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Although some evidences suggest that sleep and pain may interact in a complex way, polysomnographic studies in animals with acute nociception are limited in number.<\/jats:p><jats:p><jats:italic>Aims:<\/jats:italic> This study was carried out in order to evaluate the effect of intra\u2010articular knee injection of uric acid on sleep\u2010wake patterns.<\/jats:p><jats:p><jats:italic>Methods:<\/jats:italic> Surgical electrode implantation was performed in seven anesthetized Wistar rats to carry out 10h polysomnographic recordings. Acute nociception was induced by the intra\u2010articular administration of 30% uric acid crystals into the knee joint of the right hind limb. Two recordings before and after intra\u2010articular drug administration were obtained. Sleep\u2010wake parameters were classified as (i) wakefulness (W), (ii) slow wave sleep (SWS), and (iii) rapid eye movement (REM) sleep. Frequency and duration from each parameter were evaluated under the two above\u2010mentioned conditions.<\/jats:p><jats:p><jats:italic>Results:<\/jats:italic> Intra\u2010articular administration of uric acid induced: (i) an increased duration of wakefulness (<jats:italic>p<\/jats:italic>=0.014), (ii) a decrement in the duration (<jats:italic>p<\/jats:italic>=0.001) and number of events (<jats:italic>p<\/jats:italic>=0.027) in REM sleep, and (iii) a decrement in the total sleep time (<jats:italic>p<\/jats:italic>=0.001). SWS did not present statistical differences between groups.<\/jats:p><jats:p><jats:italic>Conclusions:<\/jats:italic> These data suggest that a nociceptive stimulus, induced by the intra\u2010articular administration of uric acid, alters the sleep\u2010wake equilibrium with REM sleep being particularly altered. However, further research concerning pain\u2013sleep interaction is needed.<\/jats:p>","DOI":"10.1016\/j.ejpain.2008.04.002","type":"journal-article","created":{"date-parts":[[2008,5,24]],"date-time":"2008-05-24T10:18:42Z","timestamp":1211624322000},"page":"146-153","source":"Crossref","is-referenced-by-count":14,"title":["Effect of acute gouty arthritis on sleep patterns: A preclinical study"],"prefix":"10.1002","volume":"13","author":[{"given":"Uriah","family":"Guevara\u2010L\u00f3pez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fructuoso","family":"Ayala\u2010Guerrero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfredo","family":"Covarrubias\u2010G\u00f3mez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco 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