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Male Sprague\u2013Dawley rats were divided into five groups and received intrathecal saline or lidocaine (2, 6.5, 15, and 35mg\/kg) 7 days after loose sciatic ligation. Respiratory depression and hemodynamic instability were found to become more severe as doses of lidocaine increased during intrathecal therapy. Two animals in the group receiving 35mg\/kg lidocaine developed pulmonary oedema and died. Behavioral tests indicated that 6.5, 15, and 35mg\/kg intrathecal lidocaine showed different degrees of reversal of thermal hyperalgesia, and lasted for 2\u20138 days, while 2mg\/kg lidocaine did not. The inhibition of tactile allodynia was only observed in rats receiving 15 and 35mg\/kg lidocaine, and the anti\u2010allodynic effects were identical in these two groups. Histopathologic examinations on the spinal cords revealed mild changes in rats receiving 2\u201315mg\/kg lidocaine. However, lesions were severe after administration of 35mg\/kg lidocaine. These findings indicate that intrathecal lidocaine has prolonged therapeutic effects on established neuropathic pain. The balance between sympathetic and parasympathetic nervous activities could be well preserved in most cases, except for 35mg\/kg. Considering the ratio between useful effects and side effects, doses of 15mg\/kg are suitable for intrathecal injection for relief of neuropathic pain.<\/jats:p>","DOI":"10.1016\/j.ejpain.2008.03.013","type":"journal-article","created":{"date-parts":[[2008,5,17]],"date-time":"2008-05-17T08:52:33Z","timestamp":1211014353000},"page":"130-137","source":"Crossref","is-referenced-by-count":23,"title":["Effects of intrathecal lidocaine on hyperalgesia and allodynia following chronic constriction injury in rats"],"prefix":"10.1002","volume":"13","author":[{"given":"Jie","family":"Tian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiwen","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diansan","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yichao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangrui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,1,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(88)90209-6"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199510000-00017"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(94)00117-W"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612054865028"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200301000-00031"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(00)00229-3"},{"key":"e_1_2_7_8_1","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/S0022-3565(24)29197-7","article-title":"Pharmacology of opioid and nonopioid analgesics in chronic pain states","volume":"299","author":"Martin T.J.","year":"2001","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(00)00272-4"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199801000-00025"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(98)00187-0"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2000.tb06673.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(98)00245-0"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(02)00028-3"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0270(95)00164-6"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(98)00243-7"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00115550-200409000-00010"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.103.050039"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.14.7675"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(76)90029-9"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348949710601214"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348949410301009"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(96)03176-4"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03017413"}],"container-title":["European Journal of Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.ejpain.2008.03.013","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.ejpain.2008.03.013","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T10:01:24Z","timestamp":1738231284000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1016\/j.ejpain.2008.03.013"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2]]},"references-count":23,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,2]]}},"alternative-id":["10.1016\/j.ejpain.2008.03.013"],"URL":"https:\/\/doi.org\/10.1016\/j.ejpain.2008.03.013","archive":["Portico"],"relation":{},"ISSN":["1090-3801","1532-2149"],"issn-type":[{"value":"1090-3801","type":"print"},{"value":"1532-2149","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,2]]}}}