{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T13:01:59Z","timestamp":1773752519445,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,1,16]],"date-time":"2012-01-16T00:00:00Z","timestamp":1326672000000},"content-version":"vor","delay-in-days":625,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2010,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Background:<\/jats:italic> Instillation of local anesthetics into a surgical site has been gaining popularity in post\u2010operative pain management.<\/jats:p><jats:p><jats:italic>Aim:<\/jats:italic> To determine whether continuous intra\u2010articular infusion of bupivacaine via pain\u2010control infusion pumps (PCIP) enhances and sustains analgesia after total hip arthroplasty (THA).<\/jats:p><jats:p><jats:italic>Methods:<\/jats:italic> Ninety\u2010two patients undergoing THA were randomized to receive continuous intra\u2010articular infusion of either 0.5% bupivacaine or 0.9% normal saline at a flow rate of 2 mL\/h via a PCIP for 48 h. The primary outcome measure was pain intensity on Visual Analogue Scale (VAS) scores in the first 72 h. Other measures included time to first rescue dose of narcotics, amount of narcotic use, presence of adverse events, length of hospital stay, and hip function evaluated with the Western Ontario and McMaster Universities Osteoarthritis (WOMAC) index.<\/jats:p><jats:p><jats:italic>Results:<\/jats:italic> Despite a longer time to first narcotic rescue (56 versus 21 min, <jats:italic>p<\/jats:italic> &lt; 0.0001) in patients receiving bupivacaine, the two groups did not differ significantly in overall pain relief (<jats:italic>p<\/jats:italic> = 0.54). A lower VAS score was found only at time 0 and 2 h; no difference in VAS score was noted at any other time point. Additionally, no difference was found in terms of amount of narcotic use, incidence of adverse events, hospitalization days, and the WOMAC score.<\/jats:p><jats:p><jats:italic>Conclusion:<\/jats:italic> Continuous intra\u2010articular infusion of 0.5% bupivacaine at 2 mL\/h via a PCIP does not provide sustained post\u2010operative pain relief in patients undergoing THA.<\/jats:p>","DOI":"10.1016\/j.ejpain.2009.08.008","type":"journal-article","created":{"date-parts":[[2009,9,25]],"date-time":"2009-09-25T16:43:37Z","timestamp":1253897017000},"page":"529-534","source":"Crossref","is-referenced-by-count":26,"title":["Continuous intra\u2010articular infusion of bupivacaine for post\u2010operative pain relief after total hip arthroplasty: A randomized, placebo\u2010controlled, double\u2010blind study"],"prefix":"10.1002","volume":"14","author":[{"given":"Dave 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