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Two of the sites were pre\u2010treated with the \u03b1<jats:sub>1<\/jats:sub>\u2010antagonist terazosin, to determine whether the effect of phenylephrine was mediated by \u03b1<jats:sub>1<\/jats:sub>\u2010adrenoceptors. Terazosin was administered before the burn injury at one site, and after the burn injury at the other site. In another 15 participants, the nociceptive effect of the \u03b1<jats:sub>2<\/jats:sub>\u2010adrenoceptor agonist clonidine was investigated with and without prior treatment with the \u03b1<jats:sub>2<\/jats:sub>\u2010antagonist rauwolscine. Drugs were introduced into the skin by iontophoresis, and burns were induced by heating the skin to 48\u00b0C for 2min. Heat pain thresholds to a temperature ramp (0.5\u00b0C\/s), and heat pain ratings to a thermal stimulus (45\u00b0C, 7s), were determined before and after the administration of each drug. Thermal hyperalgesia provoked by phenylephrine was inhibited by terazosin administered after the burn injury, but not by terazosin administered before the burn injury. However, neither \u03b1<jats:sub>2<\/jats:sub>\u2010adrenoceptor stimulation nor blockade affected sensitivity to heat in the mildly burnt skin. These findings suggest that stimulation of cutaneous \u03b1<jats:sub>1<\/jats:sub>\u2010adrenoceptors increased the excitability of heat\u2010sensitized nociceptive afferents. As terazosin was more effective when administered in burnt skin, an inflammatory response induced by the burn injury may have facilitated access of adrenergic agents to \u03b1<jats:sub>1<\/jats:sub>\u2010adrenoceptors.<\/jats:p>","DOI":"10.1016\/j.ejpain.2008.04.008","type":"journal-article","created":{"date-parts":[[2008,6,4]],"date-time":"2008-06-04T09:02:58Z","timestamp":1212570178000},"page":"273-279","source":"Crossref","is-referenced-by-count":27,"title":["\u03b1<sub>1<\/sub>\u2010Adrenoceptors augment thermal hyperalgesia in mildly burnt skin"],"prefix":"10.1002","volume":"13","author":[{"given":"Peter 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