{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T07:17:24Z","timestamp":1769843844838,"version":"3.49.0"},"reference-count":52,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"published-print":{"date-parts":[[2013,1]]},"DOI":"10.1016\/j.ejpb.2012.09.007","type":"journal-article","created":{"date-parts":[[2012,9,29]],"date-time":"2012-09-29T16:18:35Z","timestamp":1348935515000},"page":"33-43","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"title":["New cationic nanovesicular systems containing lysine-based surfactants for topical administration: Toxicity assessment using representative skin cell lines"],"prefix":"10.1016","volume":"83","author":[{"given":"Daniele Rubert","family":"Nogueira","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Carmen Mor\u00e1n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Montserrat","family":"Mitjans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ver\u00f3nica","family":"Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lourdes","family":"P\u00e9rez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Pilar Vinardell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejpb.2012.09.007_b0005","first-page":"341","article-title":"Gemini surfactant dimethylene-1,2-bis(tetradecyldimethylammonium bromide)-based gene vectors: a biophysical approach to transfection efficiency","volume":"2011","author":"Cardoso","year":"1808","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ejpb.2012.09.007_b0010","doi-asserted-by":"crossref","first-page":"42","DOI":"10.3109\/09687688.2010.508879","article-title":"Inclusion of a single-tail amino acid-based amphiphile in a lipoplex formulation: effects on transfection efficiency and physicochemical properties","volume":"28","author":"Lundberg","year":"2011","journal-title":"Mol. Membr. Biol."},{"key":"10.1016\/j.ejpb.2012.09.007_b0015","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.ijpharm.2005.02.032","article-title":"In vivo comparison of various liposome formulations for cosmetic application","volume":"296","author":"Betz","year":"2005","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2012.09.007_b0020","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.ejpb.2007.01.020","article-title":"Development and characterization and in vivo evaluation of benzocaine-loaded liposomes","volume":"67","author":"Mura","year":"2007","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ejpb.2012.09.007_b0025","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1016\/j.ejmech.2008.11.003","article-title":"Cationic surfactants from lysine: synthesis, micellization and biological evaluation","volume":"44","author":"P\u00e9rez","year":"2009","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejpb.2012.09.007_b0030","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1021\/jm101315k","article-title":"Cationic surfactants derived from lysine: effects of their structure and charge type on antimicrobial and hemolytic activities","volume":"54","author":"Colomer","year":"2011","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejpb.2012.09.007_b0035","doi-asserted-by":"crossref","first-page":"10606","DOI":"10.1021\/la100818p","article-title":"Novel biocompatible DNA gel particles","volume":"26","author":"Mor\u00e1n","year":"2010","journal-title":"Langmuir"},{"key":"10.1016\/j.ejpb.2012.09.007_b0040","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.ijpharm.2003.10.031","article-title":"Stability and transdermal absorption of topical amphotericin B liposome formulations","volume":"270","author":"Manosroi","year":"2004","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2012.09.007_b0045","doi-asserted-by":"crossref","first-page":"405","DOI":"10.3109\/10611869908996847","article-title":"Enhancement of topical delivery of a lipophilic drug from charged multilamellar liposomes","volume":"6","author":"Katahira","year":"1999","journal-title":"J. Drug Target."},{"key":"10.1016\/j.ejpb.2012.09.007_b0050","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.ijpharm.2009.10.006","article-title":"Surface charged temoporfin-loaded flexible vesicles: in vitro skin penetration studies and stability","volume":"384","author":"Dragicevic-Curic","year":"2010","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2012.09.007_b0055","doi-asserted-by":"crossref","first-page":"49","DOI":"10.3109\/10611860108995632","article-title":"Effect of positively and negatively charged liposomes on skin permeation of drugs","volume":"9","author":"Ogiso","year":"2001","journal-title":"J. Drug Target."