{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:41:31Z","timestamp":1791247291919,"version":"4.1.0"},"reference-count":52,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"published-print":{"date-parts":[[2011,10]]},"DOI":"10.1016\/j.ejpb.2011.04.017","type":"journal-article","created":{"date-parts":[[2011,5,9]],"date-time":"2011-05-09T22:55:37Z","timestamp":1304981737000},"page":"276-284","source":"Crossref","is-referenced-by-count":156,"title":["Paclitaxel loaded PEG5000\u2013DSPE micelles as pulmonary delivery platform: Formulation characterization, tissue distribution, plasma pharmacokinetics, and toxicological evaluation"],"prefix":"10.1016","volume":"79","author":[{"given":"Kanwaldeep K.","family":"Gill","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sami","family":"Nazzal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amal","family":"Kaddoumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejpb.2011.04.017_b0005","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.ejpb.2007.04.005","article-title":"Liposomes for drug delivery to the lungs by nebulization","volume":"67","author":"Zaru","year":"2007","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ejpb.2011.04.017_b0010","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.ejpb.2006.07.006","article-title":"Solid lipid microparticles as a sustained release system for pulmonary drug delivery","volume":"65","author":"Jaspart","year":"2007","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ejpb.2011.04.017_b0015","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.ejps.2005.04.009","article-title":"Microencapsulated chitosan nanoparticles for lung protein delivery","volume":"25","author":"Grenha","year":"2005","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2011.04.017_b0020","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1089\/089426804322994415","article-title":"Cyclosporin A aerosol improves the anticancer effect of paclitaxel aerosol in mice","volume":"17","author":"Koshkina","year":"2004","journal-title":"J. Aero. Med."},{"key":"10.1016\/j.ejpb.2011.04.017_b0025","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.tibtech.2007.09.005","article-title":"Nanoparticles for drug delivery to the lungs","volume":"12","author":"Sung","year":"2007","journal-title":"Trends Biotech."},{"key":"10.1016\/j.ejpb.2011.04.017_b0030","doi-asserted-by":"crossref","first-page":"4425","DOI":"10.1016\/S0142-9612(02)00182-5","article-title":"New polymeric carriers for controlled drug delivery following inhalation or injection","volume":"23","author":"Fu","year":"2002","journal-title":"Biomaterials"},{"key":"10.1016\/j.ejpb.2011.04.017_b0035","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1002\/med.20140","article-title":"Nanoparticle formulations in pulmonary drug delivery","volume":"29","author":"Bailey","year":"2009","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.ejpb.2011.04.017_b0040","doi-asserted-by":"crossref","first-page":"7971","DOI":"10.1158\/0008-5472.CAN-04-1231","article-title":"Aerosol delivery of glucosylated polyethylenimine\/phosphatase and tensin homologue deleted on chromosome 10 complex suppresses Akt downstream pathways in the lung of K-ras null mice","volume":"64","author":"Kim","year":"2004","journal-title":"Can. Res."},{"key":"10.1016\/j.ejpb.2011.04.017_b0045","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.pupt.2007.04.002","article-title":"Biodistribution in mice and severity of damage in rat lungs following pulmonary delivery of 9-nitrocamptothecin liposomes","volume":"21","author":"Zhang","year":"2008","journal-title":"Pulm. Pharm. Ther."},{"key":"10.1016\/j.ejpb.2011.04.017_b0050","first-page":"3258","article-title":"Paclitaxel liposome aerosol treatment induces inhibition of pulmonary metastases in murine renal carcinoma model","volume":"7","author":"Koshkina","year":"2001","journal-title":"Clin. Can. Res."},{"key":"10.1016\/j.ejpb.2011.04.017_b0055","first-page":"308","article-title":"Microparticles and liposomes as pulmonary drug delivery systems: what are the recent trends?","author":"Ugwoke","year":"2007"},{"key":"10.1016\/j.ejpb.2011.04.017_b0060","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1164\/ajrccm\/140.3.624","article-title":"Four-times-a-day dosing frequency is better than a twice-a-day regimen in subjects requiring a high-dose inhaled steroid, budesonides to control moderate to severe asthma","volume":"140","author":"Malo","year":"1989","journal-title":"Am. Rev. Respir. Dis."