{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T10:40:59Z","timestamp":1791196859419,"version":"4.1.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,11,1]],"date-time":"2015-11-01T00:00:00Z","timestamp":1446336000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"published-print":{"date-parts":[[2015,11]]},"DOI":"10.1016\/j.ejpb.2015.01.021","type":"journal-article","created":{"date-parts":[[2015,2,3]],"date-time":"2015-02-03T12:41:17Z","timestamp":1422967277000},"page":"239-249","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":48,"special_numbering":"PA","title":["On the synthesis of mucus permeating nanocarriers"],"prefix":"10.1016","volume":"97","author":[{"given":"Vassilis","family":"Bourganis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodora","family":"Karamanidou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleni","family":"Samaridou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantina","family":"Karidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Kammona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Costas","family":"Kiparissides","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejpb.2015.01.021_b0010","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.addr.2008.11.002","article-title":"Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues","volume":"61","author":"Lai","year":"2009","journal-title":"Adv. Drug Delivery Rev."},{"issue":"2","key":"10.1016\/j.ejpb.2015.01.021_b0015","doi-asserted-by":"crossref","first-page":"762","DOI":"10.3390\/polym3020762","article-title":"Polyelectrolyte complex nanoparticles of poly(ethyleneimine) and poly(acrylic acid): preparation and applications","volume":"3","author":"M\u00fcller","year":"2011","journal-title":"Polymers"},{"issue":"1","key":"10.1016\/j.ejpb.2015.01.021_b0020","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.ejpb.2010.12.001","article-title":"Colloidal polyelectrolyte complexes of chitosan and dextran sulfate towards versatile nanocarriers of bioactive molecules","volume":"78","author":"Delair","year":"2011","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ejpb.2015.01.021_b0025","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/b11350","article-title":"Polyelectrolyte complexes","volume":"166","author":"Th\u00fcnemann","year":"2004","journal-title":"Adv. Polym. Sci."},{"key":"10.1016\/j.ejpb.2015.01.021_b0030","doi-asserted-by":"crossref","first-page":"9726","DOI":"10.1002\/anie.200803526","article-title":"Addressing the PEG mucoadhesivity paradox to engineer nanoparticles that \u201cslip\u201d through the human mucus barrier","volume":"47","author":"Wang","year":"2008","journal-title":"Angew. Chem. Int. Ed."},{"issue":"1","key":"10.1016\/j.ejpb.2015.01.021_b0035","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1021\/mp8001254","article-title":"Controlled surface modification with poly(ethylene)glycol enhances diffusion of PLGA nanoparticles in human cervical mucus","volume":"6","author":"Cu","year":"2009","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.ejpb.2015.01.021_b0040","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1007\/s13346-011-0048-9","article-title":"Biodegradable mucus-penetrating nanoparticles composed of diblock copolymers of polyethylene glycol and poly(lactic-co-glycolic acid)","volume":"2","author":"Yu","year":"2012","journal-title":"Drug Delivery Transl. Res."},{"key":"10.1016\/j.ejpb.2015.01.021_b0045","article-title":"Development and in vitro evaluation of slippery nanoparticles for enhanced diffusion through native mucus","author":"Laffleur","year":"2013","journal-title":"Nanomedicine"},{"issue":"1","key":"10.1016\/j.ejpb.2015.01.021_b0050","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.prrv.2007.02.009","article-title":"Mucolytics in cystic fibrosis","volume":"8","author":"Henke","year":"2007","journal-title":"Paediatr. Respir. Rev."},{"issue":"2","key":"10.1016\/j.ejpb.2015.01.021_b0055","doi-asserted-by":"crossref","first-page":"365","DOI":"10.2217\/nnm.10.123","article-title":"Rapid transport of muco-inert nanoparticles in cystic fibrosis sputum treated with N-acetyl cysteine","volume":"6","author":"Suk","year":"2011","journal-title":"Nanomedicine (Lond.)"