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We previously demonstrated that both neurotensin (<jats:styled-content style=\"fixed-case\">NT<\/jats:styled-content>) receptor subtypes 1 (<jats:styled-content style=\"fixed-case\">NTS<\/jats:styled-content>1) and 2 (<jats:styled-content style=\"fixed-case\">NTS<\/jats:styled-content>2) are involved in mediating the naloxone\u2010insensitive antinociceptive effects of neurotensin in different analgesic tests including hotplate, tail\u2010flick, and tonic pain. However, the role of these receptors in neuropathic pain management has been poorly investigated. In the present study, we therefore examined whether intrathecal delivery of<jats:styled-content style=\"fixed-case\">NTS<\/jats:styled-content>1 agonists was effective in reducing neuropathic pain symptoms in rats. Neuropathy was induced by sciatic nerve constriction (<jats:styled-content style=\"fixed-case\">CCI<\/jats:styled-content>model), and the development of mechanical allodynia and thermal hyperalgesia on the ipsi\u2010 and contralateral hind paws was examined 3, 7, 14, 21, and 28 days post\u2010surgery.<jats:styled-content style=\"fixed-case\">CCI<\/jats:styled-content>\u2010operated rats exhibited significant increases in thermal and mechanical hypersensitivities over a 28\u2010day testing period. Spinal injection of<jats:styled-content style=\"fixed-case\">NT<\/jats:styled-content>to<jats:styled-content style=\"fixed-case\">CCI<\/jats:styled-content>rats alleviated the behavioral responses to radiant heat and mechanical stimuli, with a maximal reversal of 91% of allodynia at 6\u2009\u03bcg\/kg. Intrathecal administration of the<jats:styled-content style=\"fixed-case\">NTS<\/jats:styled-content>1\u2010selective agonist,<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>149163 (30\u201390\u2009\u03bcg\/kg) also produced potent anti\u2010allodynic and anti\u2010hyperalgesic effects in nerve\u2010injured rats. Likewise, heat hyperalgesia and tactile allodynia produced by<jats:styled-content style=\"fixed-case\">CCI<\/jats:styled-content>of the sciatic nerve were fully reversed by the<jats:styled-content style=\"fixed-case\">NTS<\/jats:styled-content>1 agonist,<jats:styled-content style=\"fixed-case\">NT<\/jats:styled-content>69<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>(5\u201325\u2009\u03bcg\/kg). Altogether, these results support the idea that the<jats:styled-content style=\"fixed-case\">NTS<\/jats:styled-content>1 receptor subtype is involved in pain modulation, and the potential use of<jats:styled-content style=\"fixed-case\">NTS<\/jats:styled-content>1 agonists for the treatment of painful neuropathies.<\/jats:p>","DOI":"10.1016\/j.ejpain.2011.07.008","type":"journal-article","created":{"date-parts":[[2011,8,21]],"date-time":"2011-08-21T17:05:23Z","timestamp":1313946323000},"page":"473-484","source":"Crossref","is-referenced-by-count":46,"title":["Intrathecal administration of<scp>NTS<\/scp>1 agonists reverses nociceptive behaviors in a rat model of neuropathic pain"],"prefix":"10.1002","volume":"16","author":[{"given":"A.","family":"Guillemette","sequence":"first","affiliation":[{"name":"Department of Physiology and Biophysics Faculty of Medicine and Health Sciences Universit\u00e9 de Sherbrooke Sherbrooke Quebec 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