{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T03:41:18Z","timestamp":1765338078184,"version":"3.46.0"},"reference-count":21,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejog.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Obstetrics &amp; Gynecology and Reproductive Biology"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.ejogrb.2025.114754","type":"journal-article","created":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T15:15:47Z","timestamp":1759504547000},"page":"114754","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Biostimulation with polynucleotide cream during adjuvant therapy for breast cancer"],"prefix":"10.1016","volume":"315","author":[{"given":"Giada","family":"Lavitola","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginia","family":"Foreste","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0125-075X","authenticated-orcid":false,"given":"Danilo","family":"Borrelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia Di","family":"Filippo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Corace","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Bifulco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejogrb.2025.114754_b0005","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.maturitas.2014.07.013","article-title":"Genitourinary syndrome of menopause: new terminology for vulvovaginal atrophy from the International Society for the Study of Women\u2019s Sexual Health and the North American Menopause Society","volume":"79","author":"Portman","year":"2014","journal-title":"Maturitas"},{"key":"10.1016\/j.ejogrb.2025.114754_b0065","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1097\/GME.0000000000001609","article-title":"The 2020 genitourinary syndrome of menopause position statement of the North American Menopause Society","volume":"27","author":"Faubion","year":"2020","journal-title":"Menopause"},{"key":"10.1016\/j.ejogrb.2025.114754_b0010","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.maturitas.2015.09.001","article-title":"Vaginal atrophy of women in postmenopause. results from a multicentric observational study: the AGATA study","volume":"83","author":"Palma","year":"2016","journal-title":"Maturitas"},{"key":"10.1016\/j.ejogrb.2025.114754_b0015","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1097\/01.GME.0000117061.40493.AB","article-title":"Association of breast cancer and its therapy with menopause-related symptoms","volume":"11","author":"Crandall","year":"2004","journal-title":"Menopause"},{"key":"10.1016\/j.ejogrb.2025.114754_b0020","doi-asserted-by":"crossref","first-page":"36","DOI":"10.3109\/13697137.2011.647840","article-title":"Vaginal health: insights, views & attitudes (VIVA)\u2014results from an international survey","volume":"15","author":"Nappi","year":"2012","journal-title":"Climacteric"},{"key":"10.1016\/j.ejogrb.2025.114754_b0025","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1111\/jsm.12190","article-title":"Vulvar and vaginal atrophy in postmenopausal women: findings from the REVIVE (REal Women\u2019s views of Treatment Options for Menopausal Vaginal ChangEs) survey","volume":"10","author":"Kingsberg","year":"2013","journal-title":"J Sex Med"},{"key":"10.1016\/j.ejogrb.2025.114754_b0030","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.jsxm.2017.01.010","article-title":"The Women\u2019s EMPOWER survey: identifying women\u2019s perceptions on vulvar and vaginal atrophy and its treatment","volume":"14","author":"Kingsberg","year":"2017","journal-title":"J Sex Med"},{"key":"10.1016\/j.ejogrb.2025.114754_b0035","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.ajog.2016.07.045","article-title":"Genitourinary syndrome of menopause: an overview of clinical manifestations, pathophysiology, etiology, evaluation, and management","volume":"215","author":"Gandhi","year":"2016","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ejogrb.2025.114754_b0040","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1097\/GRF.0000000000000126","article-title":"Vulvar and vaginal atrophy: physiology, clinical presentation, and treatment considerations","volume":"58","author":"Lev-Sagie","year":"2015","journal-title":"Clin Obstet Gynecol"},{"key":"10.1016\/j.ejogrb.2025.114754_b0045","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1002\/cncr.11126","article-title":"The biology of breast