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Morphine rescue medication was available <jats:italic>via<\/jats:italic> a PCA pump. The key index of analgesic activity was determined as the amount of morphine consumed by the patient over 12 and 24h after M6G administration. Time to first use of rescue medication, VAS and global pain assessment scales were also recorded. Safety was assessed by monitoring supine blood pressure, heart rate, respiratory rate and body temperature and typical opioid side\u2010effects of PONV and sedation.<\/jats:p><jats:p><jats:italic>Results:<\/jats:italic> A total of 170 patients were dosed with study medication. M6G induced a dose\u2010related reduction in morphine use over 24\u2010h that reached statistical significance compared to placebo at M6G 30mg\/70kg. There was no clear relationship between M6G dose and time to first use of PCA morphine. Pain relief was similar in all groups. M6G showed small, but inconsistent effects on the cardiovascular system and on sedation and no effects were observed on respiration or PONV.<\/jats:p><jats:p><jats:italic>Conclusion:<\/jats:italic> M6G induced long\u2010lasting dose\u2010related analgesic effects in postoperative patients with limited effects on cardiorespiratory systems or of opioid\u2010like side\u2010effects. M6G is an effective opioid for the treatment of moderate to severe postoperative pain.<\/jats:p>","DOI":"10.1016\/j.ejpain.2008.04.015","type":"journal-article","created":{"date-parts":[[2008,6,12]],"date-time":"2008-06-12T14:17:09Z","timestamp":1213280229000},"page":"293-299","source":"Crossref","is-referenced-by-count":20,"title":["Efficacy and safety of morphine\u20106\u2010glucuronide (M6G) for postoperative pain relief: A randomized, double\u2010blind study"],"prefix":"10.1002","volume":"13","author":[{"given":"T.W.","family":"Smith","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander R.","family":"Binning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Dahan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,1,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200603000-00025"},{"key":"e_1_2_6_3_1","unstructured":"BinningS. 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