},{"key":"10.1016\/j.ejpb.2012.09.007_b0060","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.ijpharm.2011.03.049","article-title":"Liposome surface charge influence on skin penetration behaviour","volume":"411","author":"Gillet","year":"2011","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2012.09.007_b0065","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.chemphyslip.2009.01.006","article-title":"Effect of chain length on physicochemical properties and cytotoxicity of cationic vesicles composed of phosphatidylcholines and dialkyldimethylammonium bromides","volume":"158","author":"Liang","year":"2009","journal-title":"Chem. Phys. Lip."},{"key":"10.1016\/j.ejpb.2012.09.007_b0070","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.colsurfb.2004.12.008","article-title":"Cytotoxicity characterization of catanionic vesicles in RAW 264.7 murine macrophage-like cells","volume":"41","author":"Kuo","year":"2005","journal-title":"Coll. Surf. B Bioint."},{"key":"10.1016\/j.ejpb.2012.09.007_b0075","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1007\/s00216-009-3103-3","article-title":"Nanomaterial characterization: considerations and needs for hazard assessment and safety evaluation","volume":"396","author":"Boverhof","year":"2010","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.ejpb.2012.09.007_b0080","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.tox.2009.11.002","article-title":"Eco-, geno-, and human toxicology of bio-active nanoparticles for biomedical applications","volume":"269","author":"Robbens","year":"2010","journal-title":"Toxicology"},{"key":"10.1016\/j.ejpb.2012.09.007_b0085","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1002\/wnan.54","article-title":"Assessing nanotoxicity in cells in vitro","volume":"2","author":"Hillegass","year":"2009","journal-title":"WIREs Nanomed. Nanobiotechnol."},{"key":"10.1016\/j.ejpb.2012.09.007_b0090","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.yrtph.2012.01.003","article-title":"Genotoxicity evaluation of fullerene C60 nanoparticles in a comet assay using lung cells of intratracheally instilled rats","volume":"62","author":"Ema","year":"2012","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.ejpb.2012.09.007_b0095","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.taap.2008.09.030","article-title":"Limitations and relative utility of screening assays to assess engineered nanoparticle toxicity in a human cell line","volume":"234","author":"Monteiro-Riviere","year":"2009","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.ejpb.2012.09.007_b0100","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1002\/jat.1494","article-title":"Interactions of aluminum nanoparticles with human epidermal keratinocytes","volume":"30","author":"Monteiro-Riviere","year":"2010","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.ejpb.2012.09.007_b0105","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid colorimetric assay to cellular growth and survival: application to proliferation and cytotoxicity assays","volume":"65","author":"Mosmann","year":"1983","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.ejpb.2012.09.007_b0110","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/0378-4274(85)90046-3","article-title":"Toxicity determined in vitro by morphological alterations and neutral red absorption","volume":"24","author":"Borenfreund","year":"1985","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.ejpb.2012.09.007_b0115","unstructured":"OECD, Organisation for Economic Co-operation and Development. Guideline for Testing of Chemicals: In Vitro 3T3 NRU Phototoxicity Test, vol. 432, 2004."},{"key":"10.1016\/j.ejpb.2012.09.007_b0120","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.ejpb.2012.09.007_b0125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.colsurfb.2009.03.018","article-title":"The influence of size, lipid composition and bilayer fluidity of cationic liposomes on the transfection efficiency of nanolipoplexes","volume":"72","author":"Ramezani","year":"2009","journal-title":"Coll. Surf. B: Biointerf."