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As previous studies included patients with shoulder\/arm symptoms or neck pain, a potential influence of these coexisting disorders cannot be excluded. This study therefore evaluated whether widespread sensory changes (hypoesthesia or hyperalgesia) are present in patients with unilateral <jats:styled-content style=\"fixed-case\">CTS<\/jats:styled-content> in the absence of coexisting disorders. Twenty\u2010six patients with unilateral <jats:styled-content style=\"fixed-case\">CTS<\/jats:styled-content> with symptoms localised to their hand and 26 healthy controls participated in the study. A comprehensive quantitative sensory testing (<jats:styled-content style=\"fixed-case\">QST<\/jats:styled-content>) protocol including thermal and mechanical detection and pain thresholds was performed over the hands (median, ulnar and radial innervation area), lateral elbows, neck and tibialis anterior muscle. Patients with <jats:styled-content style=\"fixed-case\">CTS<\/jats:styled-content> demonstrated thermal and mechanical hypoesthesia in the hand but not at distant sites. Thermal or mechanical hyperalgesia was not identified at any location with traditional <jats:styled-content style=\"fixed-case\">QST<\/jats:styled-content> threshold testing. However, patients with <jats:styled-content style=\"fixed-case\">CTS<\/jats:styled-content> rated the pain during thermal pain testing significantly higher than healthy participants. This was especially apparent for heat pain ratings which were elevated not only in the affected hand but also in the neck and tibialis anterior muscle. In conclusion, <jats:styled-content style=\"fixed-case\">CTS<\/jats:styled-content> alone in the absence of coexisting neck and arm pain does not account for sensory changes outside the affected hand as determined by traditional <jats:styled-content style=\"fixed-case\">QST<\/jats:styled-content> threshold testing. Elevated pain ratings may however be an early indication of central pain mechanisms.<\/jats:p>","DOI":"10.1016\/j.ejpain.2011.06.003","type":"journal-article","created":{"date-parts":[[2011,6,28]],"date-time":"2011-06-28T17:22:44Z","timestamp":1309281764000},"page":"217-228","source":"Crossref","is-referenced-by-count":25,"title":["Can widespread hypersensitivity in carpal tunnel syndrome be substantiated if neck and arm pain are absent?"],"prefix":"10.1002","volume":"16","author":[{"given":"A.B.","family":"Schmid","sequence":"first","affiliation":[{"name":"Centre of Clinical Research Excellence in Spinal Pain Injury and Health, Division of Physiotherapy School of Health and Rehabilitation Sciences The University of Queensland  St. Lucia Brisbane QLD 4072 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.TC.","family":"Soon","sequence":"additional","affiliation":[{"name":"Centre of Clinical Research Excellence in Spinal Pain Injury and Health, Division of 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