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In this model, continuous morphine infusion (5 mg\/day) was shown to be effective during the first week of its administration but became almost completely ineffective by the end of the second week; F 13640's effectiveness (0.63 mg\/day) remained unchanged during two weeks. Here, we examined the effects of combining F 13640 infusion with that of morphine. During the first week, the combination of the two agents produced a magnitude of effect that was similar to that of morphine when given alone and larger than that of F 13640 alone. During the second week, the combination produced an effect that was similar to that of F 13640 alone, and more effective than that of morphine alone. The latter data suggest that the 5\u2010HT<jats:sub>1A<\/jats:sub> agonist, F 13640, inhibits the development of tolerance to morphine in this model. However, it is also possible that little, if any, interaction occurred between the different mechanisms initiated by opioid and 5\u2010HT<jats:sub>1A<\/jats:sub> receptor activation, and that the anti\u2010allodynic effect that remained by the end of the two\u2010week treatment period is due solely to 5\u2010HT<jats:sub>1A<\/jats:sub> receptor activation. The stable effects of F 13640 during the second week of treatment surpassed those of morphine and were not improved by the addition of morphine to F 13640.<\/jats:p>","DOI":"10.1016\/j.ejpain.2004.01.002","type":"journal-article","created":{"date-parts":[[2004,2,27]],"date-time":"2004-02-27T10:21:49Z","timestamp":1077877309000},"page":"547-554","source":"Crossref","is-referenced-by-count":16,"title":["Effects of the combined continuous administration of morphine and the high\u2010efficacy 5\u2010HT<sub>1A<\/sub> agonist, F 13640 in a rat model of trigeminal neuropathic pain"],"prefix":"10.1002","volume":"8","author":[{"given":"Kristof R.","family":"Deseure","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugo F.","family":"Adriaensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francis C.","family":"Colpaert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,1,11]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"53","article-title":"Pharmacologic treatment of neuropathic pain","volume":"101","author":"Attal N.","year":"2001","journal-title":"Acta Neurol. 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