},{"issue":"11","key":"10.1016\/j.ejpb.2015.01.021_b0060","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1038\/mt.2011.160","article-title":"N-acetylcysteine enhances cystic fibrosis sputum penetration and airway gene transfer by highly compacted DNA nanoparticles","volume":"19","author":"Suk","year":"2011","journal-title":"Mol. Ther."},{"key":"10.1016\/j.ejpb.2015.01.021_b0065","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1021\/jm1013715","article-title":"Targeted biocompatible nanoparticles for the delivery of (\u2212)-epigallocatechin 3-gallate to prostate cancer cells","volume":"54","author":"Sanna","year":"2011","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejpb.2015.01.021_b0070","unstructured":"T. Betancourt, Targetable Biodegradable Nanoparticles for Delivery of Chemotherapeutic and Imaging Agents to Ovarian Cancer, PhD Dissertation, The University of Texas at Austin, 2007."},{"key":"10.1016\/j.ejpb.2015.01.021_b0075","first-page":"4749","article-title":"Polymeric nanoparticles conjugate a novel heptapeptide as an epidermal growth factor receptor-active targeting ligand for doxorubicin","volume":"7","author":"Liu","year":"2012","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.ejpb.2015.01.021_b0080","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1016\/j.jpba.2007.03.010","article-title":"Pharmaceutical analysis of synthetic lipid A-based vaccine adjuvants in poly(d,l-lactic-co-glycolic acid) nanoparticle formulations","volume":"44","author":"Hamdy","year":"2007","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.ejpb.2015.01.021_b0085","doi-asserted-by":"crossref","first-page":"5304","DOI":"10.1021\/nl302638g","article-title":"PEGylated PRINT nanoparticles: the impact of PEG density on protein binding, macrophage association, biodistribution, and pharmacokinetics","volume":"12","author":"Perry","year":"2012","journal-title":"Nano Lett."},{"key":"10.1016\/j.ejpb.2015.01.021_b0090","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S0927-7765(99)00156-3","article-title":"\u201cStealth\u201d corona-core nanoparticles surface modified by polyethylene glycol (Peg): influences of the corona (PEG chain length and surface density) and of the core composition on phagocytic uptake and plasma protein adsorption","volume":"18","author":"Gref","year":"2000","journal-title":"Colloid Surf. B"},{"key":"10.1016\/j.ejpb.2015.01.021_b0095","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1021\/la0483257","article-title":"Needlelike and spherical polyelectrolyte complex nanoparticles of poly(L-lysine) and copolymers of maleic acid","volume":"21","author":"M\u00fcller","year":"2005","journal-title":"Langmuir"},{"key":"10.1016\/j.ejpb.2015.01.021_b0100","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.jcis.2010.07.015","article-title":"Degradability of poly(L-lysine) and poly(DL-aminoserinate) complexed with a polyanion under conditions modelling physico-chemical characteristics of body fluids","volume":"350","author":"Leclercq","year":"2010","journal-title":"J. Colloid Interf. Sci."},{"key":"10.1016\/j.ejpb.2015.01.021_b0105","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.jconrel.2010.08.026","article-title":"Peritoneal retention of liposomes: effects of lipid composition, PEG coating and liposome charge","volume":"148","author":"Dadashzadeh","year":"2010","journal-title":"J. Control. Release"},{"issue":"3","key":"10.1016\/j.ejpb.2015.01.021_b0110","doi-asserted-by":"crossref","first-page":"309","DOI":"10.3109\/02652049409040460","article-title":"Liposomes as carriers of different new lipophilic antitumour drugs: a preliminary report","volume":"11","author":"Sampedro","year":"1994","journal-title":"J. Microencapsul."},{"key":"10.1016\/j.ejpb.2015.01.021_b0115","doi-asserted-by":"crossref","first-page":"5524","DOI":"10.1039\/B206351D","article-title":"Association of amyloid-b peptide with membrane surfaces monitored by solid state NMR","volume":"4","author":"Lindstr\u00f6m","year":"2002","journal-title":"Phys. Chem. Chem. Phys."},{"key":"10.1016\/j.ejpb.2015.01.021_b0120","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1006\/jcis.2002.8567","article-title":"Complementary liposomes based on phosphatidylcholine: interaction effectiveness vs protective coating","volume":"253","author":"Pantos","year":"2002","journal-title":"J. Colloid Interf. Sci."