{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T13:34:48Z","timestamp":1791207288690,"version":"4.1.0"},"reference-count":52,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"published-print":{"date-parts":[[2012,2]]},"DOI":"10.1016\/j.ejpb.2011.10.015","type":"journal-article","created":{"date-parts":[[2011,11,1]],"date-time":"2011-11-01T15:36:53Z","timestamp":1320161813000},"page":"306-314","source":"Crossref","is-referenced-by-count":109,"title":["Nanoparticulate lipid dispersions for bromocriptine delivery: Characterization and in vivo study"],"prefix":"10.1016","volume":"80","author":[{"given":"Elisabetta","family":"Esposito","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Mariani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Ravani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catia","family":"Contado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattia","family":"Volta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Bido","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Drechsler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serena","family":"Mazzoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enea","family":"Menegatti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Morari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Cortesi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejpb.2011.10.015_b0005","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.cis.2008.07.007","article-title":"Characterization and potential applications of nanostructured aqueous dispersions","volume":"148","author":"Yaghmur","year":"2009","journal-title":"Adv. Coll. Interf. Sci."},{"key":"10.1016\/j.ejpb.2011.10.015_b0010","series-title":"Microencapsulation","first-page":"213","article-title":"Biodegradable colloidal drug carrier systems based on solid lipids","author":"Westesen","year":"1996"},{"key":"10.1016\/j.ejpb.2011.10.015_b0015","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0939-6411(00)00087-4","article-title":"Solid lipid nanoparticles (SLN) for controlled delivery \u2013 a review of the state of the art","volume":"50","author":"Muller","year":"2000","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ejpb.2011.10.015_b0020","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.ijpharm.2008.10.003","article-title":"Lipid nanoparticles (SLN,NLC) in cosmetic and pharmaceutical dermal products","volume":"366","author":"Pardeike","year":"2009","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2011.10.015_b0025","doi-asserted-by":"crossref","first-page":"S131s","DOI":"10.1016\/S0169-409X(02)00118-7","article-title":"Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations","volume":"54","author":"Muller","year":"2002","journal-title":"Adv. Drug Del. Rev."},{"key":"10.1016\/j.ejpb.2011.10.015_b0030","doi-asserted-by":"crossref","first-page":"4611","DOI":"10.1021\/la960318y","article-title":"Cubic lipid\/water phase dispersed into submicron particles","volume":"12","author":"Gustafsson","year":"1996","journal-title":"Langmuir"},{"key":"10.1016\/j.ejpb.2011.10.015_b0035","doi-asserted-by":"crossref","first-page":"5254","DOI":"10.1021\/la0499416","article-title":"Reversible phase transitions in emulsified nanostructured lipid systems","volume":"20","author":"de campo","year":"2004","journal-title":"Langmuir"},{"key":"10.1016\/j.ejpb.2011.10.015_b0040","doi-asserted-by":"crossref","first-page":"6964","DOI":"10.1021\/la970566+","article-title":"Submicron particles of reversed lipid phases in water stabilized by a nonionic amphiphilic polymer","volume":"13","author":"Gustafsson","year":"1997","journal-title":"Langmuir"},{"key":"10.1016\/j.ejpb.2011.10.015_b0045","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1208\/ps050430","article-title":"Lipid based supramolecular systems for topical application: a preformulatory study","volume":"5","author":"Esposito","year":"2003","journal-title":"AAPS Pharm. Sci."},{"key":"10.1016\/j.ejpb.2011.10.015_b0050","doi-asserted-by":"crossref","first-page":"5748","DOI":"10.1021\/la010161w","article-title":"Novel process for producing cubic liquid crystalline nanoparticles (cubosomes)","volume":"17","author":"Spicer","year":"2001","journal-title":"Langmuir"},{"key":"10.1016\/j.ejpb.2011.10.015_b0055","doi-asserted-by":"crossref","first-page":"3917","DOI":"10.1021\/la010224a","article-title":"Small angle X-ray scattering and 13C NMR investigation on the internal structure of cubosome","volume":"17","author":"Nakano","year":"2001","journal-title":"Langmuir"},{"key":"10.1016\/j.ejpb.2011.10.015_b0060","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.cocis.2006.07.002","article-title":"Investigating reversed liquid crystalline mesophases","volume":"11","author":"Sagalowicz","year":"2006","journal-title":"Curr. Opin. Colloid Interf. Sci."