{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:46:52Z","timestamp":1787237212975,"version":"build-2736575974"},"reference-count":44,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,1,9]],"date-time":"2012-01-09T00:00:00Z","timestamp":1326067200000},"content-version":"vor","delay-in-days":1530,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2007,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Background:<\/jats:italic>\n                    Despite a broad clinical use, the mechanism of action of SCS is poorly understood. Current information suggests that the effects of SCS are mediated by a complex set of interactions at several levels of the nervous system including spinal and supraspinal mechanisms.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Aims:<\/jats:italic>\n                    The study was undertaken to investigate the influence of SCS on distinct parameters of cortical excitability using single\u2010 and paired\u2010pulse transcranial magnetic stimulation (TMS).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Methods:<\/jats:italic>\n                    Five patients with chronic neuropathic pain were examined with the SCS stimulator on and off by means of TMS. Pain was assessed using a visual\u2010analogue scale. Electrophysiological and pain parameters of patients during this procedure were compared by means of a linear mixed effect model.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Results:<\/jats:italic>\n                    SCS induced a significant modulation of cortical excitability, especially by influencing the parameter \u201cintracortical facilitation\u201d (\n                    <jats:italic>t<\/jats:italic>\n                    =\u22122.657; df=8;\n                    <jats:italic>p<\/jats:italic>\n                    =0.029). A significant relationship between this parameter and \u201cperceived pain\u201d could be obtained (\n                    <jats:italic>t<\/jats:italic>\n                    =\u22124.798; df=8;\n                    <jats:italic>p<\/jats:italic>\n                    =0.002).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Conclusions:<\/jats:italic>\n                    These results suggest that SCS is able to influence neurobiological processes at the supraspinal level and that clinical effects of SCS may be at least in part of cortical origin.\n                  <\/jats:p>","DOI":"10.1016\/j.ejpain.2007.01.004","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T16:29:55Z","timestamp":1172766595000},"page":"863-868","source":"Crossref","is-referenced-by-count":44,"title":["Effects of spinal cord stimulation on cortical excitability in patients with chronic neuropathic pain: A pilot 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