},{"key":"10.1016\/j.ejpb.2015.01.021_b0125","doi-asserted-by":"crossref","first-page":"4052","DOI":"10.1016\/j.biomaterials.2011.02.011","article-title":"In vivo evidence of oral vaccination with PLGA nanoparticles containing the immunostimulant monophosphoryl lipid A","volume":"32","author":"Sarti","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.ejpb.2015.01.021_b0130","first-page":"101","article-title":"Preparation, characterization, and in vitro release study of albendazole-encapsulated nanosize liposomes","volume":"5","author":"Panwar","year":"2010","journal-title":"Int. J. Nanomedicine"},{"issue":"2","key":"10.1016\/j.ejpb.2015.01.021_b0135","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.ajps.2013.07.013","article-title":"Preparation of bromfenac-loaded liposomes modified with chitosan for ophthalmic drug delivery and evaluation of physicochemical properties and drug release profile","volume":"8","author":"Tsukamoto","year":"2013","journal-title":"Asian J. Pharm. Sci."},{"issue":"12","key":"10.1016\/j.ejpb.2015.01.021_b0140","doi-asserted-by":"crossref","first-page":"4406","DOI":"10.1002\/jps.23757","article-title":"Development and evaluation of a novel mucus diffusion test system approved by self-nanoemulsifying drug delivery systems","volume":"102","author":"Friedl","year":"2013","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2015.01.021_b0145","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.jconrel.2005.10.010","article-title":"Encapsulation of the immune potentiators MPL and RC529 in PLG microparticles enhances their potency","volume":"110","author":"Kazzaz","year":"2006","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ejpb.2015.01.021_b0150","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0168-3659(01)00218-8","article-title":"PEGylated PLGA nanoparticles as protein carriers: synthesis, preparation and biodistribution in rats","volume":"71","author":"Li","year":"2001","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ejpb.2015.01.021_b0155","doi-asserted-by":"crossref","first-page":"3887","DOI":"10.1002\/adma.201201800","article-title":"Mucus penetrating nanoparticles: biophysical tool and method of drug and gene delivery","volume":"24","author":"Ensign","year":"2012","journal-title":"Adv. Mater."},{"key":"10.1016\/j.ejpb.2015.01.021_b0160","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.ijpharm.2005.10.010","article-title":"Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles","volume":"307","author":"Owens","year":"2006","journal-title":"Int. J. Pharm."},{"issue":"1","key":"10.1016\/j.ejpb.2015.01.021_b0165","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1021\/bm0604754","article-title":"Development of improved nanoparticulate polyelectrolyte complex physicochemistry by nonstoichiometric mixing of polyions with similar molecular weights","volume":"8","author":"Hartig","year":"2007","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.ejpb.2015.01.021_b0170","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.ejpb.2011.04.008","article-title":"A new drug nanocarrier consisting of polyarginine and hyaluronic acid","volume":"79","author":"Oyarzun-Ampuero","year":"2011","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ejpb.2015.01.021_b0175","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/0378-5173(90)90041-2","article-title":"Characteristics of polyion complexes of chitosan with sodium alginate and sodium polyacrylate","volume":"61","author":"Takahashi","year":"1990","journal-title":"Int. J. Pharm."},{"issue":"4","key":"10.1016\/j.ejpb.2015.01.021_b0180","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1208\/pt0804098","article-title":"Designing chitosan-dextran sulfate nanoparticles using charge ratios","volume":"8","author":"Chen","year":"2007","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.ejpb.2015.01.021_b0185","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jconrel.2007.01.016","article-title":"Estradiol loaded PLGA nanoparticles for oral administration: effect of polymer molecular weight and copolymer composition on release behavior in vitro and in vivo","volume":"119","author":"Mittal","year":"2007","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ejpb.2015.01.021_b0190","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1007\/s00396-003-1015-x","article-title":"Effect of a PEG lipid (DSPEPEG2000) and freeze-thawing process on phospholipid vesicle size and lamellarity","author":"Sriwongsitanont","year":"2004","journal-title":"Colloid Polym. Sci."