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In this study we examined if the acute stress reaction following a whiplash injury predicted long\u2010term sequelae. Participants with acute whiplash\u2010associated symptoms after a motor vehicle accident were recruited from emergency units and general practitioners. The predictor variable was the sum score of the impact of event scale (IES) completed within 10 days after the accident. The main outcome\u2010measures were neck pain and headache, neck disability, general health, and working ability one year after the accident. A total of 737 participants were included and completed the IES, and 668 (91%) participated in the 1\u2010year follow\u2010up. A baseline IES\u2010score denoting a moderate to severe stress response was obtained by 13% of the participants. This was associated with increased risk of considerable persistent pain (OR=3.3; 1.8\u20135.9), neck disability (OR=3.2; 1.7\u20136.0), reduced working ability (OR=2.8; 1.6\u20134.9), and lowered self\u2010reported general health one year after the accident. These associations were modified by baseline neck pain intensity. It was not possible to distinguish between participants who recovered and those who did not by means of the IES (AUC=0.6). In conclusion, the association between the acute stress reaction and persistent WAD suggests that post traumatic stress reaction may be important to consider in the early management of whiplash injury. However, the emotional response did not predict chronicity in individuals.<\/jats:p>","DOI":"10.1016\/j.ejpain.2007.07.008","type":"journal-article","created":{"date-parts":[[2007,10,2]],"date-time":"2007-10-02T17:13:56Z","timestamp":1191345236000},"page":"455-463","source":"Crossref","is-referenced-by-count":76,"title":["Acute stress response and recovery after whiplash injuries. 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