{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T11:17:55Z","timestamp":1788175075633,"version":"build-2803163510"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,1,9]],"date-time":"2012-01-09T00:00:00Z","timestamp":1326067200000},"content-version":"vor","delay-in-days":1256,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2008,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Mice lacking the serotonin\u2010transporter (5\u2010HTT\u2010\/\u2010 mice) develop reduced thermal hyperalgesia after nerve injury, concomitant with reduced serotonin (5\u2010HT) levels in nervous tissue. Here we investigated pain behaviour in 5\u2010HTT\u2010\/\u2010 mice compared to their wild type littermates after hind paw inflammation induced by complete Freund's adjuvant (CFA). We used standard tests for pain behaviour, high performance liquid chromatography for measurement of 5\u2010HT, and immunohistochemistry of hind paw skin tissue and L5 dorsal root ganglia (DRG) to measure local inflammation and nerve injury. After intraplantar CFA injection, hyperalgesia to heat was attenuated in 5\u2010HTT\u2010\/\u2010 mice compared to wild type mice. Their 5\u2010HT levels in nervous and adrenal tissue were reduced. An intraplantar injection of 5\u2010HT four days after CFA transiently brought withdrawal latencies of 5\u2010HTT\u2010\/\u2010 mice down to the level of wild type mice, thus rescuing the phenotype and supporting the role of 5\u2010HT in the development of CFA\u2010induced thermal hyperalgesia. The density of intraepidermal nerve fibres in plantar skin after CFA injection was reduced to a higher degree in 5\u2010HTT\u2010\/\u2010 mice than in wild type mice, suggesting greater peripheral nerve injury in the knock\u2010out mice during hind paw inflammation. Accordingly, a higher number of injured DRG neurons was identified by activating transcription factor 3 (ATF3) staining in 5\u2010HTT\u2010\/\u2010 mice after CFA. We conclude that the phenotype of 5\u2010HTT\u2010\/\u2010 mice leads to reduced inflammatory pain due to reduced tissue 5\u2010HT levels and to greater peripheral nerve injury after inflammation. Human variants of the 5\u2010HTT genotypes might be part of the factors determining the extent of nerve injury and hyperalgesia in inflammation.<\/jats:p>","DOI":"10.1016\/j.ejpain.2007.11.009","type":"journal-article","created":{"date-parts":[[2008,1,11]],"date-time":"2008-01-11T16:03:14Z","timestamp":1200067394000},"page":"790-797","source":"Crossref","is-referenced-by-count":27,"title":["Reduced thermal hyperalgesia and enhanced peripheral nerve injury after hind paw inflammation in mice lacking the serotonin\u2010transporter"],"prefix":"10.1002","volume":"12","author":[{"given":"Florian","family":"Palm","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainald","family":"M\u00f6ssner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manfred","family":"Gerlach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Bischofs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Riederer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus\u2010Peter","family":"Lesch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Sommer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,1,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2003.07.016"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.53.4.649"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(88)90209-6"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01837911"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0270(94)90144-9"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1993.69.4.1071"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1965.10480843"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/75.2.125"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.1993.1302075.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2000.00126.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3908(01)00142-3"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(99)00111-6"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/37.10.1077"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(88)90026-7"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-0102(02)00234-1"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00162a016"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-328X(01)00226-1"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2005.08.010"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01294726"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(00)02190-9"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2004.05.017"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2004.11.001"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2005.05.046"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2003.01836.x"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1124\/mi.4.2.8"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2006.02.033"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2003.02504.x"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-006-0020-4"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(97)01327-9"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2004.10.002"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2006.04.030"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1490"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1006\/mcne.1999.0814"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000265062.92340.a5"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-02-00708.2003"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3908(99)00022-2"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2004.05.010"}],"container-title":["European Journal of Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.ejpain.2007.11.009","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.ejpain.2007.11.009","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T08:48:24Z","timestamp":1697446104000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1016\/j.ejpain.2007.11.009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,8]]},"references-count":37,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2008,8]]}},"alternative-id":["10.1016\/j.ejpain.2007.11.009"],"URL":"https:\/\/doi.org\/10.1016\/j.ejpain.2007.11.009","archive":["Portico"],"relation":{},"ISSN":["1090-3801","1532-2149"],"issn-type":[{"value":"1090-3801","type":"print"},{"value":"1532-2149","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,8]]}}}