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Recently, some studies have indicated that sympathetic trunks are closely related to discogenic low\u2010back pain. However, sympathetic trunk resection can severely affect the function of the abdominal organs and lower extremities and may cause retrograde ejaculation in human beings. This study was initiated to evaluate the role of selective transection of the L2 ramus of the nociceptive pathway in the lumbar intervertebral discs in rats, by using the fluorogold (FG) retrograde transport method and immunohistochemistry of substance P (SP). Of the FG\u2010labeled neurons in the L2 and L5 dorsal root ganglia (DRGs), the cross\u2010sectional area of the SP\u2010immunoreactive (ir) neurons ranged from 210 to 1140\u03bcm<jats:sup>2<\/jats:sup>; the mean cross\u2010sectional area was 652\u00b1320\u03bcm<jats:sup>2<\/jats:sup>. We demonstrated that FG\u2010labeled SP\u2010ir neurons in L2 DRGs decreased when FG was applied to the ventral or dorsal portions of L5\u20136 discs. The results indicated that the L2 ramus communicans played an important role in the afferent pathway of both the ventral and dorsal portions of the L5\u20136 disc. Nociceptive information from the L5\u20136 disc may be transmitted mainly by L2 DRG neurons through the L2 ramus communicans.<\/jats:p>","DOI":"10.1016\/j.ejpain.2007.12.001","type":"journal-article","created":{"date-parts":[[2008,2,5]],"date-time":"2008-02-05T13:43:44Z","timestamp":1202219024000},"page":"798-803","source":"Crossref","is-referenced-by-count":15,"title":["Effect of the L2 ramus communicans on the nociceptive pathway in lumbar intervertebral discs in 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