{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T20:39:43Z","timestamp":1792528783634,"version":"4.5.0"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T00:00:00Z","timestamp":1783987200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014679","name":"Royal Scottish Geographical Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014679","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007344","name":"Achmea BV","doi-asserted-by":"publisher","award":["2021381"],"award-info":[{"award-number":["2021381"]}],"id":[{"id":"10.13039\/501100007344","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejog.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Obstetrics &amp; Gynecology and Reproductive Biology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.ejogrb.2026.115317","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T15:56:48Z","timestamp":1784044608000},"page":"115317","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["The association between oral antihypertensive agents and perinatal outcomes in early-onset fetal growth restriction: A post-hoc analysis of the Dutch OPTICORE study"],"prefix":"10.1016","volume":"325","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-7023-0274","authenticated-orcid":false,"given":"Rosalie J.","family":"Hup","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mette","family":"van de Meent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wessel","family":"Ganzevoort","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanne J.","family":"Gordijn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth M.W.","family":"Kooi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wes","family":"Onland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes J.","family":"Duvekot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eline","family":"van der Wilk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9 F.","family":"Kornelisse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salwan","family":"Al-Nasiry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reint","family":"Jellema","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. Marieke","family":"Knol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gwendolyn Tr.","family":"Manten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne M.","family":"Mulder-de Tollenaer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan B.","family":"Derks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Floris","family":"Groenendaal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mireille N.","family":"Bekker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewoud","family":"Schuit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martine","family":"Depmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Kooiman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Titia","family":"Lely","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"S1","key":"10.1016\/j.ejogrb.2026.115317_b0005","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/ijgo.13522","article-title":"FIGO (International Federation of Gynecology and Obstetrics) initiative on fetal growth: best practice advice for screening, diagnosis, and management of fetal growth restriction","volume":"152","author":"Melamed","year":"2021","journal-title":"Int J Gynecol Obstet"},{"issue":"2","key":"10.1016\/j.ejogrb.2026.115317_b0010","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1111\/aogs.13702","article-title":"Early\u2010onset fetal growth restriction: a systematic review on mortality and morbidity","volume":"99","author":"Pels","year":"2020","journal-title":"Acta Obstet Gynecol Scand"},{"issue":"4","key":"10.1016\/j.ejogrb.2026.115317_b0015","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1002\/uog.13190","article-title":"Perinatal morbidity and mortality in early\u2010onset fetal growth restriction: cohort outcomes of the trial of randomized umbilical and fetal flow in Europe (TRUFFLE)","volume":"42","author":"Lees","year":"2013","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"9983","key":"10.1016\/j.ejogrb.2026.115317_b0020","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.1016\/S0140-6736(14)62049-3","article-title":"2 year neurodevelopmental and intermediate perinatal outcomes in infants with very preterm fetal growth restriction (TRUFFLE): a randomised trial","volume":"385","author":"Lees","year":"2015","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.ejogrb.2026.115317_b0025","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1002\/uog.12537","article-title":"First-trimester screening for early and late small-for-gestational-age neonates using maternal serum biochemistry, blood pressure and uterine artery Doppler","volume":"43","author":"Crovetto","year":"2014","journal-title":"Ultrasound Obstetrics Gynecol"},{"issue":"2","key":"10.1016\/j.ejogrb.2026.115317_b0030","doi-asserted-by":"crossref","first-page":"S745","DOI":"10.1016\/j.ajog.2017.11.577","article-title":"Pathophysiology of placental-derived fetal growthrestriction","volume":"218","author":"Burton","year":"2018","journal-title":"Am J Obstet Gynecol"},{"issue":"1","key":"10.1016\/j.ejogrb.2026.115317_b0035","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.ogc.2019.10.008","article-title":"The placental basis of fetal growth restriction","volume":"47","author":"Zur","year":"2020","journal-title":"Obstet Gynecol Clin North Am"},{"issue":"6","key":"10.1016\/j.ejogrb.2026.115317_b0040","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2020.5323","article-title":"Maternal Sildenafil vs placebo in pregnant women with severe early-onset fetal growth restriction","volume":"3","author":"Pels","year":"2020","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.ejogrb.2026.115317_b0045","article-title":"Pre-eclampsia: pathophysiology and clinical implications","volume":"l2381","author":"Burton","year":"2019","journal-title":"BMJ"},{"issue":"4","key":"10.1016\/j.ejogrb.2026.115317_b0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajog.2015.08.003","article-title":"biomarkers, syncytiotrophoblast stress, and placental capacity","volume":"213","author":"Redman","year":"2015","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ejogrb.2026.115317_b0055","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.preghy.2018.05.004","article-title":"The hypertensive disorders of pregnancy: ISSHP classification, diagnosis & management recommendations for international