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Chronic constriction injury to the infraorbital nerve (ION\u2010CCI) by loose ligatures has proven a useful model for some types of trigeminal neuropathic pain disorder. Using ION\u2010CCI rats, we examined the antiallodynic effects of intrathecally administered agents which are selective for 5\u2010HT2C receptors. Allodynia was evaluated by applying von Frey filaments to skin innervated by the injured ION. Dose\u2010dependent antiallodynic effects followed administration of three 5\u2010HT2C receptor agonists, 6\u2010chloro\u20102\u2010(1\u2010piperazinyl)\u2010pyrazine (MK212: 10, 30, and 100 \u03bcg); (S)\u20102\u2010(chloro\u20105\u2010fluoro\u2010indol\u2010l\u2010yl)\u20101\u2010methyamine fumarate (RO 60\u20100175: 10, 30, and 100 \u03bcg); (AaR)\u20108,9\u2010dichloro\u20102,3,4,4a\u2010tetrahydro\u20101H\u2010pyrazino[1,2\u2010a]quinoxalin\u20105(6H)\u2010one (WAY\u2010161503: 10, 30, and 100 \u03bcg). ED50 values for antiallodynic effects of MK212, RO 60\u20100175, and WAY\u2010161503 were 39.62, 46.67, and 51.22 \u03bcg, respectively. Intrathecal administration of the 5\u2010HT2C receptor antagonist, 8\u2010[5\u20102,4\u2010dimethoxy\u20105\u2010(4\u2010trifluoromethylphenylsulphonamido)phenyl\u20105\u2010oxopentyl]\u20101,3,8\u2010triazaspiro[4,5]decane\u20102,4\u2010dione (RS\u2010102221: 30 \u03bcg) did not alter the mechanical threshold. Intrathecal pretreatment with RS\u2010102221 (10 and 30 \u03bcg) reduced the antiallodynic effects of the highest dose of 5\u2010HT2C agonists. These results indicated that, in this rat model, the 5\u2010HT2C receptor plays a role in spinal inhibition of trigeminal neuropathic pain.<\/jats:p>","DOI":"10.1016\/j.ejpain.2010.04.008","type":"journal-article","created":{"date-parts":[[2010,5,22]],"date-time":"2010-05-22T05:08:40Z","timestamp":1274504920000},"page":"999-1006","source":"Crossref","is-referenced-by-count":35,"title":["5\u2010HT2C receptor agonists attenuate pain\u2010related behaviour in a rat model of trigeminal neuropathic 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