{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T07:13:00Z","timestamp":1793085180832,"version":"4.5.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejog.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Obstetrics &amp; Gynecology and Reproductive Biology"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.ejogrb.2026.115228","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T23:57:58Z","timestamp":1780531078000},"page":"115228","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Lactobacillus-containing probiotics and clinical pregnancy in infertile women undergoing ART: a systematic review and meta-analysis"],"prefix":"10.1016","volume":"324","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7128-2859","authenticated-orcid":false,"given":"Daiki","family":"Hiratsuka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0241-9780","authenticated-orcid":false,"given":"Yasushi","family":"Hirota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.ejogrb.2026.115228_b0005","doi-asserted-by":"crossref","DOI":"10.1093\/hropen\/hoac051","article-title":"Infertility prevalence and the methods of estimation from 1990 to 2021: a systematic review and meta-analysis","volume":"2022","author":"Cox","year":"2022","journal-title":"Hum Reprod Open"},{"issue":"1","key":"10.1016\/j.ejogrb.2026.115228_b0010","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.rbmo.2013.08.011","article-title":"Recurrent implantation failure: definition and management","volume":"28","author":"Coughlan","year":"2014","journal-title":"Reprod Biomed"},{"issue":"1","key":"10.1016\/j.ejogrb.2026.115228_b0015","first-page":"16","article-title":"Non-invasive preimplantation genetic testing (niPGT): the next revolution in reproductive genetics?","volume":"26","author":"Leaver","year":"2020","journal-title":"Hum Reprod"},{"key":"10.1016\/j.ejogrb.2026.115228_b0020","article-title":"The effect of temporary uterine artery ligation on laparoscopic myomectomy to reduce intraoperative blood loss: a retrospective case-control study","volume":"15","author":"Hiratsuka","year":"2022","journal-title":"Eur J Obstet Gynecol Reprod Biol X"},{"issue":"3","key":"10.1016\/j.ejogrb.2026.115228_b0025","doi-asserted-by":"crossref","first-page":"174","DOI":"10.4103\/gmit.gmit_64_23","article-title":"Anesthesia-free in-office hysteroscopic morcellation for endometrial polyps: a prospective study","volume":"13","author":"Hiratsuka","year":"2024","journal-title":"Gynecol Minim Invasive Ther"},{"issue":"1","key":"10.1016\/j.ejogrb.2026.115228_b0030","doi-asserted-by":"crossref","DOI":"10.1111\/jog.16185","article-title":"Adenomyosis with uterine abscess formation treated by adenomyomectomy: a report of two cases","volume":"51","author":"Hiratsuka","year":"2025","journal-title":"J Obstet Gynaecol Res"},{"issue":"6","key":"10.1016\/j.ejogrb.2026.115228_b0035","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.ajog.2016.09.075","article-title":"Evidence that the endometrial microbiota has an effect on implantation success or failure","volume":"215","author":"Moreno","year":"2016","journal-title":"Am J Obstet Gynecol"},{"issue":"1","key":"10.1016\/j.ejogrb.2026.115228_b0040","doi-asserted-by":"crossref","first-page":"8272","DOI":"10.1038\/s41598-025-92906-9","article-title":"Comparison of diagnostic tests for chronic endometritis and endometrial dysbiosis in recurrent implantation failure: impact on pregnancy outcomes","volume":"15","author":"Hiratsuka","year":"2025","journal-title":"Sci Rep"},{"issue":"3","key":"10.1016\/j.ejogrb.2026.115228_b0045","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.tjog.2024.03.004","article-title":"The role of probiotics as adjunct treatment in the prevention and management of gynecological infections: an updated meta-analysis of 35 RCT studies","volume":"63","author":"Abavisani","year":"2024","journal-title":"Taiwan J Obstet Gynecol"},{"issue":"5","key":"10.1016\/j.ejogrb.2026.115228_b0050","doi-asserted-by":"crossref","first-page":"363","DOI":"10.18502\/ijrm.v22i5.16435","article-title":"Intravaginal probiotics before embryo transfer do not improve pregnancy rates in recurrent implantation failure cases: an RCT","volume":"22","author":"Naghi Jafarabadi","year":"2024","journal-title":"Int J Reprod Biomed"},{"issue":"4","key":"10.1016\/j.ejogrb.2026.115228_b0055","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1007\/s10815-024-03066-0","article-title":"Impact of vaginal microecological differences on pregnancy outcomes and endometrial microbiota in frozen embryo transfer cycles","volume":"41","author":"Wei","year":"2024","journal-title":"J Assist Reprod