{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:50:02Z","timestamp":1788871802502,"version":"build-2803163510"},"reference-count":44,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,3,6]],"date-time":"2012-03-06T00:00:00Z","timestamp":1330992000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"crossref","award":["R01DA018417"],"award-info":[{"award-number":["R01DA018417"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Increased pain sensitivity and the development of opioid tolerance complicate the treatment of pain experiencedby opioid maintained pregnantwomenduring delivery and the perinatal period. Theaim of the present study was to investigate differences in pain management of opioid maintained compared to nondependent pregnant women during delivery and the postpartum period. 40 deliveries of 37 opioid dependent women enrolled in a double\u2010blind, double\u2010dummy randomized controlled trial (\n                    <jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content>\n                    ) examining the safety and efficacy of methadone (mean dose at the time of delivery\u2009=\u200963.89\u2009mg) and buprenorphine (mean dose at the time of delivery\u2009=\u200914.05\u2009mg) during pregnancy were analyzed and participants were matched to a non\u2010dependent comparison group of 80 pregnant women. Differences in pain management (opioid and non\u2010opioid analgesic medication) during delivery and perinatal period were analyzed. Following cesarean delivery opioid maintained women received significantly less opioid analgesics (day of delivery\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.038; day 1:\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.02),\n                    <jats:styled-content style=\"fixed-case\">NSAIDs<\/jats:styled-content>\n                    were administered more frequently to opioid dependent patients than to the comparison group during cesarean section and on the third day postpartum. Significantly higher nicotine consumption in the group of opioid dependentwomenhad a strong influence onthe retrieved results, and might be considered as an independent factor of altered pain experience. Differences in pain treatment became evident when comparing opioid maintained women to healthy controls. These differences might be based on psychosocial consequences of opioid addiction along with the lack of an interdisciplinary consensus on pain treatment protocols for opioid dependent patients.\n                  <\/jats:p>","DOI":"10.1016\/j.ejpain.2011.08.008","type":"journal-article","created":{"date-parts":[[2011,9,18]],"date-time":"2011-09-18T00:40:24Z","timestamp":1316306424000},"page":"574-584","source":"Crossref","is-referenced-by-count":45,"title":["Peripartum pain management in opioid dependent women"],"prefix":"10.1002","volume":"16","author":[{"given":"A.S.","family":"H\u00f6flich","sequence":"first","affiliation":[{"name":"Medical University Vienna Department of Psychiatry and Psychotherapy  W\u00e4hringer G\u00fcrtel 18\u201320 1090 Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Langer","sequence":"additional","affiliation":[{"name":"Medical University of Vienna Department of Gynaecology Division of Obstetrics and Feto\u2010Maternal Medicine  W\u00e4hringer G\u00fcrtel 18\u201320 1090 Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Jagsch","sequence":"additional","affiliation":[{"name":"University of Vienna Department of Clinical Biological and Differential Psychology  Universit\u00e4tsstra\u00dfe 7 1010 Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"B\u00e4wert","sequence":"additional","affiliation":[{"name":"Medical University Vienna Department of Psychiatry and Psychotherapy  W\u00e4hringer G\u00fcrtel 18\u201320 1090 Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Winklbaur","sequence":"additional","affiliation":[{"name":"Medical University Vienna Department of Psychiatry and Psychotherapy  W\u00e4hringer G\u00fcrtel 18\u201320 1090 Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Fischer","sequence":"additional","affiliation":[{"name":"Medical University Vienna Department of Psychiatry and Psychotherapy  W\u00e4hringer G\u00fcrtel 18\u201320 1090 Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Unger","sequence":"additional","affiliation":[{"name":"Medical University Vienna Department of Psychiatry and Psychotherapy  W\u00e4hringer G\u00fcrtel 18\u201320 1090 Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,3,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-144-2-200601170-00010"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2004.05.020"},{"key":"e_1_2_8_4_1","doi-asserted-by":"crossref","unstructured":"Austrian Ministry of Health.Women health report 2010\/2011;2011. p.239\u2013240.","DOI":"10.1016\/S0084-3970(10)79303-8"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-8180(03)00058-8"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2006.01651.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00115550-200411000-00011"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0310057X0403200406"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0376-8716(00)00200-3"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1D580"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(01)00306-2"},{"key":"e_1_2_8_12_1","unstructured":"EMCDDA.Drug use and pregnancy challenges for public health. 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