{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:47:19Z","timestamp":1772120839315,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2012,1,9]],"date-time":"2012-01-09T00:00:00Z","timestamp":1326067200000},"content-version":"vor","delay-in-days":830,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2009,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The aim was to study the introduction of the new low dose transdermal buprenorphine (LD\u2010TD\u2010BUP) in Norway, particularly with regard to former use and co\u2010medication with other potentially addictive drugs.<\/jats:p>\n                  <jats:p>The nationwide Norwegian Prescription Database contains information on all prescription drugs dispensed to individual non\u2010institutionalised patients, and we may follow all individuals who received LD\u2010TD\u2010BUP (Norspan\u00ae) after marketing on the Norwegian market on 15\/11\/05. We studied all prescriptions of opioids and other potentially addictive drugs to patients receiving at least two LD\u2010TD\u2010BUP prescriptions during 2004\u20132006. Poisson regressions were run with concomitant use of addictive drugs (yes, no) as the endpoint.<\/jats:p>\n                  <jats:p>Overall, 1884, non cancer individuals received at least two prescription of LD\u2010TD\u2010BUP. Of these 91.7% received prescriptions of other opioids and 58.6% of them had also been prescribed benzodiazepines\/carisoprodol before the prescription of LD\u2010TD\u2010BUP. Of the LD\u2010TD\u2010BUP users who received more than one prescription, 60% co\u2010medicated with at least one other potentially addictive drug, and 24% with at least two. In the multivariate analysis, the variables associated with a higher likelihood of using co\u2010medicated drugs were: previous use of benzodiazepines\/carisoprodol relative risk RR=16.7 (95% CI 10.4\u201326.9), previous use of opioids RR=4.0 (1.9\u20138.7) and younger age 20\u201340 years RR=1.9 (1.6\u20132.3).<\/jats:p>\n                  <jats:p>So far, it is questionable whether the introduction of LD\u2010TD\u2010BUP actually has stabilised opioids consumption or whether it has complicated and increased the consumption of potentially addictive drugs.<\/jats:p>","DOI":"10.1016\/j.ejpain.2008.11.005","type":"journal-article","created":{"date-parts":[[2008,12,18]],"date-time":"2008-12-18T05:43:22Z","timestamp":1229579002000},"page":"949-953","source":"Crossref","is-referenced-by-count":14,"title":["Introduction of low dose transdermal buprenorphine \u2013 Did it influence use of potentially addictive drugs in chronic non\u2010malignant pain patients?"],"prefix":"10.1002","volume":"13","author":[{"given":"Svetlana","family":"Skurtveit","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kari","family":"Furu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stein","family":"Kaasa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petter C.","family":"Borchgrevink","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,1,9]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"185","article-title":"Repeated dispensing of codeine is associated with high consumption of benzodiazepines","volume":"18","author":"Bachs L.","year":"2008","journal-title":"Nor J Epidemiol"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2007.03.028"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.307.6908.846"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(99)00209-2"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2007.02847.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1090-3801(02)00144-1"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpain.2005.06.009"},{"key":"e_1_2_6_9_1","first-page":"129","article-title":"Establishment of the nationwide Norwegian Prescription Database (NorPD) \u2013 new research possibilities in pharmacoepidemiology in Norway","volume":"18","author":"Furu K.","year":"2008","journal-title":"Nor J Epidemiol"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpain.2007.10.012"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpain.2006.08.004"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2004.07.005"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1155\/2003\/436716"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1090-3801(02)00143-X"},{"key":"e_1_2_6_15_1","unstructured":"Norwegian Medicines Agency.Bruk av opioider ved behandling av langvarige non\u2010maligne smertetilstander \u2010 en oppdatering. [Therapeutic recommendations: Use of opioids in treatment of non\u2010malignant pain \u2013 Un update]. <http:www.legemiddelverket.notemplatesInterPage_69246.aspx >;2008[accessed 10.05.08]."},{"key":"e_1_2_6_16_1","unstructured":"The Pain Society.Recommendations for the appropriate use of opioids for persistent non\u2010cancer pain. A consensus statement prepared on behalf of the Pain Society the Royal College of Anaesthetists the Royal College of General Practitioners and the royal College of Psychiatrists <http:www.britishpainsociety.orgopioids_doc_2004.pdf >2004[accessed 10.05.08]."},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.1304"},{"key":"e_1_2_6_18_1","first-page":"1","article-title":"Opioid guidelines in the management of chronic non\u2010cancer pain","volume":"9","author":"Trescot A.M.","year":"2006","journal-title":"Pain Physician"},{"key":"e_1_2_6_19_1","doi-asserted-by":"crossref","first-page":"49","DOI":"10.5055\/jom.2007.0038","article-title":"Buprenorphine: a unique opioid with broad clinical applications","volume":"3","author":"Vadivelu N.","year":"2007","journal-title":"J Opioid Manag"},{"key":"e_1_2_6_20_1","unstructured":"VilbergA..Norsk legemiddelh\u00e5ndbok [Norwegian pharmaceutical handbook]. <http:www.legemiddelhandboka.no>;2008[accessed 10\/05\/08]."},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4780120902"},{"key":"e_1_2_6_22_1","unstructured":"WHO Collaborating Centre for Drug Statistics Methodology. Norwegian Institute of Public Health.Guidelines for ATC classification and DDD assignment Oslo Norway;2005."},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwh090"}],"container-title":["European Journal of Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.ejpain.2008.11.005","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.ejpain.2008.11.005","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T04:27:09Z","timestamp":1697430429000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1016\/j.ejpain.2008.11.005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,10]]},"references-count":22,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2009,10]]}},"alternative-id":["10.1016\/j.ejpain.2008.11.005"],"URL":"https:\/\/doi.org\/10.1016\/j.ejpain.2008.11.005","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1207957.673055","asserted-by":"object"}]},"ISSN":["1090-3801","1532-2149"],"issn-type":[{"value":"1090-3801","type":"print"},{"value":"1532-2149","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,10]]}}}