{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T10:51:05Z","timestamp":1789901465098,"version":"4.0.1"},"reference-count":20,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"published-print":{"date-parts":[[2009,2]]},"DOI":"10.1016\/j.ejpb.2008.10.001","type":"journal-article","created":{"date-parts":[[2008,10,13]],"date-time":"2008-10-13T06:15:49Z","timestamp":1223878549000},"page":"362-366","source":"Crossref","is-referenced-by-count":29,"title":["Dermatopharmacokinetics of betamethasone 17-valerate: Influence of formulation viscosity and skin surface cleaning procedure"],"prefix":"10.1016","volume":"71","author":[{"given":"Sandra","family":"Wiedersberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia S.","family":"Leopold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard H.","family":"Guy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejpb.2008.10.001_bib1","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1023\/A:1014866001386","article-title":"Chemical uptake into human stratum corneum in vivo from volatile and non-volatile solvents","volume":"16","author":"Stinchcomb","year":"1999","journal-title":"Pharm. Res."},{"key":"10.1016\/j.ejpb.2008.10.001_bib2","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0378-5173(99)00217-3","article-title":"Distribution of salicylic acid in human stratum corneum following topical application in vivo: a comparison of six different formulations","volume":"188","author":"Tsai","year":"1999","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2008.10.001_bib3","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1023\/A:1018975626210","article-title":"Feasibility of measuring the bioavailability of topical betamethasone dipropionate in commercial formulations using drug content in skin and a skin blanching assay","volume":"9","author":"Pershing","year":"1992","journal-title":"Pharm. Res."},{"key":"10.1016\/j.ejpb.2008.10.001_bib4","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1023\/A:1011941929495","article-title":"Bioequivalence of topical dermatological dosage forms-methods of evaluation of bioequivalence","volume":"15","author":"Shah","year":"1998","journal-title":"Pharm. Res."},{"key":"10.1016\/j.ejpb.2008.10.001_bib5","unstructured":"FDA, Guidance for Industry: Topical dermatologic drug product NDAs and ANDAs-in vivo bioavailability, bioequivalence, in vitro release, and associated studies, Draft Guidance, U.S. Department of Health and Human Services, Food and Drug Administration, Center of Drug Evaluation and Research, 1998."},{"key":"10.1016\/j.ejpb.2008.10.001_bib6","unstructured":"FDA, Guidance for Industry on special protocol assessment; Availability, Fed. Reg. 67: 35122, U.S. Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research, 2002."},{"key":"10.1016\/j.ejpb.2008.10.001_bib7","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1159\/000211355","article-title":"Texture analysis of the surface of the human skin","volume":"8","author":"Fiedler","year":"1995","journal-title":"Skin Pharmacol."},{"key":"10.1016\/j.ejpb.2008.10.001_bib8","article-title":"Pharmacodynamics and dermatopharmacokinetics of betamethasone 17-valerate: assessment of topical bioavailability","author":"Wiedersberg","year":"2008","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.ejpb.2008.10.001_bib9","doi-asserted-by":"crossref","first-page":"2692","DOI":"10.1016\/S0006-3495(96)79460-2","article-title":"Homogeneous transport in a heterogeneous membrane: water diffusion across human stratum corneum in vivo","volume":"71","author":"Kalia","year":"1996","journal-title":"Biophys. J."},{"key":"10.1016\/j.ejpb.2008.10.001_bib10","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/1523-1747.ep12674117","article-title":"Variations in physical dimensions and chemical composition of human stratum corneum","volume":"61","author":"Anderson","year":"1973","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.ejpb.2008.10.001_bib11","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1023\/A:1026474200575","article-title":"Normalization of stratum corneum barrier function and transepidermal water loss in vivo","volume":"17","author":"Kalia","year":"2000","journal-title":"Pharm. Res."},{"key":"10.1016\/j.ejpb.2008.10.001_bib12","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1159\/000056394","article-title":"Assessment of topical bioavailability in vivo: the importance of stratum corneum thickness","volume":"14","author":"Kalia","year":"2001","journal-title":"Skin Pharmacol. Appl. Skin Physiol."},{"key":"10.1016\/j.ejpb.2008.10.001_bib13","series-title":"The Mathematics of Diffusion","first-page":"44","article-title":"Diffusion in a plane sheet","author":"Crank","year":"1975"},{"key":"10.1016\/j.ejpb.2008.10.001_bib14","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1007\/s004030050232","article-title":"Tape stripping of human stratum corneum yields cell layers that originate from various depths because of furrows in the skin","volume":"289","author":"van der Molen","year":"1997","journal-title":"Arch. Dermatol. Res."},{"key":"10.1016\/j.ejpb.2008.10.001_bib15","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1034\/j.1600-0846.2001.007001040.x","article-title":"Physical and physiological effects of stratum corneum tape stripping","volume":"7","author":"Bashir","year":"2001","journal-title":"Skin Res. Technol."},{"key":"10.1016\/j.ejpb.2008.10.001_bib16","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1046\/j.1439-0353.2003.03733.x","article-title":"Effect of the vehicle on the amount of stratum corneum removed by tape stripping","volume":"1","author":"Jacobi","year":"2003","journal-title":"JDDG"},{"key":"10.1016\/j.ejpb.2008.10.001_bib17","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1002\/jps.20829","article-title":"Effect of propylene glycol on ibuprofen absorption into human skin in vivo","volume":"97","author":"Herkenne","year":"2008","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2008.10.001_bib18","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1007\/s11095-006-9011-8","article-title":"Pig ear skin ex vivo as a model for in vivo dermatopharmacokinetic studies in man","volume":"23","author":"Herkenne","year":"2006","journal-title":"Pharm. Res."},{"key":"10.1016\/j.ejpb.2008.10.001_bib19","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1023\/A:1012217209228","article-title":"Assessment and prediction of the cutaneous bioavailability of topical terbinafine, in vivo, in man","volume":"18","author":"Alberti","year":"2001","journal-title":"Pharm. Res."},{"key":"10.1016\/j.ejpb.2008.10.001_bib20","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1038\/sj.jid.5700642","article-title":"Dermatopharmacokinetic prediction of topical drug bioavailability in vivo","volume":"127","author":"Herkenne","year":"2007","journal-title":"J. Invest. Dermatol."}],"container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641108003858?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641108003858?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,25]],"date-time":"2018-12-25T04:59:00Z","timestamp":1545713940000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0939641108003858"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,2]]}},"alternative-id":["S0939641108003858"],"URL":"https:\/\/doi.org\/10.1016\/j.ejpb.2008.10.001","relation":{},"ISSN":["0939-6411"],"issn-type":[{"value":"0939-6411","type":"print"}],"subject":[],"published":{"date-parts":[[2009,2]]}}}