{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T23:27:36Z","timestamp":1789946856685,"version":"4.0.1"},"reference-count":55,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,1,13]],"date-time":"2012-01-13T00:00:00Z","timestamp":1326412800000},"content-version":"vor","delay-in-days":134,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Chronic pain is a hallmark of osteoarthritis (OA), yet little is known about its properties and representation in the brain. Here we use fMRI combined with psychophysics to study knee pain in fourteen OA patients and nine healthy controls. Mechanical painful pressure stimuli were applied to the knee in both groups and ratings of evoked pain and related brain activity examined. We observe that psychophysical properties and brain activation patterns of evoked pain are essentially the same between OA patients and healthy subjects, and between worse and better OA knees. In OA patients, stimulus\u2010related brain activity could be distinguished from brain activity associated with spontaneous pain. The former activated brain regions commonly observed for acute painful stimuli in healthy subjects, while the spontaneous pain of OA engaged prefrontal\u2010limbic regions closely corresponding to areas observed for spontaneous pain in other chronic pain conditions, such as chronic back pain and post\u2010herpetic neuralgia. Arthritis\u2010related clinical characteristics of knee OA also mapped to prefrontal\u2010limbic regions. In a subgroup of patients (<jats:italic>n<\/jats:italic> =6) we examined brain activity changes for a 2\u2010week, repeat measure, cyclooxygenase\u20102 inhibitor (valdecoxib) therapy. Treatment decreased spontaneous pain for the worse knee and clinical characteristics of OA, and increased blood and csf levels of the drug which correlated positively with prefrontal\u2010limbic brain activity. These findings indicate dissociation between mechanically induced and spontaneous OA knee pain, the latter engaging brain regions involved in emotional assessment of the self, and challenge the standard clinical view regarding the nature of OA pain.<\/jats:p>","DOI":"10.1016\/j.ejpain.2010.12.007","type":"journal-article","created":{"date-parts":[[2011,2,11]],"date-time":"2011-02-11T09:39:54Z","timestamp":1297417194000},"source":"Crossref","is-referenced-by-count":40,"title":["Brain activity for chronic knee osteoarthritis: Dissociating evoked pain from spontaneous pain"],"prefix":"10.1002","volume":"15","author":[{"given":"Elle L.","family":"Parksl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul Y.","family":"Gehal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marwan N.","family":"Balikil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Katzl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"Schnitzerl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Vania","family":"Apkarianl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,1,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2003.12.015"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpain.2004.11.001"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2008.09.012"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3576-06.2006"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1744-8069-4-47"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.91100.2008"},{"key":"e_1_2_6_8_1","first-page":"2473","article-title":"WOMAC: a 20\u2010year experiential review of a patient\u2010centered self\u2010reported health status questionnaire","volume":"29","author":"Bellamy N.","year":"2002","journal-title":"J Rheumatol"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2009.06.014"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.3310\/hta12110"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/0470867639.ch13"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200502000-00026"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1076358"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2009.07.014"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-134-7-200104030-00007"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.bor.0000172800.49120.97"},{"key":"e_1_2_6_17_1","first-page":"449","volume-title":"Proceedings of the 11th world congress on pain","author":"Fields H.L.","year":"2006"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.460020402"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1364-6613(02)00025-6"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2006.09.014"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.3109\/17453670209178029"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24837"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1526-5900(03)00557-1"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.067470"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-200111000-00053"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24120"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/0470869526.ch12"},{"key":"e_1_2_6_28_1","first-page":"159","article-title":"Is self\u2010reported improvement in osteoarthritis pain and disability reflected in objective measures?","volume":"34","author":"Johnson S.R.","year":"2007","journal-title":"J Rheumatol"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/0470867639.ch9"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22460"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0704428"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.3109\/03009749709065721"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ane.0000278091.29062.63"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(87)91074-8"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpain.2005.06.002"},{"key":"e_1_2_6_36_1","doi-asserted-by":"crossref","unstructured":"M.MillecampsM.V.CentenoH.H.BerraC.N.RudickS.LavarelloT.Tkatchet al.D\u2010cycloserine reduces neuropathic pain behavior through limbic NMDA\u2010mediated circuitry.Pain2006.","DOI":"10.1016\/j.pain.2007.03.003"},{"key":"e_1_2_6_37_1","first-page":"331","article-title":"Modifiers of change in physical functioning in older adults with knee pain: the Observational Arthritis Study in Seniors (OASIS)","volume":"45","author":"Miller M.E.","year":"2001","journal-title":"Rheum"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/1744-8069-3-8"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.57.10.588"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/0470867639.ch8"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2004.08.042"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4637.2008.00498.x"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/35068566"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-009-1782-9"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2008.05.020"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.23241"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.bor.0000209426.84775.f8"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0736-0266(00)90024-X"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.2522\/ptj.20060301"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2005.06.058"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11096-009-9312-1"},{"key":"e_1_2_6_52_1","first-page":"287","article-title":"COX2 in CNS neural cells mediates mechanical inflammatory pain hypersensitivity in mice","volume":"119","author":"Vardeh D.","year":"2009","journal-title":"J Clin Invest"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0b013e31816b1058"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0702413104"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.0931"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2003.12.023"}],"container-title":["European Journal of Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.ejpain.2010.12.007","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.ejpain.2010.12.007","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.ejpain.2010.12.007","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.ejpain.2010.12.007","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.ejpain.2010.12.007","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T04:31:19Z","timestamp":1693801879000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1016\/j.ejpain.2010.12.007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9]]},"references-count":55,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2011,9]]}},"alternative-id":["10.1016\/j.ejpain.2010.12.007"],"URL":"https:\/\/doi.org\/10.1016\/j.ejpain.2010.12.007","archive":["Portico"],"relation":{},"ISSN":["1090-3801","1532-2149"],"issn-type":[{"value":"1090-3801","type":"print"},{"value":"1532-2149","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,9]]}}}