},{"key":"10.1016\/j.ejpb.2011.10.015_b0065","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1208\/s12249-009-9292-4","article-title":"Glyceryl monooleate\/Poloxamer 407 cubic nanoparticles as oral drug delivery systems: I. In vitro evaluation and enhanced oral bioavailability of the poorly water-soluble drug simvastatin","volume":"10","author":"Lai","year":"2009","journal-title":"AAPS Pharm. Sci. Technol."},{"key":"10.1016\/j.ejpb.2011.10.015_b0070","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1517\/17425240902939143","article-title":"The potential for nanoparticle-based drug delivery to the brain: overcoming the blood\u2013brain barrier","volume":"6","author":"Barbu","year":"2009","journal-title":"Expert Opin. Drug Del."},{"key":"10.1016\/j.ejpb.2011.10.015_b0075","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1517\/17425240903405581","article-title":"Various drug delivery approaches to the central nervous system","volume":"7","author":"Pasha","year":"2010","journal-title":"Expert Opin. Drug Del."},{"key":"10.1016\/j.ejpb.2011.10.015_b0080","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.2174\/1381612043384826","article-title":"New technologies for drug delivery across the blood brain barrier","volume":"10","author":"Kabanov","year":"2004","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.ejpb.2011.10.015_b0085","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1002\/wnan.5","article-title":"Polyalkylcyanoacrylate nanoparticles for delivery of drugs across the blood\u2013brain barrier","volume":"1","author":"Andrieux","year":"2009","journal-title":"Nanomed. Nanobiotechnol."},{"key":"10.1016\/j.ejpb.2011.10.015_b0090","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.jconrel.2007.12.018","article-title":"Potential of solid lipid nanoparticles in brain targeting","volume":"127","author":"Kaur","year":"2008","journal-title":"J. Control. Rel."},{"key":"10.1016\/j.ejpb.2011.10.015_b0095","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.ejpb.2008.09.003","article-title":"Lipid nanoparticles for parenteral delivery of actives","volume":"71","author":"Joshi","year":"2009","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ejpb.2011.10.015_b0100","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1007\/s11095-007-9514-y","article-title":"Solid lipid nanoparticles as delivery systems for bromocriptine","volume":"25","author":"Esposito","year":"2008","journal-title":"Pharm. Res."},{"key":"10.1016\/j.ejpb.2011.10.015_b0105","unstructured":"http:\/\/www.fscimage.fishersci.com\/msds\/06352.html."},{"key":"10.1016\/j.ejpb.2011.10.015_b0110","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1007\/s11095-005-8176-x","article-title":"Cubosome dispersions as delivery systems for percutaneous administration of indomethacin","volume":"22","author":"Esposito","year":"2005","journal-title":"Pharm. Res."},{"key":"10.1016\/j.ejpb.2011.10.015_b0115","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1023\/A:1010067107182","article-title":"Dynamic light scattering measurement of nanometer particles in liquids","volume":"2","author":"Pecora","year":"2000","journal-title":"J. Nanoparticle Res."},{"key":"10.1016\/j.ejpb.2011.10.015_b0120","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.chroma.2007.04.038","article-title":"Complementary use of flow and sedimentation field-flow fractionation techniques for size characterizing biodegradable poly(lactic acid) nanospheres","volume":"1157","author":"Contado","year":"2007","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.ejpb.2011.10.015_b0125","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0927-7757(96)03717-X","article-title":"Characterisation of River Po particles by sedimentation field-flow fractionation coupled to GFAAS and ICP-MS","volume":"120","author":"Contado","year":"1997","journal-title":"Colloid Surf. A \u2013 Physicochem. Eng. Asp."