},{"key":"10.1016\/j.ejpb.2012.09.007_b0130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1088\/0957-4484\/22\/49\/494012","article-title":"Facile preparation of a cationic poly(amino acid) vesicle for potential drug and gene co-delivery","volume":"22","author":"Ding","year":"2011","journal-title":"Nanotechnology"},{"key":"10.1016\/j.ejpb.2012.09.007_b0135","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.addr.2003.10.028","article-title":"Lipid vesicles and other colloids as drug carriers on the skin","volume":"56","author":"Cevc","year":"2004","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.ejpb.2012.09.007_b0140","doi-asserted-by":"crossref","first-page":"5900","DOI":"10.1021\/la203974f","article-title":"PH sensitive surfactants from lysine: assessment of their cytotoxicity and environmental behavior","volume":"28","author":"Colomer","year":"2012","journal-title":"Langmuir"},{"key":"10.1016\/j.ejpb.2012.09.007_b0145","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1007\/s00726-011-1176-8","article-title":"Membrane-destabilizing activity of pH-responsive cationic lysine-based surfactants: role of charge position and alkyl chain length","volume":"43","author":"Nogueira","year":"2012","journal-title":"Amino Acids"},{"key":"10.1016\/j.ejpb.2012.09.007_b0150","doi-asserted-by":"crossref","first-page":"11687","DOI":"10.1021\/la300626y","article-title":"Phospholipd bilayer\u2013perturbing properties underlying lysis induced by pH-sensitive lysine-based surfactants in biomembranes","volume":"28","author":"Nogueira","year":"2012","journal-title":"Langmuir"},{"key":"10.1016\/j.ejpb.2012.09.007_b0155","first-page":"139","article-title":"Enhanced depigmenting effects of N-glycosylation inhibitors delivered by pH-sensitive liposomes into HM3KO melanoma cells","volume":"59","author":"Park","year":"2008","journal-title":"J. Cosmet. Sci."},{"key":"10.1016\/j.ejpb.2012.09.007_b0160","doi-asserted-by":"crossref","first-page":"3794","DOI":"10.1016\/j.biomaterials.2011.01.027","article-title":"The potential of celecoxib-loaded hydroxyapatite-chitosan nanocomposite for the treatment of colon cancer","volume":"32","author":"Venkatesan","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.ejpb.2012.09.007_b0165","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1021\/tx200470e","article-title":"In vitro evaluation of cellular response induced by manufactured nanoparticles","volume":"25","author":"Horie","year":"2012","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.ejpb.2012.09.007_b0170","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.colsurfb.2010.08.004","article-title":"Novel pH-sensitive non-ionic surfactant vesicles: comparison between Tween 21 and Tween 20","volume":"82","author":"Di Marzio","year":"2011","journal-title":"Coll. Surf. B Biointerf."},{"key":"10.1016\/j.ejpb.2012.09.007_b0175","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.jcis.2009.06.022","article-title":"Cationic-anionic vesicle templating from fluorocarbon\/fluorocarbon and hydrocarbon\/fluorocarbon surfactants","volume":"338","author":"Ojogun","year":"2009","journal-title":"J. Coll. Interf. Sci."},{"key":"10.1016\/j.ejpb.2012.09.007_b0180","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1248\/cpb.59.315","article-title":"Lomustine loaded chitosan nanoparticles: characterization and in-vitro cytotoxicity on human luna cancer cell line L132","volume":"59","author":"Mehrotra","year":"2011","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.ejpb.2012.09.007_b0185","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1007\/s11051-009-9740-9","article-title":"Toxicity of zinc oxide nanoparticles to zebrafish embryo: a physicochemical study of toxicity mechanism","volume":"12","author":"Bai","year":"2009","journal-title":"J. Nanopart. Res."},{"key":"10.1016\/j.ejpb.2012.09.007_b0190","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0168-3659(97)00205-8","article-title":"Subsolubilizing alterations caused by alkyl glucosides in phosphatidylcholine liposomes","volume":"52","author":"Maza","year":"1998","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ejpb.2012.09.007_b0195","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1023\/B:PHAM.0000041459.63362.6f","article-title":"Assessment of the potential skin irritation of lysine-derivative anionic surfactants using mouse fibroblastsand human keratinocytes as an alternative to animal testing","volume":"21","author":"Sanchez","year":"2004","journal-title":"Pharm. Res."