{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:21:42Z","timestamp":1788870102883,"version":"build-2803163510"},"reference-count":45,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China 973 program","doi-asserted-by":"crossref","award":["2007CB935802"],"award-info":[{"award-number":["2007CB935802"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["2009ZX09310-006"],"award-info":[{"award-number":["2009ZX09310-006"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Science and Technology Major Project"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"published-print":{"date-parts":[[2013,2]]},"DOI":"10.1016\/j.ejpb.2012.09.014","type":"journal-article","created":{"date-parts":[[2012,10,23]],"date-time":"2012-10-23T04:35:44Z","timestamp":1350966944000},"page":"266-274","source":"Crossref","is-referenced-by-count":72,"title":["Mechanism of inhibition of P-glycoprotein mediated efflux by Pluronic P123\/F127 block copolymers: Relationship between copolymer concentration and inhibitory activity"],"prefix":"10.1016","volume":"83","author":[{"given":"Zhang","family":"Wei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junguo","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoling","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejpb.2012.09.014_b0005","doi-asserted-by":"crossref","first-page":"273","DOI":"10.2174\/138161206775201965","article-title":"An update on overcoming MDR1-mediated multidrug resistance in cancer chemotherapy","volume":"12","author":"Takara","year":"2006","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.ejpb.2012.09.014_b0010","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/nrd1984","article-title":"Targeting multidrug resistance in cancer","volume":"5","author":"Szak\u00e1cs","year":"2006","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.ejpb.2012.09.014_b0015","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.jconrel.2008.04.013","article-title":"Pluronic block copolymers: evolution of drug delivery concept from inert nanocarriers to biological response modifiers","volume":"130","author":"Batrakova","year":"2008","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ejpb.2012.09.014_b0020","doi-asserted-by":"crossref","first-page":"5148","DOI":"10.1016\/j.biomaterials.2011.03.071","article-title":"Role of cellular uptake in the reversal of multidrug resistance by PEG-b-PLA polymeric micelles","volume":"32","author":"Xiao","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.ejpb.2012.09.014_b0025","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.1002\/jps.22461","article-title":"Pegylated phosphotidylethanolamine inhibiting P-glycoprotein expression and enhancing retention of Doxorubicin in MCF7\/ADR cells","volume":"100","author":"Wang","year":"2011","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2012.09.014_b0030","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1021\/mp060121r","article-title":"Mechanism of inhibition of P-glycoprotein mediated efflux by vitamin E TPGS: influence on ATPase activity and membrane fluidity","volume":"4","author":"Collnot","year":"2007","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.ejpb.2012.09.014_b0035","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0169-409X(02)00176-X","article-title":"Pluronic block copolymers as modulators of drug efflux transporter activity in the blood-brain barrier","volume":"55","author":"Kabanov","year":"2003","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"4","key":"10.1016\/j.ejpb.2012.09.014_b0040","first-page":"4080","article-title":"SP1049C as first-line therapy in advanced (inoperable or metastatic) adenocarcinoma of the oesophagus: a phase II window study","volume":"2","author":"Armstrong","year":"2006","journal-title":"ASCO Annu. Meet. Proc. Part I. J. Clin. Oncol."},{"key":"10.1016\/j.ejpb.2012.09.014_b0045","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1038\/sj.bjc.6601856","article-title":"Phase I dose escalation and pharmacokinetic study of pluronic polymer-bound doxorubicin(SP1049C) in patients with advanced cancer","volume":"90","author":"Danson","year":"2004","journal-title":"Brit. J. Cancer"},{"key":"10.1016\/j.ejpb.2012.09.014_b0050","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0378-5173(01)00986-3","article-title":"Paclitaxel and its formulation","volume":"235","author":"Singla","year":"2002","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2012.09.014_b0055","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1021\/mp100012s","article-title":"Paclitaxel nanocrystals for overcoming multidrug resistance in cancer","volume":"7","author":"Liu","year":"2010","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.ejpb.2012.09.014_b0060","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1200\/JCO.1990.8.7.1263","article-title":"Hypersensitivity reactions from Taxol","volume":"8","author":"Weiss","year":"1990","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.ejpb.2012.09.014_b0065","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1016\/j.addr.2007.08.044","article-title":"Protein nanoparticles as drug carrier in clinical medicine","volume":"60","author":"Michael","year":"2008","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.ejpb.2012.09.014_b0070","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0168-3659(01)00299-1","article-title":"Structure and design of polymeric surfactant-based