{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T08:43:06Z","timestamp":1792226586112,"version":"4.4.0"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejog.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Obstetrics & Gynecology and Reproductive Biology"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.ejogrb.2026.115494","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T15:48:17Z","timestamp":1791992897000},"page":"115494","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Serum sulfated glycosaminoglycan profiles and uteroplacental hemodynamics in preeclampsia: a cross-sectional study"],"prefix":"10.1016","volume":"327","author":[{"given":"Wei","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2835-9314","authenticated-orcid":false,"given":"Muhammad Asyab","family":"Afzal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3844-8458","authenticated-orcid":false,"given":"Hong Ming","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tie Ying","family":"Shan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi Qi","family":"Suo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"19","key":"10.1016\/j.ejogrb.2026.115494_b0005","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1056\/NEJMra2109523","article-title":"Preeclampsia","volume":"386","author":"Magee","year":"2022","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ejogrb.2026.115494_b0010","doi-asserted-by":"crossref","unstructured":"American College of Obstetricians and Gynecologists. Gestational hypertension and preeclampsia: ACOG Practice Bulletin No. 222. Obstet Gynecol. 2020;135(6):e237-60. Doi: 10.1097\/AOG.0000000000003891.","DOI":"10.1097\/AOG.0000000000003891"},{"issue":"14","key":"10.1016\/j.ejogrb.2026.115494_b0015","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1016\/j.jacc.2020.08.014","article-title":"Preeclampsia\u2014pathophysiology and clinical presentations: JACC state-of-the-art review","volume":"76","author":"Ives","year":"2020","journal-title":"J Am Coll Cardiol"},{"issue":"9461","key":"10.1016\/j.ejogrb.2026.115494_b0020","first-page":"785","volume":"365","author":"Sibai","year":"2005","journal-title":"Pre-eclampsia Lancet"},{"issue":"4","key":"10.1016\/j.ejogrb.2026.115494_b0025","doi-asserted-by":"crossref","first-page":"3781","DOI":"10.1002\/j.2040-4603.2022.tb00232.x","article-title":"Endothelial glycocalyx","volume":"12","author":"Foote","year":"2022","journal-title":"Compr Physiol"},{"issue":"17","key":"10.1016\/j.ejogrb.2026.115494_b0030","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1016\/j.jacc.2020.03.024","article-title":"Basic biology of extracellular matrix in the cardiovascular system, part 1\/4: JACC Focus Seminar","volume":"75","author":"Del Monte-Nieto","year":"2020","journal-title":"J Am Coll Cardiol"},{"issue":"1","key":"10.1016\/j.ejogrb.2026.115494_b0150","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s13054-018-2292-6","article-title":"The glycocalyx: a novel diagnostic and therapeutic target in sepsis","volume":"23","author":"Uchimido","year":"2019","journal-title":"Crit Care"},{"key":"10.1016\/j.ejogrb.2026.115494_b0035","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2022.1022770","article-title":"Circulating concentrations of glycocalyx degradation products in preeclampsia","volume":"13","author":"Carlberg","year":"2022","journal-title":"Front Physiol"},{"issue":"10","key":"10.1016\/j.ejogrb.2026.115494_b0040","doi-asserted-by":"crossref","first-page":"e136","DOI":"10.1161\/01.RES.0000101744.47866.D5","article-title":"Heparan sulfate proteoglycan is a mechanosensor on endothelial cells","volume":"93","author":"Florian","year":"2003","journal-title":"Circ Res"},{"issue":"1","key":"10.1016\/j.ejogrb.2026.115494_b0045","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0117133","article-title":"Endothelial surface glycocalyx can regulate flow-induced nitric oxide production in microvessels in vivo","volume":"10","author":"Yen","year":"2015","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.ejogrb.2026.115494_b0050","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1515\/jpm-2013-0097","article-title":"Placental syndecan-1 and sulphated glycosaminoglycans are decreased in preeclampsia","volume":"42","author":"Heyer-Chauhan","year":"2014","journal-title":"J Perinat Med"},{"key":"10.1016\/j.ejogrb.2026.115494_b0055","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.cca.2014.07.023","article-title":"Evaluation of glycosaminoglycans and heparanase in placentas of women with preeclampsia","volume":"437","author":"Fam\u00e1","year":"2014","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.ejogrb.2026.115494_b0060","article-title":"Extracellular matrix components in preeclampsia","volume":"565","author":"Fam\u00e1","year":"2025","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.ejogrb.2026.115494_b0070","doi-asserted-by":"crossref","unstructured":"Warda M, Zhang F, Radwan M, Zhang Z, Kim N, Kim YN, Linhardt RJ, Han J. Is human placenta proteoglycan remodeling involved in pre-eclampsia? Glycoconj J. 2008 Jul;25(5):441-50. doi: 10.1007\/s10719-007-9090-8. Epub 2007 Dec 27. PMID: 18161024; PMCID: PMC2630190.","DOI":"10.1007\/s10719-007-9090-8"},{"key":"10.1016\/j.ejogrb.2026.115494_b0065","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.placenta.2025.04.026","article-title":"Maternal serum heparan sulfate in preeclampsia pathophysiology: Insights from a systematic review and meta-analysis","volume":"173","author":"G\u00f3mez-Guti\u00e9rrez","year":"2026","journal-title":"Placenta"},{"issue":"1","key":"10.1016\/j.ejogrb.2026.115494_b0145","doi-asserted-by":"crossref","first-page":"4387","DOI":"10.1038\/s41598-021-82972-0","article-title":"Soluble syndecan-1 and glycosaminoglycans in preeclamptic and normotensive pregnancies","volume":"11","author":"Hassani