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Similar to a variety of other chronic pain conditions and certain affective disorders, IBS is more prevalent amongst women, both in population\u2010based studies as well as in clinic\u2010based surveys. Non\u2010painful gastrointestinal symptoms, constipation and somatic discomfort are more commonly reported by female IBS patients. While perceptual differences to rectosigmoid stimulation are only observed following repeated noxious stimulation of the gut, sex\u2010related differences in certain sympathetic nervous system (SNS) responses to rectosigmoid stimulation are consistently seen. 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