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Crohn's disease therefore may be a suitable model for the identification of novel pain susceptibility genes. In order to confirm this observation and to elucidate the underlying molecular mechanisms, we investigated if higher opioid needs of CD patients are due to a general change in pain sensitivity. Quantitative sensory testing (QST) was applied to a subgroup of patients and polymorphisms in the \u03bc\u2010opioid receptor (<jats:italic>OPRM1<\/jats:italic>) and catechol\u2010O\u2010methyltransferase (<jats:italic>COMT<\/jats:italic>) were investigated. Significantly increased post operative opioid requirements in CD patients were confirmed and QST assessment demonstrates that CD patients do not display increased pain sensitivity in terms of lowered thresholds to thermal and mechanical stimuli. The data also suggest that common variants in<jats:italic>OPRM1<\/jats:italic>and specific \u2018high pain sensitivity\u2019<jats:italic>COMT<\/jats:italic>haplotypes may not be the cause of high opioid needs. The results indicate that a more complex pathway is involved in the greater post operative opioid demand in CD. Therefore the presence of other, as yet unknown, genes could modulate opioid requirements in CD patients.<\/jats:p>","DOI":"10.1016\/j.ejpain.2008.12.004","type":"journal-article","created":{"date-parts":[[2009,1,23]],"date-time":"2009-01-23T10:11:59Z","timestamp":1232705519000},"page":"1036-1042","source":"Crossref","is-referenced-by-count":24,"title":["High post surgical opioid requirements in Crohn's disease are not due to a general change in pain sensitivity"],"prefix":"10.1002","volume":"13","author":[{"given":"Kathrin","family":"Huehne","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Leis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tino","family":"Muenster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Wehrfritz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Winter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Maih\u00f6fner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Foertsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Croner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Reis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Winterpacht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd","family":"Rautenstrauss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,1,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910708601209"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(01)00438-9"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2005.05.030"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2006.05.030"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0404.2000.101004262x.\/"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.16.9608"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(93)90117-8"},{"key":"e_1_2_6_9_1","doi-asserted-by":"crossref","unstructured":"CampaD GioiaA TomeiA PoliP BaraleR.Association of ABCB1\/MDR1 and OPRM1 gene polymorphisms with morphine pain relief.Clin Pharmacol Ther; Sep 26 2007[Epub ahead of print].","DOI":"10.1038\/sj.clpt.6100385"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clpt.2006.01.007"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddi013"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2007.09.004"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.03.082"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2006.03261.x"},{"key":"e_1_2_6_15_1","first-page":"1","article-title":"Inflammation affects sufentanil consumption in ulcerative colitis","volume":"25","author":"Fleyfel M.","year":"2007","journal-title":"Eur J Anaesthesiol"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2007.05.004"},{"key":"e_1_2_6_17_1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1111\/j.1365-2044.1989.tb11224.x","article-title":"Alfentanil requirement in Crohn's disease. 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