Lahsinoui","year":"2021","journal-title":"Sci Rep"},{"issue":"1","key":"10.1016\/j.ejogrb.2026.115494_b0075","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1161\/HYPERTENSIONAHA.117.10803","article-title":"Hypertensive disorders of pregnancy: ISSHP classification, diagnosis, and management recommendations for international practice","volume":"72","author":"Brown","year":"2018","journal-title":"Hypertension"},{"issue":"2","key":"10.1016\/j.ejogrb.2026.115494_b0080","first-page":"173","article-title":"Improved quantitation and discrimination of sulphated glycosaminoglycans by use of dimethylmethylene blue","volume":"883","author":"Farndale","year":"1986","journal-title":"BBA"},{"key":"10.1016\/j.ejogrb.2026.115494_b0085","first-page":"115","article-title":"The dimethylmethylene blue assay (DMMB) for the quantification of sulfated glycosaminoglycans","volume":"2566","author":"Ladner","year":"2022","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.ejogrb.2026.115494_b0090","doi-asserted-by":"crossref","first-page":"224","DOI":"10.22203\/eCM.v029a17","article-title":"Fact versus artifact: avoiding erroneous estimates of sulfated glycosaminoglycan content using the dimethylmethylene blue colorimetric assay for tissue-engineered constructs","volume":"29","author":"Zheng","year":"2015","journal-title":"Eur Cells Mater"},{"issue":"1\u20132","key":"10.1016\/j.ejogrb.2026.115494_b0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jchromb.2006.02.049","article-title":"Electrophoretic approaches to the analysis of complex polysaccharides","volume":"834","author":"Volpi","year":"2006","journal-title":"J Chromatogr B"},{"issue":"5","key":"10.1016\/j.ejogrb.2026.115494_b0100","first-page":"385","article-title":"Determination of sulphate\/uronic acid ratios in glycosaminoglycans separated by electrophoresis on cellulose acetate","volume":"43","author":"Poulsen","year":"1983","journal-title":"Scand J Clin Lab Invest"},{"issue":"24","key":"10.1016\/j.ejogrb.2026.115494_b0155","doi-asserted-by":"crossref","first-page":"6030","DOI":"10.1021\/ac015577t","article-title":"Tandem mass spectrometric determination of the 4S\/6S sulfation sequence in chondroitin sulfate oligosaccharides","volume":"73","author":"Zaia","year":"2001","journal-title":"Anal Chem"},{"issue":"2","key":"10.1016\/j.ejogrb.2026.115494_b0105","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/0009-8981(67)90167-2","article-title":"Determination of hydroxyproline","volume":"18","author":"Stegemann","year":"1967","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.ejogrb.2026.115494_b0110","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/0003-2697(62)90095-7","article-title":"A modified uronic acid carbazole reaction","volume":"4","author":"Bitter","year":"1962","journal-title":"Anal Biochem"},{"issue":"4","key":"10.1016\/j.ejogrb.2026.115494_b0115","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1002\/uog.20157","article-title":"Fetal Medicine Foundation reference ranges for umbilical artery and middle cerebral artery pulsatility index and cerebroplacental ratio","volume":"53","author":"Ciobanu","year":"2019","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"4","key":"10.1016\/j.ejogrb.2026.115494_b0120","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.ajog.2012.01.022","article-title":"Society for Maternal-Fetal Medicine. Doppler assessment of the fetus with intrauterine growth restriction","volume":"206","author":"Berkley","year":"2012","journal-title":"Am J Obstet Gynecol"},{"issue":"3","key":"10.1016\/j.ejogrb.2026.115494_b0125","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1097\/00006250-198309000-00001","article-title":"The fetal biophysical profile and its predictive value","volume":"62","author":"Vintzileos","year":"1983","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ejogrb.2026.115494_b0130","doi-asserted-by":"crossref","unstructured":"American College of Obstetricians and Gynecologists. Antepartum fetal surveillance: ACOG Practice Bulletin No. 229. Obstet Gynecol. 2021;137(6):e116-27. Doi: 10.1097\/AOG.0000000000004410.","DOI":"10.1097\/AOG.0000000000004410"},{"key":"10.1016\/j.ejogrb.2026.115494_b0135","article-title":"Fetal and neonatal middle cerebral artery hemodynamic changes and significance under ultrasound detection in hypertensive disorder complicating pregnancy patients with different severities","volume":"2022","author":"Zhou","year":"2022","journal-title":"Comput Math Methods Med"},{"issue":"6","key":"10.1016\/j.ejogrb.2026.115494_b0140","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1002\/uog.3805","article-title":"Fetal middle cerebral to uterine artery pulsatility index ratios in normal and pre-eclamptic pregnancies","volume":"28","author":"Simanaviciute","year":"2006","journal-title":"Ultrasound Obstet Gynecol"}],"container-title":["European Journal of Obstetrics & Gynecology and Reproductive Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211526005622?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211526005622?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T08:33:07Z","timestamp":1792225987000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301211526005622"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":31,"alternative-id":["S0301211526005622"],"URL":"https:\/\/doi.org\/10.1016\/j.ejogrb.2026.115494","relation":{},"ISSN":["0301-2115"],"issn-type":[{"value":"0301-2115","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Serum sulfated glycosaminoglycan profiles and uteroplacental hemodynamics in preeclampsia: a cross-sectional study","name":"articletitle","label":"Article Title"},{"value":"European Journal of Obstetrics & Gynecology and Reproductive Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejogrb.2026.115494","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115494"}}