{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T21:59:33Z","timestamp":1790200773523,"version":"4.1.0"},"reference-count":23,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejog.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Obstetrics & Gynecology and Reproductive Biology"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.ejogrb.2026.115448","type":"journal-article","created":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T23:30:48Z","timestamp":1789860648000},"page":"115448","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Improved overall survival with combined adjuvant chemotherapy and radiation in stage I uterine carcinosarcoma: A national cancer database study"],"prefix":"10.1016","volume":"327","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-1063-2688","authenticated-orcid":false,"given":"Andrew","family":"Polio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrienne","family":"Esposito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesus Gonzalez","family":"Bosquet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Goodheart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent M.","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejogrb.2026.115448_b0005","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.ygyno.2015.03.041","article-title":"Uterine carcinosarcoma: a review of the literature","volume":"137","author":"Cantrell","year":"2015","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.ejogrb.2026.115448_b0010","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1136\/ijgc-2022-004073","volume":"33","author":"Bogani","year":"2023","journal-title":"Int J Gynecol Cancer"},{"key":"10.1016\/j.ejogrb.2026.115448_b0015","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1056\/NEJMra1514010","article-title":"Endometrial cancer","volume":"383","author":"Lu","year":"2020","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ejogrb.2026.115448_b0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijgc.2025.101672","article-title":"Updates and controversies in the management of uterine serous carcinoma and uterine carcinosarcoma","volume":"35","author":"Toboni","year":"2025","journal-title":"Int J Gynecol Cancer"},{"key":"10.1016\/j.ejogrb.2026.115448_b0025","article-title":"Increasing incidence of uterine carcinosarcoma: a United States cancer statistics study","volume":"40","author":"Liao","year":"2022","journal-title":"Gynecol Oncol Rep"},{"key":"10.1016\/j.ejogrb.2026.115448_b0030","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.ygyno.2005.04.027","article-title":"Endometrial carcinosarcomas have a different prognosis and pattern of spread compared to high-risk epithelial endometrial cancer","volume":"98","author":"Amant","year":"2005","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.ejogrb.2026.115448_b0035","article-title":"Adjuvant radiotherapy and\/or chemotherapy after surgery for uterine carcinosarcoma","volume":"2018","author":"Galaal","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.ejogrb.2026.115448_b0040","article-title":"Patterns of adjuvant treatment and survival outcomes in stage I uterine carcinosarcoma","volume":"39","author":"Cory","year":"2022","journal-title":"Gynecol. Oncol. Rep."},{"key":"10.1016\/j.ejogrb.2026.115448_b0045","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.ygyno.2012.06.020","article-title":"A multi-institutional cohort study of adjuvant therapy in stage I-II uterine carcinosarcoma","volume":"127","author":"Cantrell","year":"2012","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.ejogrb.2026.115448_b0050","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.ygyno.2017.02.001","article-title":"Impact of adjuvant therapy on recurrence patterns in stage I uterine carcinosarcoma","volume":"145","author":"Matsuo","year":"2017","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.ejogrb.2026.115448_b0055","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.ygyno.2015.09.002","article-title":"A multi-institutional study of outcomes in stage I-III uterine carcinosarcoma","volume":"139","author":"Dickson","year":"2015","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.ejogrb.2026.115448_b0060","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.ygyno.2022.10.004","article-title":"Not all stage I and II endometrial cancers are created equal: recurrence-free survival and cause-specific survival after observation or vaginal brachytherapy alone in all subgroups of early-stage high-intermediate and high-risk endometrial cancer","volume":"167","author":"Garzon","year":"2022","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.ejogrb.2026.115448_b0065","doi-asserted-by":"crossref","first-page":"E11","DOI":"10.1016\/j.ijrobp.2020.02.488","article-title":"Adjuvant vaginal cuff brachytherapy and patterns of failure for early stage uterine carcinosarcoma","volume":"108","author":"Zhu","year":"2020","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ejogrb.2026.115448_b0070","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.ygyno.2017.01.010","article-title":"Stage I uterine carcinosarcoma: matched cohort analyses for lymphadenectomy, chemotherapy, and brachytherapy","volume":"145","author":"Seagle","year":"2017","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.ejogrb.2026.115448_b0075","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1097\/IGC.0000000000001014","article-title":"Use of adjuvant chemotherapy, radiation therapy, or combined modality therapy and the impact on survival for uterine carcinosarcoma limited to the pelvis","volume":"27","author":"Wong","year":"2017","journal-title":"Int J Gynecol Cancer"},{"key":"10.1016\/j.ejogrb.2026.115448_b0080","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1097\/COC.0000000000000360","article-title":"Chemoradiation versus chemotherapy in uterine carcinosarcoma: patterns of care and impact on overall survival","volume":"41","author":"Odei","year":"2018","journal-title":"Am J Clin Oncol"},{"key":"10.1016\/j.ejogrb.2026.115448_b0085","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.ygyno.2015.08.014","article-title":"Patterns of care, predictors and outcomes of chemotherapy for uterine carcinosarcoma: a national cancer database analysis","volume":"139","author":"Rauh-Hain","year":"2015","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.ejogrb.2026.115448_b0090","unstructured":"Guidelines Detail, NCCN (n.d.). https:\/\/www.nccn.org\/guidelines\/guidelines-detail?id\u00a0=\u00a01473 (accessed June 8, 2025)."},{"key":"10.1016\/j.ejogrb.2026.115448_b0095","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.ygyno.2018.10.034","article-title":"Prognostic factors impacting survival in early stage uterine carcinosarcoma","volume":"152","author":"Kurnit","year":"2019","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.ejogrb.2026.115448_b0100","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1097\/IGC.0000000000000561","article-title":"The impact of adjuvant therapy on survival and recurrence patterns in women with early-stage uterine carcinosarcoma: a multi-institutional study","volume":"26","author":"Guttmann","year":"2016","journal-title":"Int J Gynecol Cancer"},{"key":"10.1016\/j.ejogrb.2026.115448_b0105","doi-asserted-by":"crossref","first-page":"2282","DOI":"10.1007\/s10147-021-02007-6","article-title":"Adjuvant radiotherapy improves overall survival when added to surgery and chemotherapy for uterine carcinosarcoma: a surveillance, epidemiology, and end results analysis","volume":"26","author":"Squires","year":"2021","journal-title":"Int J Clin Oncol"},{"issue":"536","key":"10.1016\/j.ejogrb.2026.115448_b0110","first-page":"e1","article-title":"The role of radiation in improving survival for early-stage carcinosarcoma and leiomyosarcoma","volume":"199","author":"Wright","year":"2008","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ejogrb.2026.115448_b0115","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.ygyno.2025.03.004","article-title":"Role of adjuvant radiotherapy modality on clinical outcomes for early-stage uterine carcinosarcoma","volume":"195","author":"Tyan","year":"2025","journal-title":"Gynecol Oncol"}],"container-title":["European Journal of Obstetrics & Gynecology and Reproductive Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211526005166?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211526005166?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T21:00:43Z","timestamp":1790197243000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301211526005166"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":23,"alternative-id":["S0301211526005166"],"URL":"https:\/\/doi.org\/10.1016\/j.ejogrb.2026.115448","relation":{},"ISSN":["0301-2115"],"issn-type":[{"value":"0301-2115","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Improved overall survival with combined adjuvant chemotherapy and radiation in stage I uterine carcinosarcoma: A national cancer database study","name":"articletitle","label":"Article Title"},{"value":"European Journal of Obstetrics & Gynecology and Reproductive Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejogrb.2026.115448","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115448"}}