drug delivery systems","volume":"73","author":"Torchilin","year":"2001","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ejpb.2012.09.014_b0075","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.ijpharm.2009.04.030","article-title":"Paclitaxel-loaded Pluronic P123\/F127 mixed polymeric micelles: formulation, optimization and in vitro characterization","volume":"376","author":"Zhang","year":"2009","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2012.09.014_b0080","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.ejpb.2010.04.017","article-title":"Enhanced antitumor efficacy by Paclitaxel-loaded Pluronic P123\/F127 mixed micelles against non-small cell lung cancer based on passive tumor targeting and modulation of drug resistance","volume":"75","author":"Zhang","year":"2010","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ejpb.2012.09.014_b0085","doi-asserted-by":"crossref","first-page":"2894","DOI":"10.1016\/j.biomaterials.2010.12.039","article-title":"Multifunctional Pluronic P123\/F127 mixed polymeric micelles loaded with paclitaxel for the treatment of multidrug resistant tumors","volume":"32","author":"Zhang","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.ejpb.2012.09.014_b0090","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1023\/B:PHAM.0000036925.45002.a2","article-title":"Evidence for modulation of P-glycoprotein-mediated efflux by methoxypolyethylene glycol-block-Polycaprolactone amphiphilic diblock copolymers","volume":"21","author":"Zastre","year":"2004","journal-title":"Pharm. Res."},{"key":"10.1016\/j.ejpb.2012.09.014_b0095","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1023\/A:1011964213024","article-title":"Effects of pluronic block copolymers on drug absorption in Caco-2 cell monolayers","volume":"15","author":"Batrakova","year":"1998","journal-title":"Pharm. Res."},{"key":"10.1016\/j.ejpb.2012.09.014_b0100","doi-asserted-by":"crossref","first-page":"4267","DOI":"10.1016\/0006-2952(89)90525-X","article-title":"Relevance of the chemical charge of rhodamine dyes to multiple drug resistance","volume":"38","author":"Lampidis","year":"1989","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejpb.2012.09.014_b0105","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1021\/mp7001347","article-title":"P-glycoprotein efflux inhibition by amphiphilic diblock copolymers: relationship between copolymer concentration and substrate hydrophobicity","volume":"5","author":"Zastre","year":"2008","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.ejpb.2012.09.014_b0110","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1021\/mp900021q","article-title":"In vivo evaluation of doxorubicin-loaded polymeric micelles targeting folate receptors and early endosomal pH in Drug-resistant ovarian cancer","volume":"6","author":"Kim","year":"2009","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.ejpb.2012.09.014_b0115","doi-asserted-by":"crossref","first-page":"4293","DOI":"10.1016\/j.biomaterials.2011.02.044","article-title":"Angiopep-conjugated poly(ethylene glycol)-co-poly(\u03b5-caprolactone) nanoparticles as dual-targeting drug delivery system for brain glioma","volume":"32","author":"Xin","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.ejpb.2012.09.014_b0120","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1124\/jpet.102.043307","article-title":"Optimal structure requirements for pluronic block copolymers in modifying p-glycoprotein drug efflux transporter activity in bovine brain microvessel endothelial cells","volume":"304","author":"Batrakova","year":"2003","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejpb.2012.09.014_b0125","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1023\/A:1018873702411","article-title":"Inhibition of multidrug resistance-associated protein (MRP) functional activity with Pluronic block copolymers","volume":"19","author":"Miller","year":"1999","journal-title":"Pharm. Res."},{"key":"10.1016\/j.ejpb.2012.09.014_b0130","doi-asserted-by":"crossref","first-page":"4170","DOI":"10.1002\/jps.21723","article-title":"Investigation of the micellar effect of Pluronic P85 on P-glycoprotein inhibition: cell accumulation and equilibrium dialysis studies","volume":"98","author":"Shaik","year":"2009","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2012.09.014_b0135","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.ijpharm.2011.02.025","article-title":"The effect of polymeric additives on the solubilisation of a poorly-soluble drug in micellar solution of Pluronic F127","volume":"409","author":"Oliveira","year":"2011","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2012.09.014_b0140","first-page":"592","article-title":"Ligand docking and scoring in DNA oligonucleotides. Binding of doxorubicin and modeled analogues to optimize sequence specificity","volume":"9","author":"Kellogg","year":"1999","journal-title":"Med. Chem. Res."