevedo Martins JM, Rabelo-Santos SH, Do Amaral Westin MC, Zeferino LC. Tumoral and stromal expression of MMP-2, MMP-9, MMP-14, TIMP-1, TIMP-2, and VEGF-A in cervical cancer patient survival: A competing risk analysis. BMC Cancer 2020;20:660. https:\/\/doi.org\/10.1186\/s12885-020-07150-3.","DOI":"10.1186\/s12885-020-07150-3"},{"key":"10.1016\/j.ejogrb.2025.114669_b0065","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1159\/000094426","article-title":"Matrix metalloproteinase-2 and -9 expression correlated with angiogenesis in human adenomyosis","volume":"62","author":"Li","year":"2006","journal-title":"Gynecol Obstet Invest"},{"key":"10.1016\/j.ejogrb.2025.114669_b0070","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1016\/j.fertnstert.2008.05.090","article-title":"Increased matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-1 secretion but unaffected invasiveness of endometrial stromal cells in adenomyosis","volume":"91","author":"Yang","year":"2009","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ejogrb.2025.114669_b0075","doi-asserted-by":"crossref","first-page":"314","DOI":"10.25122\/jml-2020-0117","article-title":"Expression and significance of matrix metalloproteinase-2 and matrix metalloproteinas-9 in endometriosis","volume":"13","author":"Barbe","year":"2020","journal-title":"J Med Life"},{"key":"10.1016\/j.ejogrb.2025.114669_b0080","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/S0015-0282(02)03322-8","article-title":"Matrix metalloproteinase-2, membranous type 1 matrix metalloproteinase, and tissue inhibitor of metalloproteinase-2 expression in ectopic and eutopic endometrium","volume":"78","author":"Chung","year":"2002","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ejogrb.2025.114669_b0085","doi-asserted-by":"crossref","first-page":"2840","DOI":"10.3390\/ijms21082840","article-title":"Expression of matrix metalloproteinases and their inhibitors in endometrium: High levels in endometriotic lesions","volume":"21","author":"Luddi","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.ejogrb.2025.114669_b0090","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0163540","article-title":"Regulation of matrix metalloproteinase-2 activity by COX-2-PGE2-pAKT axis promotes angiogenesis in endometriosis","volume":"11","author":"Jana","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.ejogrb.2025.114669_b0095","doi-asserted-by":"crossref","first-page":"111","DOI":"10.11648\/j.jgo.20150306.12","article-title":"The balance of matrix metalloproteinase-2 (Mmp-2) and tissue inhibitor of matrix metalloproteinase-2 (Timp-2) on severe endometriosis","volume":"3","author":"Rambulangi","year":"2015","journal-title":"J Gynecol Obstetr"},{"key":"10.1016\/j.ejogrb.2025.114669_b0100","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1002\/uog.14806","article-title":"Terms, definitions and measurements to describe sonographic features of myometrium and uterine masses: a consensus opinion from the Morphological Uterus Sonographic Assessment (MUSA) group","volume":"46","author":"Van Den Bosch","year":"2015","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.ejogrb.2025.114669_b0105","doi-asserted-by":"crossref","first-page":"e2981","DOI":"10.6061\/clinics\/2021\/e2981","article-title":"Association of 2D and 3D transvaginal ultrasound findings with adenomyosis in symptomatic women of reproductive age: a prospective study","volume":"76","author":"Marques","year":"2021","journal-title":"Clinics"},{"key":"10.1016\/j.ejogrb.2025.114669_b0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.lansea.2025.100547","article-title":"Endometriosis and adenomyosis research priorities in India and Sri Lanka: a call for regional collaboration","volume":"34","author":"Munshi","year":"2025","journal-title":"Lancet Regional Health - Southeast Asia"},{"key":"10.1016\/j.ejogrb.2025.114669_b0115","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s00428-004-1117-y","article-title":"Eutopic endometrium and peritoneal, ovarian and bowel endometriotic tissues express a different profile of matrix metalloproteinases-2, -3 and -11, and of tissue inhibitor metalloproteinases-1 and -2","volume":"445","author":"Uzan","year":"2004","journal-title":"Virchows Arch"},{"key":"10.1016\/j.ejogrb.2025.114669_b0120","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1093\/humrep\/deh290","article-title":"Evidence for an increased release of proteolytic activity by the eutopic endometrial tissue in women with endometriosis and for involvement of matrix metalloproteinase-9","volume":"19","author":"Collette","year":"2004","journal-title":"Hum Reprod"},{"key":"10.1016\/j.ejogrb.2025.114669_b0125","doi-asserted-by":"crossref","first-page":"2701","DOI":"10.1016\/j.fertnstert.2009.11.024","article-title":"Mechanisms regulating invasiveness and growth of endometriosis lesions in rat experimental model and in humans","volume":"93","author":"Sotnikova","year":"2010","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ejogrb.2025.114669_b0130","doi-asserted-by":"crossref","first-page":"114","DOI":"10.36838\/v6i5.18","article-title":"The Ratio of MMP-2 to TIMP-2 as probable prognostic biomarker in Indian cancer patients","volume":"6","author":"Balajiv","year":"2024","journal-title":"Int J High School Res"},{"key":"10.1016\/j.ejogrb.2025.114669_b0135","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1477-7827-11-2","article-title":"Circulating matrix metalloproteinase MMP-9 and MMP-2\/TIMP-2 complex are associated with spontaneous early pregnancy failure","volume":"11","author":"Nissi","year":"2013","journal-title":"Reprod Biol Endocrinol"},{"key":"10.1016\/j.ejogrb.2025.114669_b0140","doi-asserted-by":"crossref","first-page":"20052","DOI":"10.1038\/s41598-021-99577-2","article-title":"MMPs and TIMPs levels are correlated with anthropometric parameters, blood pressure, and endothelial function in obesity","volume":"11","author":"Boumiza","year":"2021","journal-title":"Sci Rep"}],"container-title":["European Journal of Obstetrics & Gynecology and Reproductive Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211525009455?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211525009455?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T19:43:29Z","timestamp":1762285409000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301211525009455"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":28,"alternative-id":["S0301211525009455"],"URL":"https:\/\/doi.org\/10.1016\/j.ejogrb.2025.114669","relation":{},"ISSN":["0301-2115"],"issn-type":[{"value":"0301-2115","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MMP2\/TIMP2 ratio as a measurable indicator for differentiating diffuse adenomyosis, ovarian endometriosis, and their co-existence","name":"articletitle","label":"Article Title"},{"value":"European Journal of Obstetrics & Gynecology and Reproductive Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejogrb.2025.114669","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"114669"}}