carcinoma","volume":"97","author":"Keen","year":"2003","journal-title":"Cancer"},{"key":"10.1016\/j.ejogrb.2025.114754_b0050","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1097\/00001813-200409000-00003","article-title":"Acute effects of tamoxifen and third-generation aromatase inhibitors on menopausal symptoms of breast cancer patients","volume":"15","author":"Morales","year":"2004","journal-title":"Anticancer Drugs"},{"key":"10.1016\/j.ejogrb.2025.114754_b0055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11912-016-0517-x","article-title":"Vaginal health during breast cancer treatment","volume":"18","author":"Falk","year":"2016","journal-title":"Curr Oncol Rep"},{"key":"10.1016\/j.ejogrb.2025.114754_b0060","doi-asserted-by":"crossref","first-page":"87","DOI":"10.4065\/mcp.2009.0413","article-title":"Vulvovaginal atrophy","volume":"85","author":"Bride","year":"2010","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.ejogrb.2025.114754_b0070","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.clbc.2015.06.005","article-title":"Genitourinary syndrome of menopause in breast cancer survivors: are we facing new and safe hopes?","volume":"15","author":"Biglia","year":"2015","journal-title":"Clin Breast Cancer"},{"issue":"1","key":"10.1016\/j.ejogrb.2025.114754_b0085","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.jsxm.2016.11.317","article-title":"Validation of clinical tools for vaginal and vulvar symptom assessment in cancer patients and survivors","volume":"14","author":"Eaton","year":"2017","journal-title":"J Sex Med"},{"key":"10.1016\/j.ejogrb.2025.114754_b0075","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1080\/009262300278597","article-title":"The Female Sexual Function Index (FSFI): a multidimensional self-report instrument for the assessment of female sexual function","volume":"26","author":"Rosen","year":"2000","journal-title":"J Sex Marital Ther"},{"issue":"1","key":"10.1016\/j.ejogrb.2025.114754_b0080","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/j.1464-410X.2006.05885.x","article-title":"Flow Study Group. Italian validation of the international consultation on incontinence questionnaires","volume":"97","author":"Tubaro","year":"2006","journal-title":"BJU Int"},{"key":"10.1016\/j.ejogrb.2025.114754_b0100","doi-asserted-by":"crossref","first-page":"770","DOI":"10.3390\/medicina58060770","article-title":"New innovations for the treatment of vulvovaginal atrophy: an up-to-date review","volume":"58","author":"Benini","year":"2022","journal-title":"Medicina (Kaunas)"},{"issue":"7","key":"10.1016\/j.ejogrb.2025.114754_b0105","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.3390\/cancers17071241","article-title":"CO2 laser therapy for genitourinary syndrome of menopause in women with breast cancer: a randomized, sham-controlled trial","volume":"17","author":"Jaber","year":"2025","journal-title":"Cancers (Basel)"},{"issue":"5","key":"10.1016\/j.ejogrb.2025.114754_b0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.jogoh.2025.102933","article-title":"Long-term efficacy of CO2fractional laser in the treatment of genitourinary syndrome of menopause","volume":"54","author":"Favier","year":"2025","journal-title":"J Gynecol Obstet Hum Reprod"},{"key":"10.1016\/j.ejogrb.2025.114754_b0110","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.ejogrb.2024.09.020","article-title":"Sexuality after breast cancer treatment: a physician's survey of current clinical practice","volume":"302","author":"Van Cauwenbergh","year":"2024","journal-title":"Eur J Obstet Gynecol Reprod Biol"}],"container-title":["European Journal of Obstetrics &amp; Gynecology and Reproductive Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211525010309?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211525010309?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T03:38:38Z","timestamp":1765337918000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301211525010309"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":21,"alternative-id":["S0301211525010309"],"URL":"https:\/\/doi.org\/10.1016\/j.ejogrb.2025.114754","relation":{},"ISSN":["0301-2115"],"issn-type":[{"type":"print","value":"0301-2115"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Biostimulation with polynucleotide cream during adjuvant therapy for breast cancer","name":"articletitle","label":"Article Title"},{"value":"European Journal of Obstetrics & Gynecology and Reproductive Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejogrb.2025.114754","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"114754"}}