Genet"},{"issue":"5","key":"10.1016\/j.ejogrb.2026.115228_b0060","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1007\/s00404-023-07147-w","article-title":"The effect of normalizing vaginal microbiome using Lactovag in improving pregnancy outcomes in frozen embryo transfer cycles: a randomized clinical trial","volume":"308","author":"Tanha","year":"2023","journal-title":"Arch Gynecol Obstet"},{"issue":"1","key":"10.1016\/j.ejogrb.2026.115228_b0065","doi-asserted-by":"crossref","first-page":"11892","DOI":"10.1038\/s41598-023-39078-6","article-title":"Pregnancy outcomes after vaginal probiotic supplementation before frozen embryo transfer: a randomized controlled study","volume":"13","author":"Thanaboonyawat","year":"2023","journal-title":"Sci Rep"},{"issue":"11","key":"10.1016\/j.ejogrb.2026.115228_b0070","doi-asserted-by":"crossref","DOI":"10.3390\/nu17111860","article-title":"Ligilactobacillus salivarius CECT5713 increases term pregnancies in women with infertility of unknown origin: a randomized, triple-blind, placebo-controlled trial","volume":"17","author":"Huerga L\u00f3pez","year":"2025","journal-title":"Nutrients"},{"issue":"3","key":"10.1016\/j.ejogrb.2026.115228_b0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.humimm.2025.111259","article-title":"The effect of vitamin D supplementation and vaginal probiotics on fertility in women with recurrent implantation failure: a randomized clinical trial","volume":"86","author":"Badihi","year":"2025","journal-title":"Hum Immunol"},{"issue":"1","key":"10.1016\/j.ejogrb.2026.115228_b0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.humimm.2024.111220","article-title":"The role of probiotics in restoring the Th1 to Th2 ratio in women experiencing recurrent implantation failure; a double-blind randomized clinical trial","volume":"86","author":"Kamrani","year":"2025","journal-title":"Hum Immunol"},{"issue":"1","key":"10.1016\/j.ejogrb.2026.115228_b0085","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1186\/s12884-025-07338-0","article-title":"Vaginal probiotics as therapeutic adjuncts for improving embryo transfer success rates: a systematic review and meta-analysis","volume":"25","author":"Maleki-Hajiagha","year":"2025","journal-title":"BMC Pregn Childbirth"},{"issue":"1","key":"10.1016\/j.ejogrb.2026.115228_b0090","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1002\/rmb2.12250","article-title":"A pilot study and case reports on endometrial microbiota and pregnancy outcome: an analysis using 16S rRNA gene sequencing among IVF patients, and trial therapeutic intervention for dysbiotic endometrium","volume":"18","author":"Kyono","year":"2018","journal-title":"Reprod Med Biol"},{"issue":"1","key":"10.1016\/j.ejogrb.2026.115228_b0095","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s10815-022-02688-6","article-title":"Therapeutic intervention based on gene sequencing analysis of microbial 16S ribosomal RNA of the intrauterine microbiome improves pregnancy outcomes in IVF patients: a prospective cohort study","volume":"40","author":"Iwami","year":"2023","journal-title":"J Assist Reprod Genet"},{"issue":"3","key":"10.1016\/j.ejogrb.2026.115228_b0100","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.repbio.2020.07.001","article-title":"Use of a vaginal probiotic suppository and antibiotics to influence the composition of the endometrial microbiota","volume":"20","author":"Kadogami","year":"2020","journal-title":"Reprod Biol"},{"issue":"6","key":"10.1016\/j.ejogrb.2026.115228_b0105","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1016\/S0015-0282(00)01624-1","article-title":"Bacteria in the transfer catheter tip influence the live-birth rate after in vitro fertilization","volume":"74","author":"Moore","year":"2000","journal-title":"Fertil Steril"},{"issue":"3","key":"10.1016\/j.ejogrb.2026.115228_b0110","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0119793","article-title":"Detection and characterisation of Lactobacillus spp. in the bovine uterus and their influence on bovine endometrial epithelial cells in vitro","volume":"10","author":"G\u00e4rtner","year":"2015","journal-title":"PLoS One"},{"issue":"9","key":"10.1016\/j.ejogrb.2026.115228_b0115","doi-asserted-by":"crossref","DOI":"10.3390\/jcm11092481","article-title":"Endometrial dysbiosis is related to inflammatory factors in women with repeated implantation failure: a pilot study","volume":"11","author":"Cela","year":"2022","journal-title":"J Clin Med"},{"issue":"2","key":"10.1016\/j.ejogrb.2026.115228_b0120","doi-asserted-by":"crossref","first-page":"12","DOI":"10.3390\/ht9020012","article-title":"Microbiota