{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T17:32:50Z","timestamp":1791048770004,"version":"4.1.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"published-print":{"date-parts":[[2011,10]]},"DOI":"10.1016\/j.ejpb.2011.05.001","type":"journal-article","created":{"date-parts":[[2011,5,12]],"date-time":"2011-05-12T14:06:51Z","timestamp":1305209211000},"page":"372-381","source":"Crossref","is-referenced-by-count":43,"title":["Tailor-made release triggering from hot-melt extruded complexes of basic polyelectrolyte and poorly water-soluble drugs"],"prefix":"10.1016","volume":"79","author":[{"given":"Christoph","family":"Kindermann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Matth\u00e9e","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jutta","family":"Strohmeyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Sievert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"Breitkreutz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejpb.2011.05.001_b0005","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0939-6411(02)00061-9","article-title":"Melt extrusion: from process to drug delivery technology","volume":"54","author":"Breitenbach","year":"2002","journal-title":"European Journal of Pharmaceutics and Biopharmaceutics"},{"key":"10.1016\/j.ejpb.2011.05.001_b0010","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1351\/pac200678112067","article-title":"Terminology of polymers containing ionizable or ionic groups and of polymers containing ions (IUPAC recommendations 2006)","volume":"78","author":"Hess","year":"2006","journal-title":"Pure and Applied Chemistry"},{"key":"10.1016\/j.ejpb.2011.05.001_b0015","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1002\/(SICI)1521-3935(19990101)200:1<118::AID-MACP118>3.0.CO;2-K","article-title":"Polyelectrolyte complex formation in highly aggregating systems. Effect of salt: response to subsequent addition of NaCl","volume":"200","author":"Dautzenberg","year":"1999","journal-title":"Macromolecular Chemistry and Physics"},{"key":"10.1016\/j.ejpb.2011.05.001_b0020","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1021\/ie50670a007","article-title":"Polyelectrolyte complexes","volume":"57","author":"Michaels","year":"1965","journal-title":"Industrial & Engineering Chemistry"},{"key":"10.1016\/j.ejpb.2011.05.001_b0025","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1080\/10837450802202098","article-title":"Controlled release solid dosage forms using combinations of (meth)acrylate copolymers","volume":"13","author":"Gallardo","year":"2008","journal-title":"Pharmaceutical Development and Technology"},{"key":"10.1016\/j.ejpb.2011.05.001_b0030","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.ejpb.2008.04.008","article-title":"Comparative evaluation of interpolyelectrolyte complexes of chitosan with Eudragit\u00ae L100 and Eudragit\u00ae L100-55 as potential carriers for oral controlled drug delivery","volume":"70","author":"Moustafine","year":"2008","journal-title":"European Journal of Pharmaceutics and Biopharmaceutics"},{"key":"10.1016\/j.ejpb.2011.05.001_b0035","doi-asserted-by":"crossref","first-page":"481","DOI":"10.4103\/0250-474X.58165","article-title":"Polyelectrolyte complexes: a review of their applicability in drug delivery technology","volume":"71","author":"Lankalapalli","year":"2009","journal-title":"Indian Journal of Pharmaceutical Sciences"},{"key":"10.1016\/j.ejpb.2011.05.001_b0040","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.ijpharm.2003.09.008","article-title":"The improvement of aqueous chemical stability of a model basic drug by ion pairing with acid groups of polyelectrolytes","volume":"269","author":"Jimenez-Kairuz","year":"2004","journal-title":"International Journal of Pharmaceutics"},{"key":"10.1016\/j.ejpb.2011.05.001_b0045","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.ejpb.2010.06.012","article-title":"Enhancement of sustained and controlled protein release using polyelectrolyte complex-loaded injectable and thermosensitive hydrogel","volume":"76","author":"Park","year":"2010","journal-title":"European Journal of Pharmaceutics and Biopharmaceutics"},{"key":"10.1016\/j.ejpb.2011.05.001_b0050","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1615\/CritRevTherDrugCarrierSyst.v16.i2.10","article-title":"Gene-delivery systems using cationic polymers","volume":"16","author":"Garnett","year":"1999","journal-title":"Critical Reviews in Therapeutic Drug Carrier Systems"},{"key":"10.1016\/j.ejpb.2011.05.001_b0055","unstructured":"A. Vincze, M. Assmus, K. Lehmann, H.-U. Petereit, Verfahren zur Herstellung eines komplexierten Arzneimittels, EP 0 417 588, 1992."},{"key":"10.1016\/j.ejpb.2011.05.001_b0060","unstructured":"H.