},{"key":"10.1016\/j.ejpb.2015.01.021_b0195","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.ejpb.2004.03.028","article-title":"Physicochemical characterisation of colloidal drug delivery systems such as reverse micelles, vesicles, liquid crystals and nanoparticles for topical administration","volume":"58","author":"Muller-Goymann","year":"2004","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ejpb.2015.01.021_b0200","doi-asserted-by":"crossref","unstructured":"R.A. Schwendener, H. Schott, Liposome formulations of hydrophobic drugs, in: V. Weissig (Ed.), Liposomes Methods and Protocols, vol. 1: Pharmaceutical Nanocarriers, Series: Liposomes Methods in Molecular Biology, vol. 605, Humana Press, 2010, pp. 129\u2013138.","DOI":"10.1007\/978-1-60327-360-2_8"},{"key":"10.1016\/j.ejpb.2015.01.021_b0205","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.ejpb.2013.10.006","article-title":"2-Dioleoyl-sn-glycero-3-phosphocholine-based nanoliposomes5 as an effective delivery platform for 17b-estradiol","volume":"86","author":"Bowey","year":"2014","journal-title":"Eur. J. Pharm. Biopharm."},{"issue":"1","key":"10.1016\/j.ejpb.2015.01.021_b0210","first-page":"111","article-title":"Factors affecting drug release from liposomes","volume":"13","author":"Lindner","year":"2010","journal-title":"Curr. Opin. Drug Discov. Dev."},{"key":"10.1016\/j.ejpb.2015.01.021_b0215","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1080\/10717540490265243","article-title":"The effect of different lipid components on the in vitro stability and release kinetics of liposome formulations","volume":"11","author":"Anderson","year":"2004","journal-title":"Drug Delivery"},{"issue":"1\u20133","key":"10.1016\/j.ejpb.2015.01.021_b0220","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/0009-3084(93)90053-6","article-title":"Chemical stability of liposomes: implications for their physical stability","volume":"64","author":"Grit","year":"1993","journal-title":"Chem. Phys. Lipids"},{"key":"10.1016\/j.ejpb.2015.01.021_b0225","first-page":"311","article-title":"In vitro release of hydrophilic and hydrophobic drugs from liposomal dispersions and gels","volume":"56","author":"Nounou","year":"2006","journal-title":"Acta Pharm."},{"key":"10.1016\/j.ejpb.2015.01.021_b0230","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.jconrel.2013.05.035","article-title":"Scalable method to produce biodegradable nanoparticles that rapidly penetrate human mucus","volume":"170","author":"Xu","year":"2013","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ejpb.2015.01.021_b0235","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1016\/0016-5085(86)90198-8","article-title":"Charge selectivity of rat intestinal capillaries. Influence of polycations","volume":"91","author":"Granger","year":"1986","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ejpb.2015.01.021_b0240","unstructured":"J. Hanes, K. Wai Y. Chan, M.T. Mcmahon, M. Yang, T. Yu, Lipid-based Drug Carriers for Rapid Penetration through Mucus Linings, WO2013166498, Patent."}],"container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641115000375?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641115000375?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,25]],"date-time":"2018-09-25T09:56:37Z","timestamp":1537869397000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0939641115000375"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11]]},"references-count":47,"alternative-id":["S0939641115000375"],"URL":"https:\/\/doi.org\/10.1016\/j.ejpb.2015.01.021","relation":{},"ISSN":["0939-6411"],"issn-type":[{"value":"0939-6411","type":"print"}],"subject":[],"published":{"date-parts":[[2015,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"On the synthesis of mucus permeating nanocarriers","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutics and Biopharmaceutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejpb.2015.01.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}