},{"key":"10.1016\/j.ejpb.2011.04.017_b0065","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.jconrel.2005.09.034","article-title":"Block copolymer micelles for drug delivery: design, characterization and biological significance","volume":"109","author":"Kataoka","year":"2005","journal-title":"J. Controlled Release"},{"key":"10.1016\/j.ejpb.2011.04.017_b0070","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.jconrel.2005.01.003","article-title":"Novel sustained release microspheres for pulmonary drug delivery","volume":"104","author":"Cook","year":"2005","journal-title":"J. Controlled Release"},{"key":"10.1016\/j.ejpb.2011.04.017_b0075","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.ejps.2007.02.008","article-title":"Chitosan nanoparticles are compatible with respiratory epithelial cells in vitro","volume":"31","author":"Grenha","year":"2007","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2011.04.017_b0080","first-page":"1","article-title":"Nanocarriers as pulmonary drug delivery systems to treat and to diagnose respiratory and non respiratory diseases","volume":"3","author":"Smola","year":"2008","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.ejpb.2011.04.017_b0085","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.ijpharm.2010.05.032","article-title":"Biodegradable nano-micro carrier systems for sustained pulmonary drug delivery: (I) self-assembled nanoparticles encapsulated in respirable\/swellable semi-IPN microspheres","volume":"395","author":"El-Sherbiny","year":"2010","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2011.04.017_b0090","doi-asserted-by":"crossref","first-page":"3095","DOI":"10.1166\/jnn.2006.426","article-title":"Characterization of PEG\u2013lipid micelles for pulmonary delivery of beclomethasone dipropionate","volume":"6","author":"Gaber","year":"2006","journal-title":"J. Nanosci. Nanotech."},{"key":"10.1016\/j.ejpb.2011.04.017_b0095","doi-asserted-by":"crossref","first-page":"319","DOI":"10.2174\/156720105774370221","article-title":"Lipid-core micelles for targeted drug delivery current drug delivery","volume":"2","author":"Torchilin","year":"2005","journal-title":"Curr. Drug Deliv."},{"key":"10.1016\/j.ejpb.2011.04.017_b0100","doi-asserted-by":"crossref","first-page":"4669","DOI":"10.2174\/138161206779026245","article-title":"PEG\u2013lipid micelles for drug delivery","volume":"12","author":"Croy","year":"2006","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.ejpb.2011.04.017_b0105","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.ijpharm.2006.02.018","article-title":"Polyethylene glycol phosphatidylethanolamine conjugate (PEG\u2013PE)-based mixed micelles: some properties, loading with paclitaxel, and modulation of P-glycoprotein-mediated efflux","volume":"315","author":"Dabholkar","year":"2006","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2011.04.017_b0110","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0168-3659(03)00217-7","article-title":"Micelles from polyethylene glycol\/phosphatidylethanolamine conjugates for tumor drug delivery","volume":"91","author":"Lukyanov","year":"2003","journal-title":"J. Controlled Release"},{"key":"10.1016\/j.ejpb.2011.04.017_b0115","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1093\/jnci\/85.5.384","article-title":"Phase II study of taxol in patients with untreated advanced non-small cell lung cancer","volume":"85","author":"Murphy","year":"1993","journal-title":"J. Nat. Cancer Inst. (Bethesda)"},{"key":"10.1016\/j.ejpb.2011.04.017_b0120","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1056\/NEJM199504133321507","article-title":"Paclitaxel (Taxol)","volume":"332","author":"Rowinsky","year":"1995","journal-title":"New Engl. J. Med."},{"key":"10.1016\/j.ejpb.2011.04.017_b0125","doi-asserted-by":"crossref","first-page":"144S","DOI":"10.1378\/chest.117.4_suppl_1.144S","article-title":"Paclitaxel and docetaxel combinations in non-small cell lung cancer","volume":"114","author":"Belani","year":"2000","journal-title":"Chest"},{"key":"10.1016\/j.ejpb.2011.04.017_b0130","unstructured":"V.P. Torchilin, Microencapsulation of poorly soluble anticancer drugs into micelles made of polyethylene glycol\u2013phosphatidylethanolamine (PEG\u2013PE) conjugates, in: 15th International Symposium on Microencapsulation, Parma, Italy, 2005, pp. 18\u201321."