{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T15:27:24Z","timestamp":1765294044717},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,1,11]],"date-time":"2012-01-11T00:00:00Z","timestamp":1326240000000},"content-version":"vor","delay-in-days":2476,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2005,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Background and aims<\/jats:italic>: Afferent large fibre impairment has been reported as a useful predictor of postherpetic neuralgia (PHN) in patients with acute herpes zoster infection, using an electromechanical device to provide quantitative vibrametry. We aimed to demonstrate a clinically significant increase in vibration threshold in individuals with PHN compared to age\u2010matched controls, using the portable and affordable Rydel\u2014Seiffer graduated tuning fork.<\/jats:p><jats:p><jats:italic>Methods<\/jats:italic>: We studied 45 PHN subjects aged over 55 years, and 45 age\u2010matched controls with no history of herpes zoster infection. We excluded subjects with a history of disorders associated with neuropathy or immunocompromise. Measurements were performed at the ulnar styloid process and the head of the first metatarsal on the right side, in a warm room with the subject seated. Readings were taken in triplicate and the data analysed by a repeated measures design.<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>: We observed a significant difference in vibration threshold at both wrist and toe between the PHN and control groups (<jats:italic>p<\/jats:italic>&lt;0.001). Age\u2010stratification of subjects produced an increased and clinically useful difference between the two groups at both sites in subjects between 55 and 70 years (<jats:italic>p<\/jats:italic>&lt;0.0001).<\/jats:p><jats:p><jats:italic>Conclusions<\/jats:italic>: We have shown a statistically significant decrease in vibration sensitivity in individuals with PHN aged 55\u201370 years compared to age\u2010matched healthy controls, using the Rydel\u2014Seiffer graduated tuning fork. A prospective study of patients with acute zoster infection is needed to determine the sensitivity and specificity of the graduated tuning fork in predicting PHN in patients with acute zoster infection.<\/jats:p>","DOI":"10.1016\/j.ejpain.2004.05.001","type":"journal-article","created":{"date-parts":[[2004,6,9]],"date-time":"2004-06-09T20:56:45Z","timestamp":1086814605000},"page":"167-171","source":"Crossref","is-referenced-by-count":21,"title":["Use of the Rydel\u2014Seiffer graduated tuning fork in the assessment of vibration threshold in postherpetic neuralgia patients and healthy controls"],"prefix":"10.1002","volume":"9","author":[{"given":"Tessa L.","family":"Whitton","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert W.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.Timothy.","family":"Lovell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,1,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(97)00105-X"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.288.6433.1793"},{"issue":"4","key":"e_1_2_6_4_1","first-page":"335","article-title":"The lifetime occurrence of herpes zoster and prevalence of postherpetic neuralgia: a retrospective study in an elderly population","volume":"3","author":"Bowsher D.R.","year":"1999","journal-title":"J. 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