and human reproduction: the case of female infertility","volume":"9","author":"Tomaiuolo","year":"2020","journal-title":"High Throughput"},{"issue":"4","key":"10.1016\/j.ejogrb.2026.115228_b0125","doi-asserted-by":"crossref","first-page":"525","DOI":"10.3390\/healthcare11040525","article-title":"Microbiota ecosystem in recurrent cystitis and the immunological microenvironment of urothelium","volume":"11","author":"Dominoni","year":"2023","journal-title":"Healthcare (Basel)"},{"issue":"1","key":"10.1016\/j.ejogrb.2026.115228_b0130","doi-asserted-by":"crossref","DOI":"10.1002\/rmb2.70040","article-title":"Endometrial Microbiome and Implantation: from basic knowledge to clinical medicine","volume":"25","author":"Hiratsuka","year":"2026","journal-title":"Reprod Med Biol"},{"issue":"1","key":"10.1016\/j.ejogrb.2026.115228_b0135","doi-asserted-by":"crossref","first-page":"e1671","DOI":"10.52225\/narra.v5i1.1671","article-title":"Effective probiotic regimens for bacterial vaginosis treatment and recurrence prevention: a systematic review","volume":"5","author":"Udjianto","year":"2025","journal-title":"Narra J"},{"issue":"1","key":"10.1016\/j.ejogrb.2026.115228_b0140","doi-asserted-by":"crossref","first-page":"4191","DOI":"10.1038\/s41467-021-24516-8","article-title":"Translocation of vaginal microbiota is involved in impairment and protection of uterine health","volume":"12","author":"Wang","year":"2021","journal-title":"Nat Commun"},{"issue":"2","key":"10.1016\/j.ejogrb.2026.115228_b0145","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0928-8244(02)00465-0","article-title":"Oral use of Lactobacillus rhamnosus GR-1 and L. fermentum RC-14 significantly alters vaginal flora: randomized, placebo-controlled trial in 64 healthy women","volume":"35","author":"Reid","year":"2003","journal-title":"FEMS Immunol Med Microbiol"},{"issue":"1","key":"10.1016\/j.ejogrb.2026.115228_b0150","doi-asserted-by":"crossref","first-page":"8467","DOI":"10.1038\/s41598-022-12095-7","article-title":"Endometrial microbiome: sampling, assessment, and possible impact on embryo implantation","volume":"12","author":"Reschini","year":"2022","journal-title":"Sci Rep"},{"issue":"12","key":"10.1016\/j.ejogrb.2026.115228_b0155","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.1007\/s10815-019-01630-7","article-title":"Does dysbiotic endometrium affect blastocyst implantation in IVF patients?","volume":"36","author":"Hashimoto","year":"2019","journal-title":"J Assist Reprod Genet"},{"issue":"1","key":"10.1016\/j.ejogrb.2026.115228_b0160","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40168-021-01184-w","article-title":"Endometrial microbiota composition is associated with reproductive outcome in infertile patients","volume":"10","author":"Moreno","year":"2022","journal-title":"Microbiome"},{"key":"10.1016\/j.ejogrb.2026.115228_b0165","doi-asserted-by":"crossref","unstructured":"Hiratsuka D, Matsuo M, Hirota Y. The Reproductive Tract Microbiome and Female Fertility: Dysbiosis, Disease Links, and Emerging Therapeutic Strategies. Fertil Steril. 2026; published online Jan 21. DOI: 10.1016\/j.fertnstert.2026.01.010 Online ahead of print.","DOI":"10.1016\/j.fertnstert.2026.01.010"},{"issue":"1","key":"10.1016\/j.ejogrb.2026.115228_b0170","doi-asserted-by":"crossref","first-page":"5166","DOI":"10.1038\/s41467-025-60205-6","article-title":"Efficacy of clindamycin and LACTIN-V for in vitro fertilization patients with vaginal dysbiosis: a randomised double-blind, placebo-controlled multicentre trial","volume":"16","author":"Haahr","year":"2025","journal-title":"Nat Commun"}],"container-title":["European Journal of Obstetrics &amp; Gynecology and Reproductive Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211526002964?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211526002964?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T20:31:18Z","timestamp":1783974678000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301211526002964"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":34,"alternative-id":["S0301211526002964"],"URL":"https:\/\/doi.org\/10.1016\/j.ejogrb.2026.115228","relation":{},"ISSN":["0301-2115"],"issn-type":[{"value":"0301-2115","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lactobacillus-containing probiotics and clinical pregnancy in infertile women undergoing ART: a systematic review and meta-analysis","name":"articletitle","label":"Article Title"},{"value":"European Journal of Obstetrics & Gynecology and Reproductive Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejogrb.2026.115228","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"115228"}}