},{"key":"10.1016\/j.ejpb.2011.04.017_b0135","first-page":"447","article-title":"Simulants of lung interstitial fluid","volume":"36","author":"Moss","year":"1979","journal-title":"Health Phys."},{"key":"10.1016\/j.ejpb.2011.04.017_b0140","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.jconrel.2009.04.024","article-title":"Multi-drug loaded PEG\u2013lipid micelles for simultaneous delivery of poorly soluble anticancer drugs","volume":"140","author":"Shin","year":"2009","journal-title":"J. Controlled Release"},{"key":"10.1016\/j.ejpb.2011.04.017_b0145","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.ijpharm.2005.11.032","article-title":"Hydrophilic matrices, application of Placket\u2013Burman screening design to model the effect of POLYOX\u2013carbopol blends on drug release","volume":"309","author":"El-Malah","year":"2006","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2011.04.017_b0150","doi-asserted-by":"crossref","first-page":"7382","DOI":"10.1158\/1078-0432.CCR-04-0334","article-title":"Antitumor activity of hydrophilic paclitaxel copolymer prodrug using locoregional delivery in human orthotopic non-small cell lung cancer xenograft models","volume":"10","author":"Zou","year":"2004","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.ejpb.2011.04.017_b0155","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1023\/A:1026118813943","article-title":"Pulmonary absorption of insulin mediated by tetradecyl-maltoside and dimethyl-cyclodextrin","volume":"20","author":"Hussain","year":"2003","journal-title":"Pharm. Res."},{"key":"10.1016\/j.ejpb.2011.04.017_b0160","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.1002\/jps.20849","article-title":"Dendrimers as a carrier for pulmonary delivery of enoxaparin, a low-molecular weight heparin","volume":"96","author":"Bai","year":"2007","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2011.04.017_b0165","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.jpba.2005.02.023","article-title":"Sensitive HPLC method for quantitation of paclitaxel (Genexol\u00ae) in biological samples with application to preclinical pharmacokinetics and biodistribution","volume":"39","author":"Kim","year":"2005","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.ejpb.2011.04.017_b0170","doi-asserted-by":"crossref","first-page":"2476","DOI":"10.1002\/jps.20150","article-title":"In vitro characterization of PEGylated phospholipid micelles for improved drug solubilization: effects of PEG chain length and PC incorporation","volume":"93","author":"Ashok","year":"2004","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2011.04.017_b0175","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0378-5173(00)00634-7","article-title":"Drug delivery by phospholipase A2 degradable liposomes","volume":"214","author":"Davidsen","year":"2001","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2011.04.017_b0180","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1016\/j.addr.2003.12.004","article-title":"Micelles from lipid derivatives of water-soluble polymers as delivery systems for poorly soluble drugs","volume":"56","author":"Lukyanov","year":"2004","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.ejpb.2011.04.017_b0185","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.jconrel.2005.09.034","article-title":"Block copolymer micelles: preparation, characterization and application in drug delivery","volume":"109","author":"Gaucher","year":"2005","journal-title":"J. Controlled Release"},{"key":"10.1016\/j.ejpb.2011.04.017_b0190","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.ijpharm.2008.02.011","article-title":"Inhaled nanoparticles\u2014a current review","volume":"356","author":"Yang","year":"2008","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2011.04.017_b0195","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/0378-5173(96)04449-3","article-title":"Nebulisation of monodisperse latex sphere suspensions in air-jet and ultrasonic nebulisers","volume":"133","author":"McCallion","year":"1996","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2011.04.017_b0200","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1080\/02786820490465513","article-title":"Analysis of total respiratory deposition of inhaled ultrafine particles in adult subjects as various breathing patterns","volume":"38","author":"Kim","year":"2004","journal-title":"Aerosol Sci. Technol."