{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T03:40:23Z","timestamp":1771472423978,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,1,9]],"date-time":"2012-01-09T00:00:00Z","timestamp":1326067200000},"content-version":"vor","delay-in-days":983,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2009,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>Background<\/jats:italic>: A systematic review from the Cochrane Collaboration stated that alpha\u2010lipoic acid (ALA) may help in the management of burning mouth syndrome (BMS). Because all of the data on ALA came from a single group, it has been stressed that its effectiveness should be reproduced in other populations.<\/jats:p><jats:p><jats:italic>Aim<\/jats:italic>: A double\u2010blind, randomized, placebo\u2010controlled study, including two test groups (Group A and Group B) and one control group (Group C), was carried out to evaluate the efficacy of systemic ALA (400mg) and ALA (400mg) plus vitamins in the treatment of BMS.<\/jats:p><jats:p><jats:italic>Methods<\/jats:italic>: Sixty\u2010six patients (54 females and 12 males) were included in an 8\u2010week trial. Symptoms were evaluated by using a visual analogue scale (VAS) and the McGill Pain Questionnaire (MPQ) at 0, 2, 4, 8 and 16 weeks.<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>: Fifty\u2010two patients (43 females and 9 males, aged 67.3\u00b111.9 years) completed the study. All three groups had significant reductions in the VAS score and in the mixed affective\/evaluative subscale of the MPQ; the responders\u2019 rate (at least 50% improvement in the VAS score) was about 30%. No significant differences were observed among the groups either in the response rate or in the mean latency of the therapeutic effect.<\/jats:p><jats:p><jats:italic>Conclusions<\/jats:italic>: The fairly high placebo effect observed is very similar to data obtained from patients affected by atypical facial pain. This study failed to support a role for ALA in the treatment of BMS, and further investigations are needed to identify the cause of BMS in order to develop efficacious therapies.<\/jats:p>","DOI":"10.1016\/j.ejpain.2008.06.004","type":"journal-article","created":{"date-parts":[[2008,8,4]],"date-time":"2008-08-04T13:54:56Z","timestamp":1217858096000},"page":"492-496","source":"Crossref","is-referenced-by-count":73,"title":["Lack of efficacy of alpha\u2010lipoic acid in burning mouth syndrome: A double\u2010blind, randomized, placebo\u2010controlled 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