},{"key":"10.1016\/j.ejpb.2011.10.015_b0130","doi-asserted-by":"crossref","first-page":"8056","DOI":"10.1021\/jp100437v","article-title":"Multi- to unilamellar transitions in catanionic vesicles","volume":"114","author":"Andreozzi","year":"2010","journal-title":"J. Phys. Chem. B"},{"key":"10.1016\/j.ejpb.2011.10.015_b0135","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/0022-2836(88)90607-9","article-title":"Cubic phases of lipid containing systems. Structure analysis and biological implications","volume":"204","author":"Mariani","year":"1988","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.ejpb.2011.10.015_b0140","doi-asserted-by":"crossref","first-page":"6484","DOI":"10.1021\/la9039623","article-title":"Melting regime of the anionic phospholipid DMPG: new lamellar phase and porous bilayer model","volume":"26","author":"Spinozzi","year":"2010","journal-title":"Langmuir"},{"key":"10.1016\/j.ejpb.2011.10.015_b0145","doi-asserted-by":"crossref","first-page":"9591","DOI":"10.1523\/JNEUROSCI.2546-05.2005","article-title":"Blockade of nociceptin\/orphanin FQ transmission attenuates symptoms and neurodegeneration associated with Parkinson\u2019s disease","volume":"95","author":"Marti","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejpb.2011.10.015_b0150","series-title":"The rat brain in stereotaxic coordinates","author":"Paxinos","year":"1982"},{"key":"10.1016\/j.ejpb.2011.10.015_b0155","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1523\/JNEUROSCI.4346-06.2007","article-title":"The nociceptin\/orphanin FQ receptor antagonist J-113397 and L-DOPA additively attenuate experimental parkinsonism through overinhibition of the nigrothalamic pathway","volume":"27","author":"Marti","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejpb.2011.10.015_b0160","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1046\/j.1471-4159.2002.01169.x","article-title":"Striatal dopamine-NMDA receptor interactions in the modulation of glutamate release in the substantia nigra pars reticulata in vivo. Opposite role for D1 and D2 receptors","volume":"83","author":"Marti","year":"2002","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ejpb.2011.10.015_b0165","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1037\/0735-7044.102.5.748","article-title":"The catalepsy test: its ups and downs","volume":"102","author":"Sanberg","year":"1988","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.ejpb.2011.10.015_b0170","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0014-4886(79)90003-7","article-title":"Excessive bracing reactions and their control by atropine and L-DOPA in an animal analog of Parkinsonism","volume":"64","author":"Schallert","year":"1979","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.ejpb.2011.10.015_b0175","doi-asserted-by":"crossref","first-page":"565","DOI":"10.3109\/02652049409034995","article-title":"Kinetic of bromocriptine release from microspheres: comparative analysis between different in vitro models","volume":"11","author":"Nastruzzi","year":"1993","journal-title":"J. Microencapsul."},{"key":"10.1016\/j.ejpb.2011.10.015_b0180","first-page":"239","article-title":"Preformed gelatin microspheres as a delivery system for bromocriptine","volume":"4","author":"Esposito","year":"1994","journal-title":"Pharm. Sci. Comm."},{"key":"10.1016\/j.ejpb.2011.10.015_b0185","doi-asserted-by":"crossref","first-page":"197","DOI":"10.4103\/0253-7613.56070","article-title":"Bromocriptine mesylate: FDA-approved novel treatment for type-2 diabetes","volume":"41","author":"Mahajan","year":"2009","journal-title":"Indian J. Pharmacol."},{"key":"10.1016\/j.ejpb.2011.10.015_b0190","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1248\/bpb.30.350","article-title":"Cubosomes: an overview","volume":"30","author":"Garg","year":"2007","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.ejpb.2011.10.015_b0195","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0169-409X(01)00108-9","article-title":"Cubic phase gels as drug delivery systems","volume":"47","author":"Shah","year":"2001","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.ejpb.2011.10.015_b0200","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.jconrel.2003.11.012","article-title":"Investigations on the structure of solid lipid nanoparticles (SLN) and oil-loaded solid lipid nanoparticles by photon correlation spectroscopy, field-flow fractionation and transmission electron microscopy","volume":"95","author":"Jores","year":"2004","journal-title":"J. Control. Rel."