{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:54:59Z","timestamp":1791392099450,"version":"4.3.3"},"reference-count":34,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T00:00:00Z","timestamp":1283299200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"published-print":{"date-parts":[[2010,9]]},"DOI":"10.1016\/j.ejpb.2010.05.013","type":"journal-article","created":{"date-parts":[[2010,6,10]],"date-time":"2010-06-10T09:02:24Z","timestamp":1276160544000},"page":"120-126","source":"Crossref","is-referenced-by-count":26,"title":["Bisphosphonate protonation states, conformations, and dynamics on bone mineral probed by solid-state NMR without isotope enrichment"],"prefix":"10.1016","volume":"76","author":[{"given":"Matthew S.","family":"Ironside","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melinda J.","family":"Duer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David G.","family":"Reid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Byard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejpb.2010.05.013_bib1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1196\/annals.1402.089","article-title":"Bisphosphonates: an update on mechanisms of action and how these relate to clinical efficacy","volume":"1117","author":"Russell","year":"2007","journal-title":"Ann. NY Acad. Sci."},{"key":"10.1016\/j.ejpb.2010.05.013_bib2","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1039\/B512310K","article-title":"\u2018Magic bullets\u2019 for bone diseases: progress in rational design of bone-seeking medicinal agents","volume":"36","author":"Zhang","year":"2007","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.ejpb.2010.05.013_bib3","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1006\/bbrc.1999.1499","article-title":"Farnesyl pyrophosphate synthase is the molecular target of nitrogen-containing bisphosphonates","volume":"264","author":"van Beek","year":"1999","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejpb.2010.05.013_bib4","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1006\/bbrc.1999.0224","article-title":"Nitrogen-containing bisphosphonates inhibit isopentenyl pyrophosphate isomerase\/farnesyl pyrophosphate synthase activity with relative potencies corresponding to their antiresorptive potencies in vitro and in vivo","volume":"255","author":"van Beek","year":"1999","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejpb.2010.05.013_bib5","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0022-3565(24)38786-5","article-title":"Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates","volume":"296","author":"Dunford","year":"2001","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejpb.2010.05.013_bib6","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1007\/s00198-007-0540-8","article-title":"Mechanisms of action of bisphosphonates: similarities and differences and their potential influence on clinical efficacy","volume":"19","author":"Russell","year":"2008","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.ejpb.2010.05.013_bib7","doi-asserted-by":"crossref","first-page":"5171","DOI":"10.1021\/jm0302344","article-title":"3-D QSAR investigations of the inhibition of Leishmania major farnesyl pyrophosphate synthase by bisphosphonates","volume":"46","author":"Sanders","year":"2003","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejpb.2010.05.013_bib8","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1172\/JCI6800","article-title":"Prevention of osteocyte and osteoblast apoptosis by bisphosphonates and calcitonin","volume":"104","author":"Plotkin","year":"1999","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ejpb.2010.05.013_bib9","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.bone.2006.02.060","article-title":"Dissociation of the pro-apoptotic effects of bisphosphonates on osteoclasts from their anti-apoptotic effects on osteoblasts\/osteocytes with novel analogs","volume":"39","author":"Plotkin","year":"2006","journal-title":"Bone"},{"key":"10.1016\/j.ejpb.2010.05.013_bib10","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S8756-3282(98)00120-3","article-title":"Binding and antiresorptive properties of heterocycle-containing bisphosphonate analogs: structure\u2013activity relationships","volume":"23","author":"van Beek","year":"1998","journal-title":"Bone"},{"key":"10.1016\/j.ejpb.2010.05.013_bib11","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.bone.2005.05.003","article-title":"Novel insights into actions of bisphosphonates on bone: differences in interactions with hydroxyapatite","volume":"38","author":"Nancollas","year":"2006","journal-title":"Bone"},{"key":"10.1016\/j.ejpb.2010.05.013_bib12","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1002\/(SICI)1097-458X(200001)38:1<11::AID-MRC597>3.0.CO;2-V","article-title":"Solid-state NMR of bisphosphonates adsorbed on hydroxyapatite","volume":"38","author":"Grossmann","year":"2000","journal-title":"Magn. Reson. Chem."},{"key":"10.1016\/j.ejpb.2010.05.013_bib13","doi-asserted-by":"crossref","first-page":"8374","DOI":"10.1021\/ja902895p","article-title":"Thermodynamics of bisphosphonates binding to human bone: a two-site model","volume":"131","author":"Mukherjee","year":"2009","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.ejpb.2010.05.013_bib14","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1021\/ja0759949","article-title":"NMR investigations of the static and dynamic structures of bisphosphonates on human bone: a molecular model","volume":"130","author":"Mukherjee","year":"2008","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.ejpb.2010.05.013_bib15","doi-asserted-by":"crossref","first-page":"3372","DOI":"10.1016\/j.bpj.2008.12.3954","article-title":"The mineral phase of calcified cartilage: its molecular structure and interface with the organic matrix","volume":"96","author":"Duer","year":"2009","journal-title":"Biophys. J."