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Here, we examined the effects of intrathecal <jats:styled-content style=\"fixed-case\">lipoxinA4<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">LXA4<\/jats:styled-content>) on <jats:styled-content style=\"fixed-case\">NF\u2010\u03baB<\/jats:styled-content> activation and pro\u2010inflammatory cytokine (<jats:styled-content style=\"fixed-case\">TNF\u2010\u03b1<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">IL\u20101\u03b2<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">IL\u20106<\/jats:styled-content>) expression in dorsal root ganglia (<jats:styled-content style=\"fixed-case\">DRG<\/jats:styled-content>) following chronic compression of <jats:styled-content style=\"fixed-case\">DRG<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">CCD<\/jats:styled-content>), a model of neuropathic pain. Daily intrathecal injection of vehicle or <jats:styled-content style=\"fixed-case\">LXA4<\/jats:styled-content> (10\u2009ng or 100\u2009ng) was performed for three successive days post\u2010<jats:styled-content style=\"fixed-case\">CCD<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">CCD<\/jats:styled-content> induced both mechanical allodynia and thermal hyperalgesia, and increased the expression of <jats:styled-content style=\"fixed-case\">TNF\u2010\u03b1<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">IL\u20101\u03b2<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">IL\u20106<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">NF\u2010\u03baB<\/jats:styled-content>. Intrathecal injection of <jats:styled-content style=\"fixed-case\">LXA4<\/jats:styled-content> prevented the development of neuropathic pain and inhibited <jats:styled-content style=\"fixed-case\">NF\u2010\u03baB<\/jats:styled-content> activation and pro\u2010inflammatory cytokine upregulation in a dose\u2010dependent manner. In this study, we have shown the strong protective effect of intrathecal <jats:styled-content style=\"fixed-case\">LXA4<\/jats:styled-content> on the development of nociceptive behaviors induced by <jats:styled-content style=\"fixed-case\">CCD<\/jats:styled-content> and that these effects might be associated with its anti\u2010inflammatory and pro\u2010resolution properties.<\/jats:p>","DOI":"10.1016\/j.ejpain.2011.05.005","type":"journal-article","created":{"date-parts":[[2011,6,16]],"date-time":"2011-06-16T22:27:35Z","timestamp":1308263255000},"page":"18-27","source":"Crossref","is-referenced-by-count":33,"title":["<scp>LipoxinA<sub>4<\/sub><\/scp> induced antinociception and decreased expression of <scp>NF\u2010\u03baB<\/scp> and pro\u2010inflammatory cytokines after chronic dorsal root ganglia compression in rats"],"prefix":"10.1002","volume":"16","author":[{"given":"T.","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Pain Management Provincial Hospital 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