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Sensitization of the nociceptive system may play a role for non\u2010recovery after whiplash injury.<\/jats:p><jats:p><jats:italic>Aims:<\/jats:italic> This study examined if tolerance to endure pain stimuli may predict outcome in whiplash injury.<\/jats:p><jats:p>In a prospective fashion, 141 acute whiplash patients exposed to rear\u2010end car collision (WAD grade 1\u20133) and 40 ankle\u2010injured controls were followed and exposed to a cold pressor test, respectively, 1 week, 1, 3, 6 and 12 months after the injury. VAS score of pain and discomfort was obtained before, during and after immersion of the dominant hand into cold water for 2 min.<\/jats:p><jats:p>The McGill Pain Questionnaire showed that ankle\u2010injured controls had higher initial pain scores than the corresponding whiplash group, while whiplash\u2010injured subjects had higher scores at 6 months; pain scores being similar at other time points. No difference was found in cold pressor pain between recovered whiplash patients and ankle\u2010injured subjects. Non\u2010recovery was only encountered in whiplash injury. Eleven non\u2010recovered whiplash patients (defined as: handicap after 1 year) showed reduced time to peak pain from 1 week to 3 months (<jats:italic>P<\/jats:italic> &lt; 0.001), 6 months (<jats:italic>P<\/jats:italic> &lt; 0.01), but not 12 months after the injury. A larger pain area was seen in non\u2010recovered vs. recovered whiplash\u2010injured subjects during the entire observation period (<jats:italic>P<\/jats:italic> &lt; 0.001).<\/jats:p><jats:p>Non\u2010recovery after whiplash was associated with initially reduced cold pressor pain endurance and increased peak pain, suggesting that dysfunction of central pain modulating control systems plays a role in chronic pain after acute whiplash injury.<\/jats:p>","DOI":"10.1016\/j.ejpain.2004.11.011","type":"journal-article","created":{"date-parts":[[2004,12,31]],"date-time":"2004-12-31T12:45:15Z","timestamp":1104497115000},"page":"561-561","source":"Crossref","is-referenced-by-count":135,"title":["Reduced cold pressor pain tolerance in non\u2010recovered whiplash patients: a 1\u2010year prospective study"],"prefix":"10.1002","volume":"9","author":[{"given":"Helge","family":"Kasch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erisela","family":"Qerama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flemming Winther","family":"Bach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Troels Staehelin","family":"Jensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,1,11]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"SOMEDIC User's manual for algometer type 1. 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