{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T13:06:33Z","timestamp":1790082393927,"version":"4.0.1"},"reference-count":48,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,1,9]],"date-time":"2012-01-09T00:00:00Z","timestamp":1326067200000},"content-version":"vor","delay-in-days":1469,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2008,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>NMDA\u2010receptors are a major target in the prevention and treatment of hyperalgesic pain states in neuropathic pain. However, previous studies revealed equivocal results depending on study design and efficacy parameters.<\/jats:p><jats:p>We tested the <jats:italic>analgesic<\/jats:italic> (generalized reduction of generation and processing of nociceptive signalling) and <jats:italic>anti\u2010hyperalgesic<\/jats:italic> (prevention of central sensitization) properties of the NMDA\u2010receptor antagonist neramexane and the potassium channel opener flupirtine in the intradermal capsaicin injection model. Furthermore, we tested the effect on pain summation (wind up). Eighteen healthy subjects received either a single dose of neramexane (40mg p.o.), flupirtine (100mg) or placebo in a double\u2010blind, randomized, cross\u2010over study.<\/jats:p><jats:p>Pain evoked by intradermal capsaicin injection as well as pain evoked by pinpricks was significantly reduced by neramexane (\u221222% to \u221230% vs. placebo) in the non\u2010sensitized skin indicating a marked analgesic effect. Moreover, dynamic mechanical allodynia (pain to light touch) was also significantly attenuated by neramexane (\u221228% vs. placebo). However, static secondary hyperalgesia to pinprick stimuli after capsaicin injection was not significantly reduced (\u22129% vs. placebo). Flupirtine showed no analgesic or anti\u2010hyperalgesic effect. Mechanically\u2010evoked wind up of pain sensation was not affected by any treatment.<\/jats:p><jats:p>The results suggests that in a human surrogate model of neurogenic hyperalgesia a single low\u2010dose of neramexane had a marked analgesic effect in the sensitized and in the non\u2010sensitized state and thus may be a useful drug to treat the enhanced pain sensitivity in neuropathic pain patients. Its efficacy may be based on analgesia rather than anti\u2010hyperalgesia or anti\u2010windup. In contrast, flupirtine showed neither an analgesic nor an anti\u2010hyperalgesic effect at a dose used for the treatment of postoperative pain.<\/jats:p>","DOI":"10.1016\/j.ejpain.2007.02.002","type":"journal-article","created":{"date-parts":[[2007,4,21]],"date-time":"2007-04-21T11:10:29Z","timestamp":1177153829000},"page":"17-29","source":"Crossref","is-referenced-by-count":26,"title":["Antihyperalgesic and analgesic properties of the <i>N<\/i>\u2010methyl\u2010<scp>d<\/scp>\u2010aspartate (NMDA) receptor antagonist neramexane in a human surrogate model of neurogenic 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