-U. Petereit, C. Meier, A. Gryczke, Method for Producing an Immediately Decomposing Oral Form of Administration which Releases Active Ingredients, WO\/2004\/066976, 2004."},{"key":"10.1016\/j.ejpb.2011.05.001_b0065","unstructured":"H.-U. Petereit, C. Meier, A. Gryczke, Melt Extrusion Consisting of Salts of Active Ingredients, WO\/2003\/072083, 2003."},{"key":"10.1016\/j.ejpb.2011.05.001_b0070","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1002\/jps.20932","article-title":"Microenvironmental pH modulation in solid dosage forms","volume":"96","author":"Badawy","year":"2007","journal-title":"Journal of Pharmaceutical Sciences"},{"key":"10.1016\/j.ejpb.2011.05.001_b0075","unstructured":"H.-U. Petereit, T. Beckert, E. Lynenskjold, Coated Medicament Forms with Controlled Active Substance Release, WO\/2000\/019984, 2000."},{"key":"10.1016\/j.ejpb.2011.05.001_b0080","unstructured":"N. Pearnchob, T. Friedl, K.G. Wagner, F. Sommer, Controlled Release System and Method for Manufacturing the Same, US 2008\/0069873, 2008."},{"key":"10.1016\/j.ejpb.2011.05.001_b0085","unstructured":"R. Brickl, U. Brauns, T. Friedl, Orally Administrable Dosage Form for Poorly Soluble Acids and Amphotheric Active Ingredients, WO 2005\/023223, 2005."},{"key":"10.1016\/j.ejpb.2011.05.001_b0090","unstructured":"U. Brauns, R. Brickl, Oral Administration Form for Difficulty Soluble Basic Active Ingredients which are Applied Orally, WO 03\/074032, 2003."},{"key":"10.1016\/j.ejpb.2011.05.001_b0095","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1063\/1.1629271","article-title":"Precipitation of oppositely charged polyelectrolytes in salt solutions","volume":"120","author":"Kudlay","year":"2004","journal-title":"The Journal of Chemical Physics"},{"key":"10.1016\/j.ejpb.2011.05.001_b0100","doi-asserted-by":"crossref","first-page":"7810","DOI":"10.1021\/ma970803f","article-title":"Polyelectrolyte complex formation in highly aggregating systems. 1. Effect of salt: polyelectrolyte complex formation in the presence of NaCl","volume":"30","author":"Dautzenberg","year":"1997","journal-title":"Macromolecules"},{"key":"10.1016\/j.ejpb.2011.05.001_b0105","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1002\/jps.10036","article-title":"Mechanism of lidocaine release from carbomer\u2013lidocaine hydrogels","volume":"91","author":"Jimenez-Kairuz","year":"2002","journal-title":"Journal of Pharmaceutical Sciences"},{"key":"10.1016\/j.ejpb.2011.05.001_b0110","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0378-5173(02)00525-2","article-title":"Equilibrium properties and mechanism of kinetic release of metoclopramide from carbomer hydrogels","volume":"250","author":"Jimenez-Kairuz","year":"2003","journal-title":"International Journal of Pharmaceutics"},{"key":"10.1016\/j.ejpb.2011.05.001_b0115","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.ejps.2007.10.002","article-title":"Interaction between a cationic polymethacrylate (Eudragit E100) and anionic drugs","volume":"33","author":"Quinteros","year":"2008","journal-title":"European Journal of Pharmaceutical Sciences"},{"key":"10.1016\/j.ejpb.2011.05.001_b0120","unstructured":"European Pharmacopeia, sixth ed. (6.8), Strasbourg Cedex, France, 2010."},{"key":"10.1016\/j.ejpb.2011.05.001_b0125","doi-asserted-by":"crossref","first-page":"767","DOI":"10.3109\/03639048309039887","article-title":"Dissociation-constants, solubilities and dissolution rates of some selected non-steroidal antiinflammatories","volume":"9","author":"Herzfeldt","year":"1983","journal-title":"Drug Development and Industrial Pharmacy"},{"key":"10.1016\/j.ejpb.2011.05.001_b0130","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1081\/DDC-100102305","article-title":"Basic coating polymers for the colon-specific drug delivery in inflammatory bowel disease","volume":"26","author":"Leopold","year":"2000","journal-title":"Drug Development and Industrial Pharmacy"},{"key":"10.1016\/j.ejpb.2011.05.001_b0135","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1021\/cr60298a003","article-title":"Solubility parameters","volume":"75","author":"Barton","year":"1975","journal-title":"Chemical Reviews"},{"key":"10.1016\/j.ejpb.2011.05.001_b0140","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1023\/A:1011941319327","article-title":"Prediction of intestinal drug absorption properties by three-dimensional solubility parameters","volume":"15","author":"Breitkreutz","year":"1998","journal-title":"Pharmaceutical Research"},{"key":"10.1016\/j.ejpb.2011.05.001_b0145","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1021\/i360029a002","article-title":"The universality of the solubility parameter","volume":"8","author":"Hansen","year":"1969","journal-title":"Product R&D"},{"key":"10.1016\/j.ejpb.2011.05.001_b0150","unstructured":"D.W. Van Krevelen, P.J. Hoftyzer, Properties of Polymers. Their Estimation and Correlation with Chemical Structures, Amsterdam, 1976."