{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:35:15Z","timestamp":1786988115052,"version":"build-2736575974"},"reference-count":64,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,1,9]],"date-time":"2012-01-09T00:00:00Z","timestamp":1326067200000},"content-version":"vor","delay-in-days":860,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2009,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Temporomandibular disorders represent one of the major challenges in dentistry therapeutics. This study was undertaken to evaluate the time course of carrageenan\u2010induced inflammation in the rat temporomandibular joint (TMJ) and to investigate the role of tachykinin NK\n                    <jats:sub>1<\/jats:sub>\n                    receptors. Inflammation was induced by a single intra\u2010articular (i.art.) injection of carrageenan into the left TMJ (control group received sterile saline). Inflammatory parameters such as plasma extravasation, leukocyte influx and mechanical allodynia (measured as the head\u2010withdrawal force threshold) and TNF\u03b1 and IL\u20101\u03b2 concentrations were measured in the TMJ lavages at selected time\u2010points. The carrageenan\u2010induced responses were also evaluated after treatment with the NK\n                    <jats:sub>1<\/jats:sub>\n                    receptor antagonist SR140333. The i.art. injection of carrageenan into the TMJ caused a time\u2010dependent plasma extravasation associated with mechanical allodynia, and a marked neutrophil accumulation between 4 and 24h. Treatment with SR140333 substantially inhibited the increase in plasma extravasation and leukocyte influx at 4 and 24h, as well as the production of TNF\u03b1 and IL\u20101\u03b2 into the joint cavity, but failed to affect changes in head\u2010withdrawal threshold. The results obtained from the present TMJ\u2010arthritis model provide, for the first time, information regarding the time course of this experimental inflammatory process. In addition, our data show that peripheral NK\n                    <jats:sub>1<\/jats:sub>\n                    receptors mediate the production of both TNF\u03b1 and IL\u20101\u03b2 in the TMJ as well as some of the inflammatory signs, such as plasma extravasation and leukocyte influx, but not the nociceptive component.\n                  <\/jats:p>","DOI":"10.1016\/j.ejpain.2008.09.012","type":"journal-article","created":{"date-parts":[[2008,11,1]],"date-time":"2008-11-01T05:02:04Z","timestamp":1225515724000},"page":"812-819","source":"Crossref","is-referenced-by-count":40,"title":["Participation of peripheral tachykinin NK\n                    <sub>1<\/sub>\n                    receptors in the carrageenan\u2010induced inflammation of the rat temporomandibular joint"],"prefix":"10.1002","volume":"13","author":[{"given":"Alexandre","family":"Denadai\u2010Souza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Livia de 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