practice","volume":"13","author":"Brown","year":"2018","journal-title":"Pregnancy Hypertens Elsevier BV"},{"issue":"2","key":"10.1016\/j.ejogrb.2026.115317_b0060","doi-asserted-by":"crossref","first-page":"S783","DOI":"10.1016\/j.ajog.2017.12.226","article-title":"Outcome in early-onset fetal growth restriction isbest combining computerized fetal heart rate analysis with ductus venosus Doppler: insights from the Trial of Umbilical and Fetal Flow in Europe","volume":"218","author":"Frusca","year":"2018","journal-title":"Am J Obstet Gynecol"},{"issue":"11","key":"10.1016\/j.ejogrb.2026.115317_b0065","doi-asserted-by":"crossref","first-page":"2122","DOI":"10.1111\/aogs.70049","article-title":"Impact of hypertensive disorders on disease progression in pregnancies affected by early\u2010onset fetal growth restriction","volume":"104","author":"Chmielewska","year":"2025","journal-title":"Acta Obstet Gynecol Scand"},{"issue":"1","key":"10.1016\/j.ejogrb.2026.115317_b0070","doi-asserted-by":"crossref","first-page":"e26","DOI":"10.1097\/AOG.0000000000003020","article-title":"Chronic hypertension in pregnancy: ACOG practice bulletin, number 203","volume":"133","author":"American College of Obstetricians and Gynecologists","year":"2019","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ejogrb.2026.115317_b0075","unstructured":"Nederlandse Vereniging voor Obstetrie en Gynaecologie (NVOG). Hypertensieve Aandoeningen in de Zwangerschap. 2014. Accessed March 11, 2025. https:\/\/richtlijnendatabase.nl\/richtlijn\/hypertensieve_aandoeningen_in_de_zwangerschap\/startpagina_-_hypertensieve_aandoeningen_in_de_zwangerschap.html."},{"key":"10.1016\/j.ejogrb.2026.115317_b0080","first-page":"17","article-title":"Maternal and neonatal outcomes of antihypertensive treatment in pregnancy: a retrospective cohort study","author":"Dublin","year":"2022","journal-title":"PLoS One"},{"issue":"7","key":"10.1016\/j.ejogrb.2026.115317_b0085","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1161\/HYPERTENSIONAHA.122.18920","article-title":"Role of antihypertensive treatment and blood pressure control in the occurrence of adverse pregnancy outcomes: a population-based study of linked electronic health records","volume":"79","author":"Al Khalaf","year":"2022","journal-title":"Hypertension"},{"issue":"1","key":"10.1016\/j.ejogrb.2026.115317_b0090","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1097\/AOG.0000000000005613","article-title":"Pregnancy outcomes of nifedipine compared with labetalol for oral treatment of mild chronic hypertension","volume":"144","author":"Sanusi","year":"2024","journal-title":"Obstet Gynecol"},{"issue":"3","key":"10.1016\/j.ejogrb.2026.115317_b0095","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2022-070729","article-title":"OPtimal TIming of antenatal COrticosteroid administration in pregnancies complicated by early-onset fetal growth REstriction (OPTICORE): study protocol of a multicentre, retrospective cohort study","volume":"13","author":"van de Meent","year":"2023","journal-title":"BMJ Open"},{"issue":"3","key":"10.1016\/j.ejogrb.2026.115317_b0100","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1002\/uog.15884","article-title":"Consensus definition of fetal growth restriction: a Delphi procedure","volume":"48","author":"Gordijn","year":"2016","journal-title":"Ultrasound in Obstet Gynecol"},{"issue":"4","key":"10.1016\/j.ejogrb.2026.115317_b0105","doi-asserted-by":"crossref","first-page":"383.e1","DOI":"10.1016\/j.ajog.2018.12.023","article-title":"From population reference to national standard: new and improved birthweight charts","volume":"220","author":"Hoftiezer","year":"2019","journal-title":"Am J Obstet Gynecol"},{"issue":"4","key":"10.1016\/j.ejogrb.2026.115317_b0110","doi-asserted-by":"crossref","first-page":"339.e1","DOI":"10.1016\/j.ajog.2019.05.039","article-title":"A core outcome set for the prevention and treatment of fetal GROwth restriction: deVeloping endpoints: the COSGROVE study","volume":"221","author":"Healy","year":"2019","journal-title":"Am J Obstet Gynecol"},{"issue":"9","key":"10.1016\/j.ejogrb.2026.115317_b0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.jacadv.2025.102054","article-title":"Comparative effectiveness and safety of labetalol versus nifedipine for treatment of chronic hypertension during pregnancy","volume":"4","author":"Leonard","year":"2025","journal-title":"JACC Adv"},{"issue":"7","key":"10.1016\/j.ejogrb.2026.115317_b0120","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1111\/1471-0528.13569","article-title":"Do labetalol and methyldopa have different effects on pregnancy outcome? Analysis of data from the Control of Hypertension In Pregnancy Study (CHIPS) trial","volume":"123","author":"Magee","year":"2016","journal-title":"BJOG"},{"issue":"15","key":"10.1016\/j.ejogrb.2026.115317_b0125","article-title":"The risk for neonatal hypoglycemia and bradycardia after beta-blocker use during pregnancy or lactation: a systematic review and meta-analysis","volume":"19","author":"de Bruin","year":"2022","journal-title":"Int J Environ Res Public Health MDPI"},{"issue":"6","key":"10.1016\/j.ejogrb.2026.115317_b0130","doi-asserted-by":"crossref","first-page":"e237","DOI":"10.1097\/AOG.0000000000003891","article-title":"Gestational hypertension and preeclampsia: ACOG practice bulletin, number 222","volume":"135","author":"American College of Obstetricians and Gynecologists","year":"2020","journal-title":"Obstet Gynecol"}],"container-title":["European Journal of Obstetrics &amp; Gynecology and Reproductive Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211526003854?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211526003854?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T20:04:21Z","timestamp":1792526661000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301211526003854"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":26,"alternative-id":["S0301211526003854"],"URL":"https:\/\/doi.org\/10.1016\/j.ejogrb.2026.115317","relation":{},"ISSN":["0301-2115"],"issn-type":[{"value":"0301-2115","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The association between oral antihypertensive agents and perinatal outcomes in early-onset fetal growth restriction: A post-hoc analysis of the Dutch OPTICORE study","name":"articletitle","label":"Article Title"},{"value":"European Journal of Obstetrics & Gynecology and Reproductive Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejogrb.2026.115317","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"115317"}}