},{"key":"10.1016\/j.ejpb.2011.05.001_b0155","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1002\/jps.22313","article-title":"Evaluation of predictive models for stable solid solution formation","volume":"100","author":"Albers","year":"2011","journal-title":"Journal of Pharmaceutical Sciences"},{"key":"10.1016\/j.ejpb.2011.05.001_b0160","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.ijpharm.2007.11.048","article-title":"Characterisation of solid dispersions of paracetamol and EUDRAGIT\u00ae E prepared by hot-melt extrusion using thermal, microthermal and spectroscopic analysis","volume":"354","author":"Qi","year":"2008","journal-title":"International Journal of Pharmaceutics"},{"key":"10.1016\/j.ejpb.2011.05.001_b0165","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1002\/jps.2600600902","article-title":"Pharmaceutical applications of solid dispersion systems","volume":"60","author":"Chiou","year":"1971","journal-title":"Journal of Pharmaceutical Sciences"},{"key":"10.1016\/j.ejpb.2011.05.001_b0170","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1007\/s11095-010-0185-8","article-title":"Characterisation and prediction of phase separation in hot-melt extruded solid dispersions: a thermal, microscopic and NMR relaxometry study","volume":"27","author":"Qi","year":"2010","journal-title":"Pharmaceutical Research"},{"key":"10.1016\/j.ejpb.2011.05.001_b0175","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.ejpb.2005.10.005","article-title":"Physicochemical characterization and drug release properties of Eudragit (R) E PO\/Eudragit (R) L 100-55 interpolyelectrolyte complexes","volume":"63","author":"Moustafine","year":"2006","journal-title":"European Journal of Pharmaceutics and Biopharmaceutics"},{"key":"10.1016\/j.ejpb.2011.05.001_b0180","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.ejpb.2008.10.002","article-title":"Mechanism of drug release from polymethacrylate-based extrudates and milled strands prepared by hot-melt extrusion","volume":"71","author":"Albers","year":"2009","journal-title":"European Journal of Pharmaceutics and Biopharmaceutics"},{"key":"10.1016\/j.ejpb.2011.05.001_b0185","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1023\/A:1018956304595","article-title":"Confocal Raman-spectroscopy: analytical approach to solid dispersions and mapping of drugs","volume":"16","author":"Breitenbach","year":"1999","journal-title":"Pharmaceutical Research"},{"key":"10.1016\/j.ejpb.2011.05.001_b0190","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.ijpharm.2008.01.036","article-title":"Off-line and on-line measurements of drug-loaded hot-melt extruded films using Raman spectroscopy","volume":"357","author":"Tumuluri","year":"2008","journal-title":"International Journal of Pharmaceutics"},{"key":"10.1016\/j.ejpb.2011.05.001_b0195","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.ejpb.2010.09.015","article-title":"Raman spectroscopy for the in-line polymer\u2013drug quantification and solid state characterization during a pharmaceutical hot-melt extrusion process","volume":"77","author":"Saerens","year":"2011","journal-title":"European Journal of Pharmaceutics and Biopharmaceutics"},{"key":"10.1016\/j.ejpb.2011.05.001_b0200","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1021\/js9601896","article-title":"Characteristics and significance of the amorphous state in pharmaceutical systems","volume":"86","author":"Hancock","year":"1997","journal-title":"Journal of Pharmaceutical Sciences"},{"key":"10.1016\/j.ejpb.2011.05.001_b0205","doi-asserted-by":"crossref","first-page":"2941","DOI":"10.1002\/jps.22074","article-title":"Drug\u2013polymer solubility and miscibility: stability consideration and practical challenges in amorphous solid dispersion development","volume":"99","author":"Qian","year":"2010","journal-title":"Journal of Pharmaceutical Sciences"}],"container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641111001615?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641111001615?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,11,22]],"date-time":"2021-11-22T23:48:06Z","timestamp":1637624886000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0939641111001615"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,10]]}},"alternative-id":["S0939641111001615"],"URL":"https:\/\/doi.org\/10.1016\/j.ejpb.2011.05.001","relation":{},"ISSN":["0939-6411"],"issn-type":[{"value":"0939-6411","type":"print"}],"subject":[],"published":{"date-parts":[[2011,10]]}}}