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Since it has been hypothesized that cytokines play an etiopathogenic role in fibromyalgia and other chronic widespread pain conditions, we investigated the relationship between stress and cytokines in a model of stress\u2010induced chronic somatic pain. A series of experiments were performed to evaluate the impact of stress on the hyperalgesia\u2010induced by endotoxin (lipopolysaccharide, LPS) and the role of two pro\u2010inflammatory cytokines, interleukin\u20106 (IL\u20106) and tumor necrosis \u03b1 (TNF\u03b1). Fourteen days after exposure to a 4\u2010day protocol of unpredictable sound stress, the ability of systemic LPS (100\u03bcg\/kg, i.p) to elicit cytokine\u2010mediated mechanical hyperalgesia was measured in gastrocnemius muscle. LPS\u2010induced hyperalgesia was significantly greater in stressed rats, but when rats were treated intrathecally with antisense oligodeoxynucleotide (ODN), to decrease either the gp130 subunit of the IL\u20106 receptor or the TNF\u03b1 receptor, in nociceptors, skeletal muscle hyperalgesia in sound stressed, but not control, rats was prevented. These data suggest that chronic stress alters signaling in the primary afferent nociceptor for the hyperalgesia induced by endogenously produced pro\u2010inflammatory cytokines.<\/jats:p>","DOI":"10.1016\/j.ejpain.2011.02.005","type":"journal-article","created":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T04:57:02Z","timestamp":1314853022000},"page":"796-800","source":"Crossref","is-referenced-by-count":37,"title":["Enhanced cytokine\u2010induced mechanical hyperalgesia in skeletal muscle produced by a novel mechanism in rats exposed to unpredictable sound stress"],"prefix":"10.1002","volume":"15","author":[{"given":"Olayinka A.","family":"Dinal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jon D.","family":"Levinel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul 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