},{"key":"10.1016\/j.ejpb.2011.04.017_b0205","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s004200000185","article-title":"Pulmonary effects of inhaled ultrafine particles","volume":"74","author":"Oberdorster","year":"2001","journal-title":"Int. Arch. Occup. Environ. Health"},{"key":"10.1016\/j.ejpb.2011.04.017_b0210","doi-asserted-by":"crossref","first-page":"748","DOI":"10.3181\/00379727-107-26743","article-title":"Effect of size and concentration of latex particles on respiration of human blood leucocytes","volume":"107","author":"Krenis","year":"1961","journal-title":"Proc. Soc. Exp. Biol. (NY)"},{"key":"10.1016\/j.ejpb.2011.04.017_b0215","first-page":"4460","article-title":"Design of liposomes to improve delivery of macrophage-augmenting agents to alveolar macrophages","volume":"40","author":"Fidler","year":"1980","journal-title":"Cancer Res."},{"key":"10.1016\/j.ejpb.2011.04.017_b0220","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0168-3659(01)00440-0","article-title":"Fabrication, characterization and in vitro release of paclitaxel (Taxol) loaded poly (lactic-co-glycolic acid) microspheres prepared by spray drying technique with lipid\/cholesterol emulsifiers","volume":"76","author":"Mu","year":"2001","journal-title":"J. Controlled Release"},{"key":"10.1016\/j.ejpb.2011.04.017_b0225","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.colsurfb.2010.07.050","article-title":"Preparation and characterization of biodegradable paclitaxel loaded alginate microparticles for pulmonary delivery","volume":"81","author":"Alipour","year":"2010","journal-title":"Coll. Surf. B: Biol."},{"key":"10.1016\/j.ejpb.2011.04.017_b0230","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1021\/js9605226","article-title":"Solid-state characterization of paclitaxel","volume":"86","author":"Liggins","year":"1997","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2011.04.017_b0235","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0168-3659(01)00248-6","article-title":"On the importance and mechanisms of burst release in matrix-controlled drug delivery systems","volume":"73","author":"Huang","year":"2001","journal-title":"J. Controlled Release"},{"key":"10.1016\/j.ejpb.2011.04.017_b0240","first-page":"317","article-title":"Polymeric micelles for formulation of anticancer drugs","author":"Lee","year":"2006"},{"key":"10.1016\/j.ejpb.2011.04.017_b0245","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1016\/j.biomaterials.2007.11.029","article-title":"Pharmacokinetics, biodistribution, efficacy and safety of N-octyl-O-sulfate chitosan micelles loaded with paclitaxel","volume":"29","author":"Zhang","year":"2008","journal-title":"Biomaterials"},{"key":"10.1016\/j.ejpb.2011.04.017_b0250","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1080\/10611860400013451","article-title":"Biodistribution and targeting potential of poly(ethylene glycol) modified gelatin nanoparticles in subcutaneous murine tumor model","volume":"2","author":"Kaul","year":"2004","journal-title":"J. Drug Target."},{"key":"10.1016\/j.ejpb.2011.04.017_b0255","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1093\/toxsci\/kfm018","article-title":"Assessing toxicity of fine and nanoparticles: comparing in vitro measurements to in vivo pulmonary toxicity profiles","volume":"7","author":"Sayes","year":"2007","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.ejpb.2011.04.017_b0260","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.ejpb.2010.02.014","article-title":"A toxicological evaluation of inhaled solid lipid nanoparticles used as a potential drug delivery system for the lung","volume":"75","author":"Nassimi","year":"2010","journal-title":"Eur. J. Pharm. Biopharm."}],"container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641111001597?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641111001597?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,10]],"date-time":"2019-06-10T13:17:18Z","timestamp":1560172638000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0939641111001597"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10]]},"references-count":52,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,10]]}},"alternative-id":["S0939641111001597"],"URL":"https:\/\/doi.org\/10.1016\/j.ejpb.2011.04.017","relation":{},"ISSN":["0939-6411"],"issn-type":[{"value":"0939-6411","type":"print"}],"subject":[],"published":{"date-parts":[[2011,10]]}}}