},{"key":"10.1016\/j.ejpb.2011.10.015_b0205","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.ijpharm.2006.08.023","article-title":"Influence of composition and preparation parameters on the properties of aqueous Monoolein dispersions","volume":"329","author":"Worle","year":"2007","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2011.10.015_b0210","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0070-2161(08)60205-1","article-title":"The cubic phases of lipids","volume":"44","author":"Luzzati","year":"1997","journal-title":"Curr. Top. Membr."},{"key":"10.1016\/j.ejpb.2011.10.015_b0215","doi-asserted-by":"crossref","first-page":"3109","DOI":"10.1021\/jp001513v","article-title":"Pressure induced cubic-to-cubic phase transition in Monoolein hydrated system","volume":"105","author":"Pisani","year":"2001","journal-title":"J. Phys. Chem. B"},{"key":"10.1016\/j.ejpb.2011.10.015_b0220","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1021\/la052109w","article-title":"Oil-loaded monolinolein-based particles with confined inverse discontinuous cubic structure (Fd3m)","volume":"22","author":"Yaghmur","year":"2006","journal-title":"Langmuir"},{"key":"10.1016\/j.ejpb.2011.10.015_b0225","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1517\/17425240902870405","article-title":"New drug delivery strategies for improved Parkinson\u2019s disease therapy","volume":"6","author":"Di Stefano","year":"2009","journal-title":"Expert Opin. Drug Del."},{"key":"10.1016\/j.ejpb.2011.10.015_b0230","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.pneurobio.2009.05.002","article-title":"Nanotechnological applications for the treatment of neurodegenerative disorders","volume":"88","author":"Modi","year":"2009","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.ejpb.2011.10.015_b0235","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1111\/j.1460-9568.1994.tb00584.x","article-title":"The role of pulsatile versus continuous dopamine receptor stimulation for functional recovery in Parkinson\u2019s disease","volume":"6","author":"Obeso","year":"1994","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.ejpb.2011.10.015_b0240","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0378-4274(01)00447-7","article-title":"Effects of intraperitoneal administration of liposomes and methods of preparing liposomes for local therapy","volume":"126","author":"Sadzuka","year":"2002","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.ejpb.2011.10.015_b0245","doi-asserted-by":"crossref","first-page":"47","DOI":"10.2174\/1573413052953110","article-title":"Nanosystems in drug targeting: opportunities and challenges","volume":"1","author":"Vasir","year":"2005","journal-title":"Curr. Nanosci."},{"key":"10.1016\/j.ejpb.2011.10.015_b0250","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0005-2736(93)90115-G","article-title":"Subcutaneous administration of liposomes: a comparison with the intravenous and intraperitoneal routes of injection","volume":"1150","author":"Allen","year":"1993","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ejpb.2011.10.015_b0255","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.jconrel.2005.02.028","article-title":"Influence of administration route on tumour uptake and biodistribution of etoposide loaded solid lipid nanoparticles in Dalton\u2019s lymphoma tumour bearing mice","volume":"105","author":"Reddy","year":"2005","journal-title":"J. Control. Rel."},{"issue":"2","key":"10.1016\/j.ejpb.2011.10.015_b0260","doi-asserted-by":"crossref","first-page":"161","DOI":"10.5507\/bp.2004.029","article-title":"Pharmacokinetics and biodistribution studies of doxorubicin loaded poly(butyl cyanoacrilate) nanoparticles synthesized by two different techniques","volume":"148","author":"Reddy","year":"2004","journal-title":"Biomed. Papers"}],"container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641111003109?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641111003109?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,11,29]],"date-time":"2018-11-29T01:56:50Z","timestamp":1543456610000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0939641111003109"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2]]},"references-count":52,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,2]]}},"alternative-id":["S0939641111003109"],"URL":"https:\/\/doi.org\/10.1016\/j.ejpb.2011.10.015","relation":{},"ISSN":["0939-6411"],"issn-type":[{"value":"0939-6411","type":"print"}],"subject":[],"published":{"date-parts":[[2012,2]]}}}