},{"key":"10.1016\/j.ejpb.2012.09.007_b0200","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.tiv.2005.10.014","article-title":"Development of an in vitro skin sensitization test using human cell lines; human cell line activation test (h-CLAT) II. An inter-laboratory study of the h-CLAT","volume":"20","author":"Sakaguchi","year":"2006","journal-title":"Toxicol. in Vitro"},{"key":"10.1016\/j.ejpb.2012.09.007_b0205","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.ijpharm.2011.08.020","article-title":"Comparative sensitivity of tumor and non-tumor cell lines as a reliable approach for in vitro cytotoxicity screening of lysine-based surfactants with potential pharmaceutical applications","volume":"420","author":"Nogueira","year":"2011","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2012.09.007_b0210","first-page":"85","article-title":"Cationic polystyrene nanosphere toxicity depends on cell-specific endocytic and mitochondrial injury pathways","volume":"2","author":"Xia","year":"2008","journal-title":"ACSNano"},{"key":"10.1016\/j.ejpb.2012.09.007_b0215","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1039\/b818082b","article-title":"Analytical methods to assess nanoparticle toxicity","volume":"134","author":"Marquis","year":"2009","journal-title":"Analyst"},{"key":"10.1016\/j.ejpb.2012.09.007_b0220","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0378-5173(01)00660-3","article-title":"Surfactant, but not the size of solid lipid nanoparticles (SLN) influences viability and cytokine production of macrophages","volume":"221","author":"Sch\u00f6ler","year":"2001","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2012.09.007_b0225","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.tox.2004.04.003","article-title":"Assessment of the potential irritation and photoirritation of novel amino acid-based surfactants by in vitro methods as alternative to the animal tests","volume":"201","author":"Benavides","year":"2004","journal-title":"Toxicology"},{"key":"10.1016\/j.ejpb.2012.09.007_b0230","first-page":"247","article-title":"The use of human keratinocytes in the EU\/COLIPA international in vitro phototoxicity test validation study and the ECVAM\/COLIPA study on UV filterchemicals","volume":"27","author":"Clothier","year":"1999","journal-title":"ATLA"},{"key":"10.1016\/j.ejpb.2012.09.007_b0235","doi-asserted-by":"crossref","first-page":"3837","DOI":"10.1016\/j.fct.2008.10.007","article-title":"Comparative evaluation of cytotoxicity and phototoxicity of mono and diacylglycerol amino acid-based surfactants","volume":"46","author":"Vinardell","year":"2008","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.ejpb.2012.09.007_b0240","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1006\/enrs.2002.4335","article-title":"Interleukin-8 secretion from monocytic cell lines for evaluation of the inflammatory potential of organic dust","volume":"88","author":"Allermann","year":"2002","journal-title":"Environm. Res."},{"key":"10.1016\/j.ejpb.2012.09.007_b0245","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.tiv.2007.10.005","article-title":"Role of p38 MAPK in the selective release of IL-8 induced by chemical allergen in na\u00efve THP-1 cells","volume":"22","author":"Mitjans","year":"2008","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.ejpb.2012.09.007_b0250","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.jconrel.2009.08.021","article-title":"In vitro and in vivo performance of biocompatible negatively-charged salbutamol-loaded nanoparticles","volume":"141","author":"Rytting","year":"2010","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ejpb.2012.09.007_b0255","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/0140-6736(91)92168-2","article-title":"Keratinocytes as initiators of inflammation","volume":"337","author":"Barker","year":"1991","journal-title":"Lancet"},{"key":"10.1016\/j.ejpb.2012.09.007_b0260","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.toxlet.2006.01.005","article-title":"Evaluation of eye and skin irritation of arginine-derivative surfactants using different in vitro endpoints as alternatives to the in vivo assays","volume":"164","author":"Mart\u00ednez","year":"2006","journal-title":"Toxicol. Lett."}],"container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641112002913?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641112002913?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T16:30:08Z","timestamp":1760545808000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0939641112002913"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1]]},"references-count":52,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["S0939641112002913"],"URL":"https:\/\/doi.org\/10.1016\/j.ejpb.2012.09.007","relation":{},"ISSN":["0939-6411"],"issn-type":[{"value":"0939-6411","type":"print"}],"subject":[],"published":{"date-parts":[[2013,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"New cationic nanovesicular systems containing lysine-based surfactants for topical administration: Toxicity assessment using representative skin cell lines","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutics and Biopharmaceutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejpb.2012.09.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}