},{"key":"10.1016\/j.ejpb.2010.05.013_bib16","doi-asserted-by":"crossref","first-page":"8804","DOI":"10.1007\/s10853-007-1916-z","article-title":"A solid state NMR comparison of the mineral structure in bone from diseased joints of the horse","volume":"42","author":"Maltsev","year":"2007","journal-title":"J. Mater. Sci."},{"key":"10.1016\/j.ejpb.2010.05.013_bib17","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1002\/jbmr.5650091206","article-title":"Structural requirements for bisphosphonate actions in vitro","volume":"9","author":"van Beek","year":"1994","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.ejpb.2010.05.013_bib18","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1002\/jbmr.5650111016","article-title":"Dissociation of binding and antiresorptive properties of hydroxybisphosphonates by substitution of the hydroxyl with an amino group","volume":"11","author":"Van Beek","year":"1996","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.ejpb.2010.05.013_bib19","doi-asserted-by":"crossref","first-page":"3721","DOI":"10.1021\/jm020819i","article-title":"Highly potent geminal bisphosphonates. From pamidronate disodium (Aredia) to zoledronic acid (Zometa)","volume":"45","author":"Widler","year":"2002","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejpb.2010.05.013_bib20","doi-asserted-by":"crossref","first-page":"14485","DOI":"10.1021\/ja061737c","article-title":"Solid-state NMR, crystallographic, and computational investigation of bisphosphonates and farnesyl diphosphate synthase\u2013bisphosphonate complexes","volume":"128","author":"Mao","year":"2006","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.ejpb.2010.05.013_bib21","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1126\/science.1078470","article-title":"Detection of hydroxyl ions in bone mineral by solid-state NMR spectroscopy","volume":"300","author":"Cho","year":"2003","journal-title":"Science (New York, NY)"},{"key":"10.1016\/j.ejpb.2010.05.013_bib22","first-page":"718","article-title":"Produits anti-inflammatoires d\u00e9riv\u00e9s de l\u2019acide m\u00e9thyl\u00e8ne diphosphonique et leur proc\u00e9d\u00e9 de pr\u00e9paration","volume":"100","author":"Breli\u00e8re","year":"1984","journal-title":"Eur. Pat. Appl. EP"},{"key":"10.1016\/j.ejpb.2010.05.013_bib23","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1002\/mrc.2262","article-title":"Correlating sideband patterns with powder patterns for accurate determination of chemical shift parameters in solid-state NMR","volume":"46","author":"Ironside","year":"2008","journal-title":"Magn. Reson. Chem."},{"key":"10.1016\/j.ejpb.2010.05.013_bib24","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1006\/jmre.2002.2520","article-title":"Cogwheel phase cycling","volume":"155","author":"Levitt","year":"2002","journal-title":"J. Magn. Reson."},{"key":"10.1016\/j.ejpb.2010.05.013_bib25","series-title":"Introduction to Solid-state NMR Spectroscopy","author":"Duer","year":"2004"},{"key":"10.1016\/j.ejpb.2010.05.013_bib26","doi-asserted-by":"crossref","first-page":"6021","DOI":"10.1063\/1.440136","article-title":"Sideband intensities in NMR spectra of samples spinning at the magic angle","volume":"73","author":"Herzfeld","year":"1980","journal-title":"J. Chem. Phys."},{"key":"10.1016\/j.ejpb.2010.05.013_bib27","doi-asserted-by":"crossref","first-page":"3300","DOI":"10.1063\/1.437915","article-title":"NMR in rotating solids","volume":"70","author":"Maricq","year":"1979","journal-title":"J. Chem. Phys."},{"key":"10.1016\/j.ejpb.2010.05.013_bib28","first-page":"172","article-title":"A novel method to determine the principal values of a chemical shift tensor from MAS NMR powder spectra","volume":"88","author":"Fenzke","year":"1990","journal-title":"J. Magn. Reson."},{"key":"10.1016\/j.ejpb.2010.05.013_bib29","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1006\/jmra.1996.0237","article-title":"Rigorous statistical analysis of errors in chemical-shift-tensor components obtained from spinning side bands in solid-state NMR","volume":"123","author":"Olivieri","year":"1996","journal-title":"J. Magn. Reson. Ser. A"},{"key":"10.1016\/j.ejpb.2010.05.013_bib30","first-page":"2198","article-title":"Monosodium 4-amino-1-hydroxy-1,1-butanediphosphonate trihydrate (Alendronate)","volume":"52","author":"Vega","year":"1996","journal-title":"Acta Crystallogr."},{"key":"10.1016\/j.ejpb.2010.05.013_bib31","first-page":"m77","article-title":"Disodium pamidronate","volume":"58","author":"Vega","year":"2002","journal-title":"Acta Crystallogr."},{"key":"10.1016\/j.ejpb.2010.05.013_bib32","first-page":"330","article-title":"Determination of C-N internuclear distances by rotational-echo double-resonance NMR in solids","volume":"90","author":"Pan","year":"1990","journal-title":"J. Magn. Reson."},{"key":"10.1016\/j.ejpb.2010.05.013_bib33","doi-asserted-by":"crossref","first-page":"9324","DOI":"10.1021\/jp056644g","article-title":"Homonuclear and heteronuclear NMR studies of a statherin fragment bound to hydroxyapatite crystals","volume":"110","author":"Raghunathan","year":"2006","journal-title":"J. Phys. Chem."},{"key":"10.1016\/j.ejpb.2010.05.013_bib34","first-page":"446","article-title":"Structure of 6-amino-1-hydroxyhexylidenebis(phosphonic acid)","volume":"45","author":"Coiro","year":"1989","journal-title":"Acta Crystallogr."}],"container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641110001529?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641110001529?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T21:37:38Z","timestamp":1740173858000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0939641110001529"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,9]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,9]]}},"alternative-id":["S0939641110001529"],"URL":"https:\/\/doi.org\/10.1016\/j.ejpb.2010.05.013","relation":{},"ISSN":["0939-6411"],"issn-type":[{"value":"0939-6411","type":"print"}],"subject":[],"published":{"date-parts":[[2010,9]]}}}