{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T01:22:08Z","timestamp":1788916928113,"version":"build-2803163510"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T00:00:00Z","timestamp":1758067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejog.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Obstetrics & Gynecology and Reproductive Biology"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.ejogrb.2025.114729","type":"journal-article","created":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T06:58:24Z","timestamp":1758697104000},"page":"114729","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Serum relaxin levels and cardiovascular health in pregnancy: A secondary analysis of the Oxfordshire women and their Children\u2019s health (OxWATCH) study"],"prefix":"10.1016","volume":"315","author":[{"given":"Rachel","family":"Altman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Dragovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Southcombe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Granne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6809-6107","authenticated-orcid":false,"given":"Pedro","family":"Melo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejogrb.2025.114729_b0005","article-title":"Pre-eclampsia: pathophysiology and clinical implications","volume":"366","author":"Burton","year":"2019","journal-title":"BMJ"},{"key":"10.1016\/j.ejogrb.2025.114729_b0010","doi-asserted-by":"crossref","unstructured":"Dimitriadis, E., Rolnik, D. L., Zhou, W., Estrada-Gutierrez, G., Koga, K., Francisco, R. P. V., Whitehead, C., Hyett, J., Costa, F. D., Nicolaides, K., & Menkhorst, E. (2023). Pre-eclampsia. Nature Reviews Disease Primers, 9(1). doi:ARTN 8 10.1038\/s41572-023-00417-6.","DOI":"10.1038\/s41572-023-00417-6"},{"issue":"18","key":"10.1016\/j.ejogrb.2025.114729_b0015","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22189972","article-title":"Luteinizing hormone regulation of inter-organelle communication and fate of the corpus luteum","volume":"22","author":"Przygrodzka","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"4","key":"10.1016\/j.ejogrb.2025.114729_b0020","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1093\/humupd\/dmab003","article-title":"Secretory products of the corpus luteum and preeclampsia","volume":"27","author":"Pereira","year":"2021","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.ejogrb.2025.114729_b0025","doi-asserted-by":"crossref","first-page":"104","DOI":"10.3389\/fmed.2020.00104","article-title":"Increased risk of pre-eclampsia after frozen-thawed embryo transfer in programming cycles","volume":"7","author":"Wang","year":"2020","journal-title":"Front Med"},{"issue":"1","key":"10.1016\/j.ejogrb.2025.114729_b0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ajogmf.2022.100752","article-title":"Programmed frozen embryo transfer cycle increased risk of hypertensive disorders of pregnancy: a multicenter cohort study in ovulatory women","volume":"5","author":"Gu","year":"2023","journal-title":"Am J Obstet Gynecol Mfm"},{"issue":"6","key":"10.1016\/j.ejogrb.2025.114729_b0035","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1016\/j.rbmo.2021.03.002","article-title":"Lower risk of adverse perinatal outcomes in natural versus artificial frozen-thawed embryo transfer cycles: a systematic review and meta-analysis","volume":"42","author":"Moreno-Sepulveda","year":"2021","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.ejogrb.2025.114729_b0040","doi-asserted-by":"crossref","unstructured":"Zong, L. P., Liu, P. H., Zhou, L. G., Wei, D. M., Ding, L. L., & Qin, Y. Y. (2020). Increased risk of maternal and neonatal complications in hormone replacement therapy cycles in frozen embryo transfer. Reproductive Biology and Endocrinology, 18(1). doi:ARTN 36 10.1186\/s12958-020-00601-3.","DOI":"10.1186\/s12958-020-00601-3"},{"issue":"3","key":"10.1016\/j.ejogrb.2025.114729_b0045","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1161\/HYPERTENSIONAHA.119.13015","article-title":"Maternal cardiovascular dysregulation during early pregnancy after in vitro fertilization cycles in the absence of a corpus luteum","volume":"74","author":"Conrad","year":"2019","journal-title":"Hypertension"},{"issue":"2","key":"10.1016\/j.ejogrb.2025.114729_b0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajog.2019.03.010","article-title":"Neonatal and maternal outcome after frozen embryo transfer: increased risks in programmed cycles","volume":"221","author":"Ginstrom Ernstad","year":"2019","journal-title":"Am J Obstet Gynecol"},{"issue":"3","key":"10.1016\/j.ejogrb.2025.114729_b0055","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1177\/1933719116657189","article-title":"The role of relaxin in normal and abnormal uterine function during the menstrual cycle and early pregnancy","volume":"24","author":"Marshall","year":"2017","journal-title":"Reprod Sci"},{"issue":"3","key":"10.1016\/j.ejogrb.2025.114729_b0060","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1007\/s11897-013-0148-6","article-title":"Relaxin for treatment of acute heart failure: making the case for treating targeted patient profiles","volume":"10","author":"Hernandez-Montfort","year":"2013","journal-title":"Curr Heart Fail Rep"},{"issue":"10","key":"10.1016\/j.ejogrb.2025.114729_b0065","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1111\/bph.13614","article-title":"Vascular actions of relaxin: nitric oxide and beyond","volume":"174","author":"Leo","year":"2017","journal-title":"Br