},{"key":"10.1016\/j.ejpb.2012.09.014_b0145","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/sj.jid.5700485","article-title":"Nanoemulsions as versatile formulations for paclitaxel delivery: peroral and dermal delivery studies in rats","volume":"127","author":"Khandavilli","year":"2007","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.ejpb.2012.09.014_b0150","doi-asserted-by":"crossref","first-page":"32367","DOI":"10.1074\/jbc.M400735200","article-title":"Weak base permeability characteristics influence the intracellular sequestration site in the multidrug-resistant human leukemic cell line HL-60","volume":"279","author":"Duvvuri","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejpb.2012.09.014_b0155","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1002\/jps.21479","article-title":"Reversal of multidrug resistance by methoxypolyethylene glycol-block-polycaprolactone diblock copolymers through the inhibition of P-glycoprotein functions","volume":"98","author":"Elamanchili","year":"2009","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2012.09.014_b0160","doi-asserted-by":"crossref","first-page":"6887","DOI":"10.1021\/bi990064q","article-title":"The membrane lipid environment modulates drug interactions with the P-glycoprotein multidrug transporter","volume":"38","author":"Romsicki","year":"1999","journal-title":"Biochemistry"},{"key":"10.1016\/j.ejpb.2012.09.014_b0165","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1046\/j.1432-1327.1998.2510252.x","article-title":"A general pattern for substrate recognition by P-glycoprotein","volume":"251","author":"Seelig","year":"1998","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.ejpb.2012.09.014_b0170","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1124\/mol.58.3.624","article-title":"Communication between multiple drug binding sites on P-glycoprotein","volume":"58","author":"Martin","year":"2000","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.ejpb.2012.09.014_b0175","first-page":"227","article-title":"The mechanism of ATP-dependent multidrug transport by P-glycoprotein","volume":"643","author":"Shapiro","year":"1998","journal-title":"Acta Physiol. Scand. Suppl."},{"key":"10.1016\/j.ejpb.2012.09.014_b0180","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1126\/science.281.5381.1309","article-title":"Mitochondria and apoptosis","volume":"281","author":"Green","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.ejpb.2012.09.014_b0185","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/scientificamerican1296-80","article-title":"Cell suicide in health and disease","volume":"275","author":"Duke","year":"1996","journal-title":"Sci. Am."},{"key":"10.1016\/j.ejpb.2012.09.014_b0190","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1007\/BF02255913","article-title":"Mitochondrial role in life and death of the cell","volume":"7","author":"Lee","year":"2000","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.ejpb.2012.09.014_b0195","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1128\/JVI.01229-07","article-title":"Inhibition of endosome-lysosome system acidification enhances porcine circovirus 2 infection of porcine epithelial cells","volume":"82","author":"Misinzo","year":"2008","journal-title":"J. Virol."},{"key":"10.1016\/j.ejpb.2012.09.014_b0200","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1007\/s000180050214","article-title":"The effect of monensin and chloroquine on the endocytosis and toxicity of chimeric toxins","volume":"54","author":"Ippoliti","year":"1998","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.ejpb.2012.09.014_b0205","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1021\/bc8002315","article-title":"Different internalization pathways of polymeric micelles and unimers and their effects on vesicular transport","volume":"19","author":"Shay","year":"2008","journal-title":"Bioconjugate Chem."},{"key":"10.1016\/j.ejpb.2012.09.014_b0210","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.ijpharm.2006.12.033","article-title":"Difunctional Pluronic copolymer micelles for paclitaxel delivery: synergistic effect of folate-mediated targeting and Pluronic-mediated overcoming multidrug resistance in tumor cell lines","volume":"337","author":"Wang","year":"2007","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2012.09.014_b0215","doi-asserted-by":"crossref","first-page":"5398","DOI":"10.1002\/adma.201003162","article-title":"Bypassing multidrug resistance in cancer cells with biodegradable polymer capsules","volume":"22","author":"Yan","year":"2010","journal-title":"Adv. Mater."},{"key":"10.1016\/j.ejpb.2012.09.014_b0220","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0168-3659(03)00218-9","article-title":"Drug delivery in polymeric micelles: from in vitro to in vivo","volume":"91","author":"Rapoport","year":"2003","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ejpb.2012.09.014_b0225","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/S0014-5793(99)00208-2","article-title":"Interaction of tumor and normal blood cells with ethylene oxide and propylene oxide block copolymers","volume":"446","author":"Melik-Nubarov","year":"1999","journal-title":"FEBS Lett."}],"container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641112003128?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641112003128?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,7]],"date-time":"2020-05-07T02:02:09Z","timestamp":1588816929000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0939641112003128"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2]]},"references-count":45,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["S0939641112003128"],"URL":"https:\/\/doi.org\/10.1016\/j.ejpb.2012.09.014","relation":{},"ISSN":["0939-6411"],"issn-type":[{"value":"0939-6411","type":"print"}],"subject":[],"published":{"date-parts":[[2013,2]]}}}