J Pharmacol"},{"issue":"4","key":"10.1016\/j.ejogrb.2025.114729_b0070","doi-asserted-by":"crossref","first-page":"E677","DOI":"10.1152\/ajpendo.00225.2019","article-title":"Potential influence of the corpus luteum on circulating reproductive and volume regulatory hormones, angiogenic and immunoregulatory factors in pregnant women","volume":"317","author":"Conrad","year":"2019","journal-title":"Am J Phys Endocrinol Metab"},{"issue":"4","key":"10.1016\/j.ejogrb.2025.114729_b0075","doi-asserted-by":"crossref","first-page":"251","DOI":"10.3109\/00016349509024444","article-title":"Variations in serum relaxin (Hrlx-2) concentrations during human-pregnancy","volume":"74","author":"Petersen","year":"1995","journal-title":"Acta Obstet Gynecol Scand"},{"key":"10.1016\/j.ejogrb.2025.114729_b0080","first-page":"47","article-title":"Circulating pregnancy hormone relaxin as a first trimester biomarker for preeclampsia","volume":"22","author":"Uiterweer","year":"2020","journal-title":"Preg Hypert Int J Womens Cardiovascular Health"},{"issue":"5","key":"10.1016\/j.ejogrb.2025.114729_b0085","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.ajog.2021.08.018","article-title":"Potential role of the corpus luteum in maternal cardiovascular adaptation to pregnancy and preeclampsia risk","volume":"226","author":"Conrad","year":"2022","journal-title":"Am J Obstet Gynecol"},{"issue":"11","key":"10.1016\/j.ejogrb.2025.114729_b0090","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2015-009282","article-title":"Oxfordshire Women and their Children's Health (OxWATCH): protocol for a prospective cohort feasibility study","volume":"5","author":"Harrison","year":"2015","journal-title":"BMJ Open"},{"issue":"6","key":"10.1016\/j.ejogrb.2025.114729_b0095","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1161\/HYP.0000000000000066","volume":"71","author":"Whelton","year":"2018","journal-title":"Hypertension"},{"issue":"4","key":"10.1016\/j.ejogrb.2025.114729_b0100","first-page":"585","article-title":"Relaxin in human-pregnancy serum measured with an homologous radioimmunoassay","volume":"69","author":"Bell","year":"1987","journal-title":"Obstet Gynecol"},{"issue":"8501","key":"10.1016\/j.ejogrb.2025.114729_b0105","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0140-6736(86)92068-4","article-title":"Serum relaxin in pregnancy","volume":"2","author":"Maclennan","year":"1986","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.ejogrb.2025.114729_b0110","first-page":"167","article-title":"Relaxin in normal and pathogenic pregnancies","volume":"59","author":"Szlachter","year":"1982","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ejogrb.2025.114729_b0115","first-page":"124","article-title":"Relaxin-2 connecting peptide (pro-RLX2) levels in second trimester serum samples to predict preeclampsia","volume":"11","author":"Rehfeldt","year":"2018","journal-title":"Preg Hypert Int J Womens Cardiovasc Health"},{"key":"10.1016\/j.ejogrb.2025.114729_b0120","article-title":"Serum relaxin in preeclamptic and normotensive pregnant women at the Lagos University Teaching Hospital","volume":"21","author":"Ugwu","year":"2022","journal-title":"Hellenic J Obstet Gynecol"},{"issue":"1","key":"10.1016\/j.ejogrb.2025.114729_b0125","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1093\/humrep\/16.1.13","article-title":"Reproductive hormones and blood pressure during pregnancy","volume":"16","author":"Kristiansson","year":"2001","journal-title":"Hum Reprod"},{"issue":"3","key":"10.1016\/j.ejogrb.2025.114729_b0130","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1161\/HYPERTENSIONAHA.118.12046","article-title":"Absent or excessive corpus luteum number is associated with altered maternal vascular health in early pregnancy","volume":"73","author":"von Versen-Hoynck","year":"2019","journal-title":"Hypertension"},{"issue":"12","key":"10.1016\/j.ejogrb.2025.114729_b0135","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1038\/jhh.2017.61","article-title":"Placental growth factor and pre-eclampsia","volume":"31","author":"Chau","year":"2017","journal-title":"J Hum Hypertens"},{"issue":"6","key":"10.1016\/j.ejogrb.2025.114729_b0140","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.1161\/HYPERTENSIONAHA.120.15830","article-title":"Angiogenic factors and long-term cardiovascular risk in women that developed preeclampsia during pregnancy","volume":"76","author":"Garrido-Gimenez","year":"2020","journal-title":"Hypertension"}],"container-title":["European Journal of Obstetrics & Gynecology and Reproductive Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030121152501005X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030121152501005X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T03:38:50Z","timestamp":1765337930000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S030121152501005X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":28,"alternative-id":["S030121152501005X"],"URL":"https:\/\/doi.org\/10.1016\/j.ejogrb.2025.114729","relation":{},"ISSN":["0301-2115"],"issn-type":[{"value":"0301-2115","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Serum relaxin levels and cardiovascular health in pregnancy: A secondary analysis of the Oxfordshire women and their Children\u2019s health (OxWATCH) study","name":"articletitle","label":"Article Title"},{"value":"European Journal of Obstetrics & Gynecology and Reproductive Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejogrb.2025.114729","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"114729"}}